DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CEP290 and Cep290

DIOPT Version :9

Sequence 1:	XP_011537058.1	Gene:	CEP290 / 80184	HGNCID:	29021	Length:	2769	Species:	Homo sapiens
Sequence 2:	XP_006513589.1	Gene:	Cep290 / 216274	MGIID:	2384917	Length:	2756	Species:	Mus musculus

Alignment Length:	2772	Identity:	2331/2772 - (84%)
Similarity:	2561/2772 - (92%)	Gaps:	19/2772 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPPNINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQE 65
            |||||.|||::|||||||||||||||.||||||||||||||:|.|||:|||||||||||||||||
Mouse     1 MPPNIKWKELIKVDPDDLPRQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQE 65

Human    66 VELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRE 130
            |||||||||||||||||||||||||||||||||||||||||||||||||:||.||||||||||||
Mouse    66 VELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRE 130

Human   131 LEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLL 195
            ||||||||:||||||||||||||||||||||||||       ||||.|||||||||||||||:||
Mouse   131 LEDMEKELDKEKKVNEQLALRNEEAENENSKLRRE-------NEQLRQDIIDYQKQIDSQKESLL 188

Human   196 SRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRM 260
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
Mouse   189 SRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRM 253

Human   261 KAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEII 325
            ||:|||:|.|:||:||||:||:|||:|||||||:|:|||||:|:|||||||||||||||||||||
Mouse   254 KALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEII 318

Human   326 EYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKN 390
            ||||||.:||.|||||||||||||:|||:||||||||||||||||||||||||||||.|||||||
Mouse   319 EYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKN 383

Human   391 ELQRNKGASTLSQQTH-MKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESG 454
            |||::||.|...|||| |||.|.:.||:||||||||.||||||||||||||||||||||||||||
Mouse   384 ELQKDKGTSNFYQQTHYMKIHSKVQILEEKTKEAERIAELAEADAREKDKELVEALKRLKDYESG 448

Human   455 VYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
            ||||||||:||||||.||||||.|:|:|||||||||:||:|.||||||||||.||||||||||||
Mouse   449 VYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTE 513

Human   520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENIS 584
            |||||.|||||||||||:||||||||||||||||:||||||||||||:|.||||.:||||:|..|
Mouse   514 FRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGLTIDDLNLSETFS 578

Human   585 QGDRISERKLDLLSLKNMSEAQSKIRSSDKAELLHRRSSFNTPQSDQNETEENMTIGSLSRMLSE 649
            ..::|..|||:.:||.||:|.||||:||.|.||||||.||:..||||:|.||||...|||||||.
Mouse   579 HENKIEGRKLNFMSLNNMNETQSKIKSSAKTELLHRRPSFSVVQSDQSEAEENMATRSLSRMLSG 643

Human   650 IHHSVESGMHPFVPLTRLSSSMQVKENS-TPETITIREIFKAPCLQSSRNLESLVSTFSRESHEE 713
            ||.||.|...|.|.|||.||.||||::| |||.||||||||||||:|.|.|||||||||::..||
Mouse   644 IHQSVGSAGDPIVSLTRCSSFMQVKDSSATPEAITIREIFKAPCLRSLRKLESLVSTFSKDGSEE 708

Human   714 IND-ICLFSDDCMKKVSRSHQALEKTSFVQKSNSSFHGLSTASDIMQKLSLRQKSAIFCQQIHEN 777
            ::: :|..|||.||:.|.:|:.||||.|:|||:|||.....|:::|||||.||.||||.||.::.
Mouse   709 LSEYLCSLSDDHMKRGSGNHRGLEKTRFLQKSSSSFQVSPAAAELMQKLSHRQSSAIFPQQSYDR 773

Human   778 RADMDKSQVATLEEEQVHSQVKYADINLKEDIIKSEVPLQTEILKNKLKVNLPDPVSITAQSKLS 842
              |:||   .|.|:.||:||:::|.::||:|..:||:|.|||:|.:|.:|||.|.|.||||||.|
Mouse   774 --DVDK---VTSEDNQVYSQIEHAVLSLKDDKGQSELPSQTEMLSSKTQVNLSDLVPITAQSKPS 833

