DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRD3 and tbrd-2

DIOPT Version :9

Sequence 1:	NP_031397.1	Gene:	BRD3 / 8019	HGNCID:	1104	Length:	726	Species:	Homo sapiens
Sequence 2:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	801	Identity:	156/801 - (19%)
Similarity:	278/801 - (34%)	Gaps:	244/801 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    18 PVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMD 82
            |....|..:.:|...||.||:|.|.:..::....|.::|..|.:|||...|.:|.|:.:|..|||
  Fly    14 PNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMD 78

Human    83 MGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVEL 147
            :|||.||::||||.|.:|.:.||..:.:||:::|:..|.:....|.|||.|.:|:..||......
  Fly    79 IGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSGPEVP 143

Human   148 LPPAPKGKGRKPAAGAQSAGT-------------------------------------------- 168
            ....||..||.......||.|
  Fly   144 CNRDPKAVGRPRTNAPSSAQTERKCRELLKKLQSITNQTDAMTRNFFSNKWDSLQKKVDRQYFKS 208

Human   169 ----------------------------QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTIT 205
                                        |..|..:|::..:..:|.........::||..: |:.
  Fly   209 VNEFCLHVDGCFRKYHEPAKILYERVFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKL-TVN 272

Human   206 ANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDP 270
            :.:..|.:|.:.                .|:..|..|:...||.....:.:.|.:..||.| |..
  Fly   273 SLMQCVQMPGSG----------------EPLTAKSLVETFCDTLNKMINKMEAGQRNSPNP-SSS 320

Human   271 KQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFY 335
            |:.|:...:|:          ||..||                                     :
  Fly   321 KRQKMSPEQET----------DLVQGE-------------------------------------F 338

Human   336 KPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAM 400
            ||    |:||                   :.|.|..:....:.:            ..|.|.:..
  Fly   339 KP----AMEL-------------------LSGNEIDNLMAVSIE------------SSDDEAIDA 368

Human   401 ARKLQD----VFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERAT 461
            :.::.|    ..:..|||:|...::         .::....:....|.|:..|
  Fly   369 SMRITDADRCATQKLFAKLPTNAMK---------EIIHMVQQIEGFSSENCGD------------ 412

Human   462 RLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPP 526
                |...:|.:......:.::.|.|..:...|    .|.||.:..:::...:|.:.:...:...
  Fly   413 ----LSFDVKGLATDTMIMMKSAVTKATRAHSK----LKLKDMQPSEKEGLQRALQSQLVNITRM 469

Human   527 AKQAQQKKAP-AKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGE 590
            ..:.:::..| ....|...||...::   |:|:|           |::...|   .|..| :...
  Fly   470 LNKNRRRCGPLINFRNKNNTANNVVR---KRATA-----------PLTAKLK---PLQAN-VMAP 516

Human   591 KLGRVVHIIQSREPSLRDSNPDEIE--IDFETLKPTTLRELERYVKSCLQKKQRKP--------- 644
            :||  ..::::.  :|.|::.|::.  :....:..|.:|.|.........:..|.|
  Fly   517 QLG--AGVVETH--NLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVVEL 577

Human   645 --FSASGKKQAAKSKE-ELAQEKKKEL-EKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSS 705
              .|:|..:...|||. .|::.:.:.: :.:|:..|...:||:..:......:|.|...|| |.|
  Fly   578 QMSSSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSR-SRS 641

Human   706 SSSESGSSSSSGSSSDSSDSE 726
            |||.|.||::|..|:||||.|
  Fly   642 SSSSSSSSNNSSESNDSSDVE 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRD3	NP_031397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		4/16 (25%)
		Bromo_Brdt_I_like	34..140	CDD:99929	41/105 (39%)
		Acetylated histone H3 binding. /evidence=ECO:0000269\|PubMed:27105114	78..80		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..169		7/91 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..305		16/67 (24%)
		Bromo_Brdt_II_like	311..412	CDD:99930	10/104 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..462		3/40 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..575		15/98 (15%)
		BET	571..635	CDD:293640	12/65 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..726		30/101 (30%)
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	38/101 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.860