Protein Alignment CEP290 and MLP2

DIOPT Version :9

• Sequence 1: XP_011537058.1
• Gene: CEP290 / 80184
• HGNCID: 29021
• Length: 2769
• Species: Homo sapiens
• Sequence 2: NP_012117.3
• Gene: MLP2 / 854657
• SGDID: S000001411
• Length: 1679
• Species: Saccharomyces cerevisiae
• Alignment Length: 1877
• Identity: 394/1877 - (20%)
• Similarity: 730/1877 - (38%)
• Gaps: 518/1877 - (27%)

Human  1040 SEGSNVVF---KGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAV 1101
            ||..||.|   :|:..|                    :|::|   .||:...|.|.|:..:...:
Yeast     6 SEFLNVPFESLQGVTYP--------------------VLRKL---YKKIAKFERSEEEVTKLNVL 47

Human  1102 IRHQQSLLY------KEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKV-KEYNNLLNALQMDS 1159
            :...:|..|      |:.|.|....|   .|.|||...|:||:.::..:. :|.:.|...|.:..
Yeast    48 VDEIKSQYYSRISKLKQLLDESSEQK---NTAKEELNGLKDQLNEERSRYRREIDALKKQLHVSH 109

Human  1160 DEMKKILAENSRKITVLQVNEKSLIRQYTTLVE--------LERQLRKENEKQKNELLSMEAEVC 1216
            :.|:             :||::..:::...:.:        |...|.|||:..:.:|:.||
Yeast   110 EAMR-------------EVNDEKRVKEEYDIWQSRDQGNDSLNDDLNKENKLLRRKLMEME---- 157

Human  1217 EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNE--LTAKYRDILQKDNMLVQRTSN 1279
               ..|||.|..||    :||...|.||...||.|.:|:..|  |::..:..|.::   |.::|:
Yeast   158 ---NILQRCKSNAI----SLQLKYDTSVQEKELMLQSKKLIEEKLSSFSKKTLTEE---VTKSSH 212

Human  1280 LEHLECENISLKEQVESI----------NKEL-EITKEKL----HTIEQAWEQETKLGNESSMDK 1329
            :|:||.:...::...||:          ||:| :..:||:    :..:.|..::.:...|.::.|
Yeast   213 VENLEEKLYQMQSNYESVFTYNKFLLNQNKQLSQSVEEKVLEMKNLKDTASVEKAEFSKEMTLQK 277

Human  1330 AKKSITNSDIVSISKKITM--LEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELT 1392
            ....:..|.:.|:.|..::  :|..:.|..:..||...:.|.:.|.|:..:.:|     :...|.
Yeast   278 NMNDLLRSQLTSLEKDCSLRAIEKNDDNSCRNPEHTDVIDELIDTKLRLEKSKN-----ECQRLQ 337

Human  1393 KINLDAQKVEQ--MLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEI 1455
            .|.:|..|.|:  |....::.:|.|..||                 ::|.|.:.|.:  |.|...
Yeast   338 NIVMDCTKEEEATMTTSAVSPTVGKLFSD-----------------IKVLKRQLIKE--RNQKFQ 383

Human  1456 LNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEA 1520
            |..|.:....|:|....:|:.::.::  |||     :|    :|..:|.|.:..|:|.:.|:.|.
Yeast   384 LQNQLEDFILELEHKTPELISFKERT--KSL-----EH----ELKRSTELLETVSLTKRKQEREI 437

Human  1521 YNLRLEQKLDEKE---QALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFS------KT 1576
            .:||  ||::..|   .:|...||:...:.|.|.....:::..   |.||:|.|..|      .:
Yeast   438 TSLR--QKINGCEANIHSLVKQRLDLARQVKLLLLNTSAIQET---ASPLSQDELISLRKILESS 497

Human  1577 MIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEEL 1641
            .|..:||...|:.|        |.:|...:. ||:.|.: ||::.::
Yeast   498 NIVNENDSQAIITE--------RLVEFSNVN-ELQEKNV-ELLNCIR------------------ 534

Human  1642 RLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLD 1706
                      ::.||     |.|...:.::|:..:|.:.:::.|          ...::||.
Yeast   535 ----------ILADK-----LENYEGKQDKTLQKVENQTIKEAK----------DAIIELEN--- 571

Human  1707 IFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEK 1771
                     :||                           |::..|.|:|..|.:.|.|....:.|
Yeast   572 ---------INA---------------------------KMETRINILLRERDSYKLLASTEENK 600

Human  1772 ESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEM--EPKSHHTLKIAHQTIANMQA 1834
            .:...:.... .:|:|.|.||...|.:|......|.:..|||:  ..||....|...:...|.:.
Yeast   601 ANTNSVTSME-AAREKKIRELEAELSSTKVENSAIIQNLRKELLIYKKSQCKKKTTLEDFENFKG 664

Human  1835 RLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWD---LMKQ 1896
            ...:||.:|::....|:...|:|:..|..:   :|:...|...:...|..|.|...::   |.|:
Yeast   665 LAKEKERMLEEAIDHLKAELEKQKSWVPSY---IHVEKERASTELSQSRIKIKSLEYEISKLKKE 726

Human  1897 SPTPVPTNKHF---------------IRLAEMEQTVAEQDDSLSS----LLVKLKKVSQDLERQR 1942
            :.:.:||.:..               :||.|.|.:..|.....||    ...|:|::..:|||.|
Yeast   727 TASFIPTKESLTRDFEQCCKEKKELQMRLKESEISHNENKMDFSSKEGQYKAKIKELENNLERLR 791

