DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CEP290 and spo15

DIOPT Version :9

Sequence 1:XP_011537058.1 Gene:CEP290 / 80184 HGNCID:29021 Length:2769 Species:Homo sapiens
Sequence 2:NP_593009.1 Gene:spo15 / 2541649 PomBaseID:SPAC1F3.06c Length:1957 Species:Schizosaccharomyces pombe


Alignment Length:2279 Identity:492/2279 - (21%)
Similarity:936/2279 - (41%) Gaps:543/2279 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   545 LEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDL-LSLKNMSEAQSK 608
            ||..|.::.:.......|.|..|:....::|:|...| :....|.|:..:|. |.....|.|.|.
pombe    35 LETPRPNISRASTGQLAEDGDTSSQHEDSSEELKRQE-VRGMRRHSDLSIDAKLGSSEGSTASSA 98

Human   609 I----RSSDKAE-LLHRRSSFNTPQSDQNE-TEENMTIGSLSRM---LSEIHHSVESGMHPFVPL 664
            :    ||...|. ||.|....::|..|.|. |:::..:..|.::   |:.:.|  |:|:   :.|
pombe    99 LPLTPRSPSNASWLLVRGGLLDSPILDINSVTQKSNLLNELKQVRSKLAALEH--ENGI---LSL 158

Human   665 TRLSSSMQVKENSTPETITIRE---IFKAPCLQSSRNLESLVSTFSRESHEEINDICLFSDDCMK 726
            ...||:.:.|..|:..|:|..|   .|:    :...|:||..|....|:::....:...::...|
pombe   159 QLSSSNKKDKNTSSVTTLTSEEDVSYFQ----KKLTNMESNFSAKQSEAYDLSRQLLTVTEKLDK 219

Human   727 KVSRSHQALEKTSFV-------QKSNSSFHGLSTASDIMQKLSLRQKSAIFCQQIHEN--RAD-- 780
            |.....:..|..|.:       |.||.|..|   ..:.::||.:.....:...:..||  ||:  
pombe   220 KEKDYEKIKEDVSSIKASLAEEQASNKSLRG---EQERLEKLLVSSNKTVSTLRQTENSLRAECK 281

Human   781 -----MDKSQV----ATLEEEQVHSQVKYADI-----NLKEDI---------IKSEVPLQTEILK 822
                 ::|..:    :.|.||..|:...|:|.     .|.||:         :|||  ..|..:|
pombe   282 TLQEKLEKCAINEEDSKLLEELKHNVANYSDAIVHKDKLIEDLSTRISEFDNLKSE--RDTLSIK 344

Human   823 N-KLKVNLPDPVSITAQSKLSQINSLENLIEQLRRELVFLRSQNEIIAQEFLIKEAECRNADIEL 886
            | ||:..|.:.:.....|:.|  ||      ||..|:|.|:..|..|..:  :.:||.:.:..|.
pombe   345 NEKLEKLLRNTIGSLKDSRTS--NS------QLEEEMVELKESNRTIHSQ--LTDAESKLSSFEQ 399

Human   887 EHHRSQAE----QNEFLSRELIEKE--RDLERSRTVIAKFQNKLKELVEE----NKQLEEGMKEI 941
            |:...:..    ||...|::.:.|:  ..||.:|:.:|....||.|:..|    ||:::: .::|
pombe   400 ENKSLKGSIDEYQNNLSSKDKMVKQVSSQLEEARSSLAHATGKLAEINSERDFQNKKIKD-FEKI 463

Human   942 LQAIKEMQKDPDVKGGETSLIIPSLERLVNAI-----ESKNAEGIFDASLHLKAQVDQLTGRNEE 1001
            .|.::........:..|.|.:|...::.:|.:     |.|.......:||. ..|.|.|   ||:
pombe   464 EQDLRACLNSSSNELKEKSALIDKKDQELNNLREQIKEQKKVSESTQSSLQ-SLQRDIL---NEK 524

Human  1002 LRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINS 1066
            .:.|:.||:...:....|...:|  .:||..:.|.| .:|....|....:|.:. ..|..::.|:
pombe   525 KKHEVYESQLNELKGELQTEISN--SEHLSSQLSTL-AAEKEAAVATNNELSES-KNSLQTLCNA 585

Human  1067 QNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEK 1131
            ..|.|...:.:|:..|:...:|:.|.:..|..     ||:.         :...:|.:|.:|:..
pombe   586 FQEKLAKSVMQLKENEQNFSSLDTSFKKLNES-----HQEL---------ENNHQTITKQLKDTS 636

