Protein Alignment BRD3 and tbrd-2

DIOPT Version :10

• Sequence 1: NP_031397.1
• Gene: BRD3 / 8019
• HGNCID: 1104
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_611401.2
• Gene: tbrd-2 / 37207
• FlyBaseID: FBgn0034423
• Length: 674
• Species: Drosophila melanogaster
• Alignment Length: 801
• Identity: 156/801 - (19%)
• Similarity: 278/801 - (34%)
• Gaps: 244/801 - (30%)

Human    18 PVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMD 82
            |....|..:.:|...||.||:|.|.:..::....|.::|..|.:|||...|.:|.|:.:|..|||
  Fly    14 PNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMD 78

Human    83 MGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVEL 147
            :|||.||::||||.|.:|.:.||..:.:||:::|:..|.:....|.|||.|.:|:..||......
  Fly    79 IGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSGPEVP 143

Human   148 LPPAPKGKGRKPAAGAQSAGT-------------------------------------------- 168
            ....||..||.......||.|
  Fly   144 CNRDPKAVGRPRTNAPSSAQTERKCRELLKKLQSITNQTDAMTRNFFSNKWDSLQKKVDRQYFKS 208

Human   169 ----------------------------QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTIT 205
                                        |..|..:|::..:..:|.........::||..: |:.
  Fly   209 VNEFCLHVDGCFRKYHEPAKILYERVFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKL-TVN 272

Human   206 ANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDP 270
            :.:..|.:|.:.                .|:..|..|:...||.....:.:.|.:..||.| |..
  Fly   273 SLMQCVQMPGSG----------------EPLTAKSLVETFCDTLNKMINKMEAGQRNSPNP-SSS 320

Human   271 KQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFY 335
            |:.|:...:|:          ||..||                                     :
  Fly   321 KRQKMSPEQET----------DLVQGE-------------------------------------F 338

Human   336 KPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAM 400
            ||    |:||                   :.|.|..:....:.:            ..|.|.:..
  Fly   339 KP----AMEL-------------------LSGNEIDNLMAVSIE------------SSDDEAIDA 368

Human   401 ARKLQD----VFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERAT 461
            :.::.|    ..:..|||:|...::         .::....:....|.|:..|
  Fly   369 SMRITDADRCATQKLFAKLPTNAMK---------EIIHMVQQIEGFSSENCGD------------ 412

Human   462 RLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPP 526
                |...:|.:......:.::.|.|..:...|    .|.||.:..:::...:|.:.:...:...
  Fly   413 ----LSFDVKGLATDTMIMMKSAVTKATRAHSK----LKLKDMQPSEKEGLQRALQSQLVNITRM 469

Human   527 AKQAQQKKAP-AKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGE 590
            ..:.:::..| ....|...||...::   |:|:|           |::...|   .|..| :...
  Fly   470 LNKNRRRCGPLINFRNKNNTANNVVR---KRATA-----------PLTAKLK---PLQAN-VMAP 516

Human   591 KLGRVVHIIQSREPSLRDSNPDEIE--IDFETLKPTTLRELERYVKSCLQKKQRKP--------- 644
            :||  ..::::.  :|.|::.|::.  :....:..|.:|.|.........:..|.|
  Fly   517 QLG--AGVVETH--NLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVVEL 577

Human   645 --FSASGKKQAAKSKE-ELAQEKKKEL-EKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSS 705
              .|:|..:...|||. .|::.:.:.: :.:|:..|...:||:..:......:|.|...|| |.|
  Fly   578 QMSSSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSR-SRS 641

Human   706 SSSESGSSSSSGSSSDSSDSE 726
            |||.|.||::|..|:||||.|
  Fly   642 SSSSSSSSNNSSESNDSSDVE 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BRD3	NP_031397.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		4/16 (25%)
		Bromo_Brdt_I_like	34..140	CDD:99929	41/105 (39%)
		Acetylated histone H3 binding. /evidence=ECO:0000269|PubMed:27105114	78..80		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..169		7/91 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..305		16/67 (24%)
		Bromo_Brdt_II_like	311..412	CDD:99930	10/104 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..462		3/40 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..575		15/98 (15%)
		BET	571..635	CDD:435704	12/65 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..726		30/101 (30%)
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	38/101 (38%)