Human   843 QINSLENLIEQLRRELVFLRSQNEIIAQEFLIKEAECRNADIELEHHRSQAEQNEFLSRELIEKE 907
            .|:.||.||.|.:|:|.|||||||.|.|:..|:|.:.|||::||:|.||||||||||||||.|||
Mouse   834 LIHPLEKLIGQPQRQLAFLRSQNETIVQDLPIQEEQSRNAELELDHQRSQAEQNEFLSRELAEKE 898

Human   908 RDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA 972
            :|||||||||||||:||||||||||||||||||||||||:|.||.||||||||||||||||||||
Mouse   899 KDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNA 963

Human   973 IESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLL 1037
            :||||||||||||||||||||||||||||||||||:|||||:||||||.|||||||||||||.||
Mouse   964 MESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLL 1028

Human  1038 RQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVI 1102
            |||.|||||:||||||||||||||.||||||||||||||||:|||||||:|||||||||||||||
Mouse  1029 RQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVI 1093

Human  1103 RHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILA 1167
            |||||||||||||||:.|||:|:.|:|||||||||.:|||:|||||||||:||||||:||||:|:
Mouse  1094 RHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLS 1158

Human  1168 ENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFK 1232
            |||||||||||||||||||||||||:||.|||||.|.:|::::|||||.||:|.|||||||||||
Mouse  1159 ENSRKITVLQVNEKSLIRQYTTLVEMERHLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIFK 1223

Human  1233 IAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESI 1297
            |||||||:||||||||||||||||||||.||||||||||||||||||||||||||.|||||:|:|
Mouse  1224 IAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQRTSNLEHLECENASLKEQMEAI 1288

Human  1298 NKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEH 1362
            :|||||||||||||||||||||||||:|:|||||||:|||||||||||||:||||||||||||||
Mouse  1289 SKELEITKEKLHTIEQAWEQETKLGNDSNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEH 1353

Human  1363 CQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILE 1427
            ||||||||||||||||||||||||||.||||||||||||||||||||||||:|||||||||||||
Mouse  1354 CQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILE 1418

Human  1428 LEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQ 1492
            |||:|:||||||||||||||||:|||:.||:|||||:|||||||.||||:|||||||:|||||||
Mouse  1419 LEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQ 1483

Human  1493 HNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL 1557
            |.||||:|||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1484 HVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL 1548

Human  1558 RRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTL 1622
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
Mouse  1549 RRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTL 1613

Human  1623 KDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFH 1687
            ||.:|||||||||:||||||||||||||||||.|||||||||||||||.||:|||||||||:|||
Mouse  1614 KDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFH 1678

Human  1688 EERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIR 1752
            ||||||||||||:|||||||||.||||||:||||||::|||:||||||||||||||||||||||:
Mouse  1679 EERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDSTGSMPDPSLPLPNQLEIALRKIKENIQ 1743

Human  1753 IILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK 1817
            :||:|:||||||||||||||||||||||||||||||||||||||||||:||||||||.|||:|||
Mouse  1744 VILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEPK 1808

Human  1818 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSS 1882
            ||||:|||||||||||||||.|||||||||.|||||||||||||||||||||:|||:||.|||:|
Mouse  1809 SHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNS 1873

Human  1883 LNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITEL 1947
            ||||:|||.||:||||.|||||||||||||||||||||||||||||.||||||:|||:|:|||||
Mouse  1874 LNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITEL 1938

Human  1948 KVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRN 2012
            ||:||||.||:|||.|..||||||||||||::.|.|:.|:||.||||||||||||||||||||||
Mouse  1939 KVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRN 2003

Human  2013 LVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQ 2077
            ||:||||||||||||||||||||||||:|||||||||||:.||||||:|||||:|:|||||||:|
Mouse  2004 LVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQ 2068