Human  1132 RKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQ 1196
            .||: |:|.:....::..:.|      |||...:    ..|:..|:.:.||||::...:..||:.
pombe   637 SKLQ-QLQLERANFEQKESTL------SDENNDL----RTKLLKLEESNKSLIKKQEDVDSLEKN 690

Human  1197 LR--KENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNEL 1259
            ::  ||:.::..|.|              ||.::   :...|::|:||  ...:.|....|.|:|
pombe   691 IQTLKEDLRKSEEAL--------------RFSKL---EAKNLREVIDN--LKGKHETLEAQRNDL 736

Human  1260 TAKYRDILQKDNML-VQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGN 1323
            .:...|....:.:| .:.|.:.|.::    .|...||::.::.:..|:...::..:::..:.|.:
pombe   737 HSSLSDAKNTNAILSSELTKSSEDVK----RLTANVETLTQDSKAMKQSFTSLVNSYQSISNLYH 797

Human  1324 ESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT---SLKQMEERNFELE 1385
            |...|.......|:         |:||    :|.:....|:.:.:...|   :::::..::...|
pombe   798 ELRDDHVNMQSQNN---------TLLE----SESKLKTDCENLTQQNMTLIDNVQKLMHKHVNQE 849

Human  1386 TKFAELTKIN----LDAQKVEQMLRDELADSVSKAVSDADR--QRILELEKNEMELKVEVSKLRE 1444
            :|.:||.::|    ||.:        .|..|::.|:||.|:  .::.||.||...|:.|      
pombe   850 SKVSELKEVNGKLSLDLK--------NLRSSLNVAISDNDQILTQLAELSKNYDSLEQE------ 900

Human  1445 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLE 1509
                        :||..|..|.:|:             ||.|   ||..|..|.:       :|:
pombe   901 ------------SAQLNSGLKSLEA-------------EKQL---LHTENEELHI-------RLD 930

Human  1510 SITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFS 1574
            .:|.||:..|:.:..|.:||..:::.:...:.|..:::    |.|.|::.:.        .|..|
pombe   931 KLTGKLKIEESKSSDLGKKLTARQEEISNLKEENMSQS----QAITSVKSKL--------DETLS 983

Human  1575 KTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGL----EELISTLKDTKGAQKVINWH 1635
            |      :.||:       :..||  ::||..|:|::...|    |.|:..||:  ..:.:.:..
pombe   984 K------SSKLE-------ADIEH--LKNKVSEVEVERNALLASNERLMDDLKN--NGENIASLQ 1031

Human  1636 MKIEELRLQELKLNRELVKDKEEIKYLNNIISEYER--TISSLEEEIVQQNKFHEERQMAWDQRE 1698
            .:||:.|.:...|..:          |:.:.||||.  .|||      |.||..|::.......|
pombe  1032 TEIEKKRAENDDLQSK----------LSVVSSEYENLLLISS------QTNKSLEDKTNQLKYIE 1080

Human  1699 VDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKS 1763
            .::::.||..|::..|:.....|:    |.:.:.:..:.::| :||||..:      :....|.:
pombe  1081 KNVQKLLDEKDQRNVELEELTSKY----GKLGEENAQIKDEL-LALRKKSK------KQHDLCAN 1134

Human  1764 LEEKLKEKESALRLAEQNILSRDKVINELRLRL-PATAEREKLIAELGRKEMEPKSHHTLKIAHQ 1827
            ..:.||||..||   ||  |:.:|  |||.:.| .:.:..|.|:.|  |.::..:          
pombe  1135 FVDDLKEKSDAL---EQ--LTNEK--NELIVSLEQSNSNNEALVEE--RSDLANR---------- 1180

Human  1828 TIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL-----HILHHRLEL-----QADSS 1882
             :::|:..|:..:.|:...:..|.:..:| .:.:||.::.|     .:...|.:|     ..:.|
pombe  1181 -LSDMKKSLSDSDNVISVIRSDLVRVNDE-LDTLKKDKDSLSTQYSEVCQDRDDLLDSLKGCEES 1243

Human  1883 LNKFKQTAWDLMKQSPTPVPTNK-----------HFIRLAEMEQTV-----------------AE 1919
            .||:..:..:|..:|...||.::           :|..|:.:  ||                 .|
pombe  1244 FNKYAVSLRELCTKSEIDVPVSEILDDNFVFNAGNFSELSRL--TVLSLENYLDAFNQVNFKKME 1306

