DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRD3 and fs(1)h

DIOPT Version :9

Sequence 1:	NP_031397.1	Gene:	BRD3 / 8019	HGNCID:	1104	Length:	726	Species:	Homo sapiens
Sequence 2:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster

Alignment Length:	1119	Identity:	413/1119 - (36%)
Similarity:	491/1119 - (43%)	Gaps:	427/1119 - (38%)

- Green bases have known domain annotations that are detailed below.

Human    13 PATPGPVNP-----PPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPD 72
            |....||.|     .||.:....:|||.||||||:...|:|.:|||.|:|||.|||||.||||||
  Fly     8 PRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPD 72

Human    73 YHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKV 137
            ||||||.|||||||||||||||||||.|.:|||||||.|||:||||.:|:|:|||.|||:||||:
  Fly    73 YHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKI 137

Human   138 AQMPQEEVELLPPAPKG---KGRKPA--------AGAQS-AGTQQVAAVSSVSPATPFQSVPPTV 190
            ..||:||:||.|...||   |.|.||        |||.: :||...|..|.....:...||..:.
  Fly   138 ESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAASS 202

Human   191 SQ----------------TP----------VIAATPVPTITANVTSV-----PVPPAAAPPPPAT 224
            :|                ||          .|||.||..:...|:|.     .:||.:..||...
  Fly   203 AQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHTV 267

Human   225 P---------------------------------------------------------------- 225
            |
  Fly   268 PGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAV 332

Human   226 -------------------------IVP------------------------VVPPTPPVVKKKG 241
                                     .:|                        |:||..|...|||
  Fly   333 AAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKKG 397

Human   242 VKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKK-------DLEDGEVP 299
            |||||||||||.:|.     |||....|.|.||:..||||..:.|  .||       .|....||
  Fly   398 VKRKADTTTPTANAF-----ESPYTQMDSKSAKIATRRESNRQVI--GKKGSGYNMSPLGVSGVP 455

Human   300 QHAG-------------KKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDI 351
            ...|             .|.|||:.|:.|:.||:|:.||||:.||||||||||||.|.|||||||
  Fly   456 GLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDI 520

Human   352 IKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMP 416
            ||.||||.|||||||.|||..|..|||||||:|:||||||||||:||||.||||||||||:|.:|
  Fly   521 IKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIP 585

Human   417 DEPVEAPALPAPAAPMVSKG-------------------------------AESSRSSEESSSDS 450
            ||||      |.||.....|                               ..|..|||:||...
  Fly   586 DEPV------ANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDASDSSSEDSSDTE 644

Human   451 GSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKK-------------- 501
            ..|:|:|||:.||..|:.:|..:.|::..||:..  ..|||.:||.|||||
  Fly   645 NESNSDEERSARLKMLESKLLGLQEEIRKLSEEA--SAKKKAKKKLKEKKKSIGGGSGSGSASHH 707

Human   502 ----------------------------------------------------------------K 502
                                                                            .
  Fly   708 CHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPN 772

Human   503 DKEKEKEKHKV------------------------------------------------------ 513
            ......:.|.|
  Fly   773 VGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAG 837

Human   514 -------KAEEEKKAKVAPPAKQAQQKKAPA--------------------------------KK 539
                   |::..:.||.:..........|.|                                |:
  Fly   838 SGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKR 902

Human   540 ANSTTTAGRQLKKGGKQASA-----------------SYDSEEEEEGLPMSYDEKRQLSLDINRL 587
            |..:::||.....||..|||                 ::|||||:...|||||||||||||||:|
  Fly   903 AKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKL 967

Human   588 PGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQ 652
            ||:||||||||||:||||||||||||||||||||||:||||||.||.|||:||       :.||.
  Fly   968 PGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKK-------THKKP 1025

Human   653 AAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSA-----PSGGPSRLSSSSSSESGS 712
            :.|||:|...|||:|||||||||:|||.:|||.|:|::..|:     ....|...|||||..|.|
  Fly  1026 SGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSSSDSSSS 1090

Human   713 SSSSGSSSDSSDSE 726
            |||..|||||||||
  Fly  1091 SSSDSSSSDSSDSE 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRD3	NP_031397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		8/26 (31%)
		Bromo_Brdt_I_like	34..140	CDD:99929	79/105 (75%)
		Acetylated histone H3 binding. /evidence=ECO:0000269\|PubMed:27105114	78..80		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..169		11/31 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..305		33/87 (38%)
		Bromo_Brdt_II_like	311..412	CDD:99930	77/100 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..462		15/71 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..575		36/285 (13%)
		BET	571..635	CDD:293640	58/63 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..726		48/93 (52%)
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	79/105 (75%)
		COG5076	387..>593	CDD:227408	125/218 (57%)
		Bromo_Brdt_II_like	481..581	CDD:99930	77/99 (78%)
		BET	951..1015	CDD:293640	58/63 (92%)
		BRD4_CDT	<2026..2046	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4085
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm41060
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3378
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.800