Human  1943 EITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKY---LLDQSQKESQCLKSELQAQKEANSR 2004
            ...:.|::|.|:|:              ..:...||:   .:|.::.:.:.|.:|| :.||
Yeast   792 SDLQSKIQEIESIR--------------SCKDSQLKWAQNTIDDTEMKMKSLLTEL-SNKE---- 837

Human  2005 APTTTMRNL---VERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQI 2066
               ||:..|   :|.|..:|...:.|.|.|.:           .::...:..|.:||
Yeast   838 ---TTIEKLSSEIENLDKELRKTKFQYKFLDQ-----------NSDASTLEPTLRKE-------- 880

Human  2067 VDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYN-KILREKEEI 2130
                ..:::.|::|.|..:...:|.:.:::|.       |.:|.|||.|.::.|: ||..||:|.
Yeast   881 ----LEQIQVQLKDANSQIQAYEEIISSNENA-------LIELKNELAKTKENYDAKIELEKKEK 934

Human  2131 DQENDELKR------QIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVD--LKPM 2187
            ....::|.|      :|:.|...|:...|...:||  |:|:.:|::::..:| |:|::.  ::..
Yeast   935 WAREEDLSRLRGELGEIRALQPKLKEGALHFVQQS--EKLRNEVERIQKMIE-KIEKMSTIVQLC 996

Human  2188 KEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADK----EKLTLQ 2248
            |:|...:.....:|.|.....:..:.....:.:.|:......|.:.:||..|.::    ||...:
Yeast   997 KKKEMSQYQSTMKENKDLSELVIRLEKDAADCQAELTKTKSSLYSAQDLLDKHERKWMEEKADYE 1061

Human  2249 RKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRD---------SVVED 2304
            |:|         :..|...||           |.:||.:|..:.......:         |:..:
Yeast  1062 REL---------ISNIEQTES-----------LRVENSVLIEKVDDTAANNGDKDHLKLVSLFSN 1106

Human  2305 LHLQNRYLQEKLHALEKQFSKDTYSKPSQNQISGIESDDHCQREQELQKENLKLSSENIELKFQL 2369
            |..:...|:.||...:::.:   :.|...:.:....:|  .||.|.|.::..:.|:..|: :|
Yeast  1107 LRHERNSLETKLTTCKRELA---FVKQKNDSLEKTIND--LQRTQTLSEKEYQCSAVIID-EF-- 1163

Human  2370 EQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKV 2434
                ||:.:...||..|||       ..|.:|:.|.:|....|      |:.|.:...::.:.::
Yeast  1164 ----KDITKEVTQVNILKE-------NNAILQKSLKNVTEKNR------EIYKQLNDRQEEISRL 1211

Human  2435 QRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKII------ 2493
            ||:..|.|:...| .|.|:...|.|.|:.|...:.|.       ....:::.|..||:.
Yeast  1212 QRDLIQTKEQVSI-NSNKILVYESEMEQCKQRYQDLS-------QQQKDAQKKDIEKLTNEISDL 1268

Human  2494 ------AEN---------ERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES 2543
                  |||         .||:|:..::.||::|.:.|..|  .|||...::
Yeast  1269 KGKLSSAENANADLENKFNRLKKQAHEKLDASKKQQAALTN--ELNELKAIK------------- 1318

Human  2544 RGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDL------KQLVKEATEREQKVNK 2602
                                      .:||.|:..:|..:.||      .:|..|...|:.:.:.
Yeast  1319 --------------------------DKLEQDLHFENAKVIDLDTKLKAHELQSEDVSRDHEKDT 1357

Human  2603 YNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDK-EKAELIHQIEANKDQSGAESTIP 2666
            |...:|:              .:.||:|||:.:.||...|. ||.::  .:|..||:...|.|
Yeast  1358 YRTLMEE--------------IESLKKELQIFKTANSSSDAFEKLKV--NMEKEKDRIIDERT-- 1404

Human  2667 DADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKE-LENFDPSFFEEIEDLKYNYKEEVKKNIL 2730
                 ||..|.|:..|..|...:....::|:.|||| |:.::......|::.:.|.|:.::  :.
Yeast  1405 -----KEFEKKLQETLNKSTSSEAEYSKDIETLKKEWLKEYEDETLRRIKEAEENLKKRIR--LP 1462

Human  2731 LEEKVKKLSEQLGVELTSPVAASEEF--------------------EDEEESPVNFP 2767
            .||:::|:..:...||      .|||                    ||.||...|.|
Yeast  1463 SEERIQKIISKRKEEL------EEEFRKKLKENAGSLTFLDNKGSGEDAEEELWNSP 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CEP290	XP_011537058.1	SMC_prok_B	843..1562	CDD:274008	126/563 (22%)
		SMC_prok_B	1369..2176	CDD:274008	177/854 (21%)
		CEP209_CC5	1576..1703	CDD:293182	20/126 (16%)
		Smc	1927..2683	CDD:224117	168/811 (21%)
		DUF342	<2067..2151	CDD:302792	22/90 (24%)
MLP2	NP_012117.3	SMC_prok_B	59..988	CDD:274008	245/1149 (21%)
		Smc	591..1417	CDD:224117	210/1001 (21%)
		PTZ00108	<1309..1670	CDD:240271	59/277 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6647
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950