Human  2078 VEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIK 2142
            :|||||||||||||||||||:||||.|:||:|||||||||||||||||||:.||||||||:||||
Mouse  2069 IEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIK 2133

Human  2143 RLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQA 2207
            ||:||||.|.|.|||||||:|||:||||||:|||.||::||:||:|||::||||||||||||||.
Mouse  2134 RLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKWQT 2198

Human  2208 KIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE 2272
            |:||:||:|||||||...|.|||||||:|||||||||||||:||||||||||||||:||||||||
Mouse  2199 KVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTTGMTVDQVLGVRALESEKE 2263

Human  2273 LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSQNQIS 2337
            ||||||:||||||||||||..||||||||||||||||:|||||||.|||:.||:.|   ||:..|
Mouse  2264 LEELKKKNLDLENDILYMRTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLSKEKY---SQSLTS 2325

Human  2338 GIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQR 2402
            .||||||||:||||||||||||||||||||||||||||||||||||:|||||||||||.|.|::|
Mouse  2326 EIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELER 2390

Human  2403 KLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAEL 2467
            |||.|||:||||||||||||||||||||||||||||||||||||||||||||.||:||..|||||
Mouse  2391 KLGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAEL 2455

Human  2468 EKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 2532
            ||||||.|.||||.:|||.||||||:|||||||||||||.:|:|||||||||||::|:||..|||
Mouse  2456 EKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLE 2520

Human  2533 ETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATERE 2597
            ||||||||||||.||||||||||||||||:|:||||:||||:||||||||||||||||:||||||
Mouse  2521 ETGKRLQFAESRAPQLEGADSKSWKSIVVSRVYETKMKELESDIAKKNQSITDLKQLVREATERE 2585

Human  2598 QKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAE 2662
            ||..||.|||||||:|||:|||||||||.|.||||:|||||:|:|||:||||||||.||||:.|:
Mouse  2586 QKAKKYTEDLEQQIEILKNVPEGAETEQELIRELQLLRLANNQMDKERAELIHQIEINKDQTRAD 2650

Human  2663 STIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKK 2727
            |:|||:|||||||.||||||:..:|||||.|||:|||||||||||||||||||||||||||||||
Mouse  2651 SSIPDSDQLKEKINDLETQLRKLELEKQHSKEEVKKLKKELENFDPSFFEEIEDLKYNYKEEVKK 2715

Human  2728 NILLEEKVKKLSEQLGVELTSPVAASEEFEDEEESPVNFPIY 2769
            |||||||:||||||.|.||.||:||||..|| .|||.:||||
Mouse  2716 NILLEEKLKKLSEQFGFELPSPLAASEHSED-GESPHSFPIY 2756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CEP290	XP_011537058.1	SMC_prok_B	843..1562	CDD:274008	630/718 (88%)
		SMC_prok_B	1369..2176	CDD:274008	718/806 (89%)
		CEP209_CC5	1576..1703	CDD:293182	117/126 (93%)
		Smc	1927..2683	CDD:224117	630/755 (83%)
		DUF342	<2067..2151	CDD:302792	72/83 (87%)
Cep290	XP_006513589.1	Smc	<112..461	CDD:224117	310/355 (87%)
		PRK05771	429..>557	CDD:235600	115/127 (91%)
		SMC_prok_B	<846..1553	CDD:274008	624/706 (88%)
		SMC_prok_B	1360..2135	CDD:274008	693/774 (90%)
		CEP209_CC5	1567..1694	CDD:374641	117/126 (93%)
		Smc	1918..2677	CDD:224117	632/761 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83961016
Domainoid	1	1.000	2197	1.000	Domainoid score	I241
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77213
Inparanoid	1	1.050	4156	1.000	Inparanoid score	I239
Isobase	1	0.950	-	0	Normalized mean entropy	S6647
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51850
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009103
OrthoInspector	1	1.000	-	-		oto119580
orthoMCL	1	0.900	-	-		OOG6_106783
Panther	1	1.100	-	-	LDO	PTHR18879
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5961
SonicParanoid	1	1.000	-	-		X8325
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.380