Human  1920 QDDSLSSLLVKLKKVSQDLER-QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQ 1983
            .|:.|::...:..||..|||: |.|..:..::. .:::..|:::.::.::| :||:.:..:.|::
pombe  1307 LDNRLTTTDAEFTKVVADLEKLQHEHDDWLIQR-GDLEKALKDSEKNFLRK-EAEMTENIHSLEE 1369

Human  1984 SQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE---KQQKAL-------------- 2031
            .::|::...:||.::.|.|..| |..::|.::.|..::.|||   |::::|              
pombe  1370 GKEETKKEIAELSSRLEDNQLA-TNKLKNQLDHLNQEIRLKEDVLKEKESLIISLEESLSNQRQK 1433

Human  2032 SRALLELRAEMTAAAEERIISATSQKEAHL-----NVQQIVDRHTRELKTQVEDLNENLLKLKEA 2091
            ..:||:.:.|:     |.::..||:|.:.|     ::...:|..:.||.:.||.|.        |
pombe  1434 ESSLLDAKNEL-----EHMLDDTSRKNSSLMEKIESINSSLDDKSFELASAVEKLG--------A 1485

Human  2092 LKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN-DELKRQIKRLTSGLQGKPLTD 2155
            |:...:...||.:|   :.::||:        .:||.::|:.. .||..:|....:..:||  .:
pombe  1486 LQKLHSESLSLMEN---IKSQLQE--------AKEKIQVDESTIQELDHEITASKNNYEGK--LN 1537

Human  2156 NKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKE 2220
            :|.|:|.:|...:::|.|.|           .:||:|                   ::....|||
pombe  1538 DKDSIIRDLSENIEQLNNLL-----------AEEKSA-------------------VKRLSTEKE 1572

Human  2221 GEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLEN 2285
            .|:.....:|..|:  :.|:..|....:.|||....|.:..|      :|.|...|..|.|||:|
pombe  1573 SEILQFNSRLADLE--YHKSQVESELGRSKLKLASTTEELQL------AENERLSLTTRMLDLQN 1629

Human  2286 DILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSQNQISGIESDDHCQREQE 2350
            .:..:    :..:||:.|||... |.|::.:.:|:|:      .|...|.:            :.
pombe  1630 QVKDL----SNIKDSLSEDLRTL-RSLEDSVASLQKE------CKIKSNTV------------ES 1671

Human  2351 LQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFL--KKEKAEVQRKLGH---VRGS 2410
            ||.....:.:.|.||:       .::.|..:::|...:.||.|  |.:|...|.:..|   .|..
pombe  1672 LQDVLTSVQARNAELE-------DEVSRSVDKIRRRDDRCEHLSGKLKKLHSQLEEQHETFFRAE 1729

Human  2411 GRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEK-MANIEQENEKLKAELEKLKAHL 2474
            .:....:..|::|:...:|:::|:....|||...|.||..|. :.:||:|...|:..|..::  |
pombe  1730 QQRMTQLGFLKETVKKQEKLLKKLNLRQEQLIPRSSILVYESYIRDIEKEIIVLQERLNGIE--L 1792

Human  2475 GHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQ 2539
            ..||...|......|.::                          .:|:|:     ..::...:||
pombe  1793 SQQLPKGYFGYFFKTNRV--------------------------EMEVLD-----SFKQQVAKLQ 1826

Human  2540 FAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYN 2604
            |       |.||:            :..|.||             ||::...|..|::...:.|:
pombe  1827 F-------LAGAE------------FIVKFKE-------------DLEKCAAEEKEKQATFDNYS 1859

Human  2605 EDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQL---DKEK----AELIHQIE-ANKDQSGA 2661
            |.:|...|.::.:......|...::.|.:.:.|.|.|   |..|    :::.:.|. .|..||..
pombe  1860 EKVENLGKSIEALYFALNREISFRKSLALSKSAYHNLLVRDSPKFNPDSQITYSIPVTNTKQSLL 1924

Human  2662 ESTI 2665
            .|.|
pombe  1925 RSAI 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CEP290XP_011537058.1 SMC_prok_B 843..1562 CDD:274008 159/745 (21%)
SMC_prok_B 1369..2176 CDD:274008 192/884 (22%)
CEP209_CC5 1576..1703 CDD:293182 30/132 (23%)
Smc 1927..2683 CDD:224117 165/777 (21%)
DUF342 <2067..2151 CDD:302792 19/84 (23%)
spo15NP_593009.1 PRK03918 <176..723 CDD:235175 138/618 (22%)
SMC_prok_B 455..1236 CDD:274008 206/976 (21%)
Mplasa_alph_rch 881..1539 CDD:275316 173/806 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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