Protein Alignment CEP290 and mto1

DIOPT Version :9

• Sequence 1: XP_011537058.1
• Gene: CEP290 / 80184
• HGNCID: 29021
• Length: 2769
• Species: Homo sapiens
• Sequence 2: NP_588284.1
• Gene: mto1 / 2539467
• PomBaseID: SPCC417.07c
• Length: 1115
• Species: Schizosaccharomyces pombe
• Alignment Length: 1209
• Identity: 237/1209 - (19%)
• Similarity: 485/1209 - (40%)
• Gaps: 310/1209 - (25%)

Human  1750 NIRIILETRATCKSLEEKLK-----EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAEL 1809
            |..::::..|.....:|:::     .||.:.:|....  |:|:...|...:.....:|:.|.::.
pombe    12 NFNVLVDNLAGLSLTDEEVRRILSPRKEGSRQLPSST--SKDEDSEEASHKYDFEIDRDSLKSDS 74

Human  1810 GRKEME-----PKSHHTLKIAHQTIANMQARLNQKEEV-----------LKKYQRLLEKAREEQR 1858
            |...:.     |.|...|:...:::    .:||.::|.           ...:.||.:....:..
pombe    75 GSPRLHQNATAPTSSTPLQSPDESV----NKLNSEDEEGNSSVAPFFLDTTNFDRLNDNITTDDE 135

Human  1859 EI------------VKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP----------TPV 1901
            ::            .:::|||   .::..:..:|.|...:..::.|   |.|          ||:
pombe   136 QLSPVLTANQGFQSQEQYEED---SYNNYDYTSDPSSPNYISSSLD---QLPHLDDEDDLQLTPI 194

Human  1902 PTNKHFIRLAEMEQTVAEQDDSLSSLLV----------KLKKVSQDLERQREITELKVKEFENI- 1955
            ...::::...:...|.| ....:|.:|:          :...::::.|..:..:.|.:||..|:
pombe   195 KEERNYLHSQDAPTTNA-LSKKISDILIPASAMKDLKDRKNALAKEFEESQPGSSLTLKEQANVI 258

Human  1956 ----------KL-------QLQENHEDEVKKVKAEVEDLKYLLDQSQ-------KESQCLKSELQ 1996
                      ||       ||.:.|:.||:.:..:..|||.|..:.|       |:...|:|.::
pombe   259 DNLRKEVFGLKLKCYFLYDQLNKFHDQEVQDIMKQNIDLKTLTMELQRAVAGYEKKISGLESRIK 323

Human  1997 AQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALS------RALLELRAEMTAAAEERIISATS 2055
            ..:..|...|:....||:       .|:.:..:|||      ||...||.|   .:::...|..:
pombe   324 PDQSFNLSTPSPAPSNLI-------TLQSRYSQALSELETTKRAFAALRKE---KSKKTNYSVGA 378

Human  2056 QKEAHLNVQQIVDRHTRELKTQVEDLNENLLKL-KEALKTSKNRENSLTDNLNDLNNELQKKQKA 2119
            ..|....:..::|...||.:..:::|....::| |:....:||.:..:.:.|...|..|:.....
pombe   379 YNEDRNVLSNMLDNERREKEALLQELESLRVQLSKKVPMPAKNTDERVIETLQRSNELLRMDISM 443

Human  2120 YNKILREKEEIDQENDELKRQIKRLTSGLQGKPLT------DNKQSLIEELQRKVKKLENQLEGK 2178
            .|:.|..::   ||||.|.:|::.||..|....:.      .:|..|.:.:.  |.:::.| |..
pombe   444 QNEALLLRK---QENDRLVKQVEELTVALNSGKMNAIVEAESSKNELWDSMM--VSRMKTQ-EQS 502

Human  2179 VEEVDL-KPMK--EKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKA 2240
            :|...| |.::  |::.:.:|:|.|:  :|:..::.::..::|       :|::|...|::.:|:
pombe   503 IELTRLYKQLQDIEEDYENKLMRMEQ--QWREDVDQLQEYVEE-------ITQELQDTKEVLSKS 558

Human  2241 DKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDL 2305
            .||           ....::|:|....|:|:|:|:.:|...:.|..|...:.......|.:.:
pombe   559 SKE-----------SDDYEEVVGKLRTEAEREIEKFEKTIRENEESISLFKEEVEKLTDEITQ-- 610

Human  2306 HLQNRY---------LQEKLHALEKQFSK---DTYSKPSQ--NQISGIESD-DHCQREQE----- 2350
             |..||         ||::|..||::.:|   |:.||.|.  .|:...|:: |..::|.|
pombe   611 -LSERYNDKCHEFDELQKRLQTLEEENNKAKEDSTSKTSNLLEQLKMTEAEVDSLRKENEENKQV 674

Human  2351 --LQKENLKLSSEN-IELKFQLEQANKDLPRLKNQVRDL----KEMCEFLKKEKAEVQRKLGHVR 2408
              |::..|..|::| :.|..|:|..|..|.:||.::..:    :.:.::|.
pombe   675 IALKESELVKSNDNKLLLNEQIESLNDQLSQLKTEMESVTTSKESLADYLS-------------- 725

Human  2409 GSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEK--MANIEQENEK---LKAELE 2468
                            .|.::..:::...|::|::..|||:|..  .:.||:.|.:   |:...:
pombe   726 ----------------NLKERHNDELDSLNKKLREFEGILSSNSSLKSEIEERNNQYVTLRENFD 774

Human  2469 KLK----------------AHLGHQLSMHYESKTK---GTEKIIAENERLRKELKKETDAAEKLR 2514
            .|:                .||..|:....:...|   ||:|::.:.....:.||::|::.|.|.
pombe   775 SLQNAIMETFDKQVTHCSVNHLVQQIRKLKDENKKDQSGTDKLMKKIYHCEQSLKEKTNSLETLV 839

Human  2515 IAKNNLEIL-----NEKMTVQLEETGKRLQFAESRG--PQLEGADSKSWKSIVVTRMYETKL--- 2569
            ..|..|:.|     ..|..:|||     |:...|:.  ..|.|:.|.|.:|    :..|.||
pombe   840 SEKKELKNLLDAERRSKKAIQLE-----LENLSSQAFRRNLSGSSSPSERS----QSRELKLLQA 895

Human  2570 --KELETDIAKKNQSITDLKQLVKEATE--------------------REQKVNKYNEDLEQQIK 2612
              |.|:..:.::|..|   |.:|...|:                    ..|.||....:|::.|:
pombe   896 SEKRLKEQVEERNSLI---KNIVTRFTQLNTGSKPVNTNVEALTTISSMNQAVNMNFRELDKSIQ 957

Human  2613 ILKHVPEGAETEQGLKRELQ----VLRLANHQLD--KEKAELIHQIEANKDQSGAESTIPDADQL 2671
            ..|...:..|.|  .|.||:    ||...:.:|.  :|:.:|:        .:|:.|:||::.:.
pombe   958 EFKRKCQSMERE--FKTELRKLDGVLEARSKRLSQLEERVKLL--------GAGSTSSIPNSPRA 1012

Human  2672 KEKIK-DLE-TQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEE---------- 2724
            .:::. |.| .:|..:..:|..::..|..||::.|.....:...:.::::..|.|
pombe  1013 SKRVSLDSEDKKLVPASPDKSAVQRGITALKRDAEGMSHIWQLRLREMEFQLKAEQEGRKRDKLG 1077

Human  2725 --------VKKNILLEEKVKKLSEQLGVELTSPVAASEE 2755
                    :::|..|..::|...|.   ...||..:|:|
pombe  1078 ARERLQDLIRQNRSLSRQIKTDKES---NSRSPSISSQE 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CEP290	XP_011537058.1	SMC_prok_B	843..1562	CDD:274008
		SMC_prok_B	1369..2176	CDD:274008	95/516 (18%)
		CEP209_CC5	1576..1703	CDD:293182
		Smc	1927..2683	CDD:224117	188/897 (21%)
		DUF342	<2067..2151	CDD:302792	22/84 (26%)
mto1	NP_588284.1	Cnn_1N	252..319	CDD:285263	16/66 (24%)
		Fib_alpha	511..611	CDD:285864	22/122 (18%)
		Mto2_bdg	1052..1101	CDD:289572	5/48 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000