DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO19 and myo19

DIOPT Version :9

Sequence 1:	XP_011523588.1	Gene:	MYO19 / 80179	HGNCID:	26234	Length:	1047	Species:	Homo sapiens
Sequence 2:	NP_001122117.1	Gene:	myo19 / 734140	XenbaseID:	XB-GENE-999897	Length:	969	Species:	Xenopus tropicalis

Alignment Length:	1047	Identity:	565/1047 - (53%)
Similarity:	705/1047 - (67%)	Gaps:	117/1047 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     8 HNPGSDGQAREYLREDLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQARYMADTFYTNAGCTL 72
            :|..::.:......|:::.||..|..|:..||||:|||||..|||:||||||.|..||||||||:
Frog    16 NNLSNNNKLNNSFEEEVKAFLIDEKQLHLYDDLTKVNPVTTATVLKCLQARYSAGVFYTNAGCTV 80

Human    73 VALNPFKPVPQLYSPELMREYHAAPQPQQCGHSESASATACPIGAGRILNHEELTTGQKKLKPHV 137
            ||:|||:||.:|||.|:|:|||||..||.|                               |||:
Frog    81 VAVNPFRPVCKLYSSEVMKEYHAASNPQGC-------------------------------KPHI 114

Human   138 FTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKFYAVVATSPASWESHKIAERIEQR 202
            |||.||.|:||:|.|:||||||:|||||||||||||||||||||.|:.| ..:.::::.||||.|
Frog   115 FTVAEQAYKNVQSQIQPVNQSIIVSGESGAGKTWTSRCLMKFYATVSAS-RCYITNEMVERIESR 178

Human   203 ILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRVACQASSERNFH 267
            :|:||||||||||||||||:|||||||:|||||||.||:|||::|||||||||||.||..|||||
Frog   179 VLDSNPVMEAFGNACTLRNHNSSRFGKYIQLQLNRTQQITGASIQTYLLEKTRVAHQAPLERNFH 243

Human   268 IFYQICKGASEDERLQWHLPEGAAFSWLPNPERSLEEDCFEVTREAMLHLGIDTPTQNNIFKTAP 332
            ||||:.||||..||.:|:|||.|.||||||.|.:||||.||||::||||||||..|||||||
Frog   244 IFYQVVKGASRHEREEWNLPEKANFSWLPNYENNLEEDDFEVTKDAMLHLGIDQTTQNNIFK--- 305

Human   333 EQQEGIDRMAWQSRKGGHFREVAMQWKVTLTSRWGLLRHCQVLAGLLHLGNIQFAASEDEAQPCQ 397
                                                     :|:||||||||||:.|.||:|||:
Frog   306 -----------------------------------------ILSGLLHLGNIQFSDSVDESQPCE 329

Human   398 PMDDAKCEDSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYA 462
            |::  ..::....|||||.:|...|||.:.||||.||: ||||:|||.::|||||||||||.|||
Frog   330 PLN--YTQEFASVAASLLKIPVSHLLERLSIRTITAGK-QQVFKKPCRKSECDTRRDCLAKTIYA 391

Human   463 RLFDWLVSVINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQ 527
            |||:|||:|||.:|||:...|..||||||||||||||:|:||||||||||||||||||:|||::|
Frog   392 RLFEWLVTVINENICAEAYRWNNFIGLLDVYGFESFPENNLEQLCINYANEKLQQHFVSHYLKSQ 456

Human   528 QEEYAVEGLEWSFINYQDNQPCLDLIEGSPISICSLINEECRLNRPSSAAQLQTRIETALAGSPC 592
            |:|||.||||||||:|||||.|:||||||||||.||:||||||||.|.|.|||:|:|.||:.:..
Frog   457 QDEYAAEGLEWSFISYQDNQSCVDLIEGSPISIFSLLNEECRLNRSSDAGQLQSRLEKALSHNKS 521

Human   593 LGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQQSQDPLLMGLFPTNPKEKTQ 657
            :|.:|.|::|:|||.||||.|:|....:.||||||:||||.:|||:|.|.||..|||....:...
Frog   522 IGRDKFSKKPNFIVSHYAGKVQYQIEDMAEKNKDPVPPELIQLLQESDDHLLQILFPVENNKPVY 586

Human   658 EEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLEACGL 722
            ...  .:||..:|||||||.|||.|:|:|||||||||||||||...||..|.|||||.||||||:
Frog   587 GAT--NNRAVGVTVVSKFKGSLESLMQILHSTTPHYIRCIKPNVDCQALVFRQEEVLMQLEACGI 649

Human   723 VETIHISAAGFPIRVSHRNFVERYKLL--RRLHPCTSSGPDSPYPAKGLPEWCPHSEEAT--LEP 783
            ||||:|||||||||:|..:|||||.::  |::| ..::..|..:..|      ....|.|  |..
Frog   650 VETINISAAGFPIRISFESFVERYSVIAPRQIH-MENNFNDCLFLKK------KQGFEKTDQLPS 707

Human   784 LIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQGG 848
            .:|.|||.  ||::   :..||..:... :|||.||||:|..|:||||..|...:...|.|||..
Frog   708 KLQTILHA--VLSK---LCKDSTLSNTL-VHCGTTKVFLTHLMVELLEERRLEAICSKAVCIQCC 766

Human   849 WRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELD--- 910
            |||:|.|:..:|.||...||||::.|||:|:|:|:|.|||||||.|:||:.:|..|||.|||
Frog   767 WRRYRQRKLAKQNRAATTIQAAVKGWLTKKYIERMHNAATVIKRIWKKWKEKMEALAAAELDDSI 831

Human   911 -GVEEKHFSQAPCS-LST--SP---LQTRLL--EAIIRLWPLGLVLANT------AMGVGSFQRK 960
             .||.......|.| :.|  ||   ||.:||  .||::...|||||...      .:.....:|.
Frog   832 EDVERTLLLSVPASPVKTLESPKTNLQDKLLTHSAILKFGTLGLVLYKAPAIRKYIVETDELKRN 896

Human   961 LVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRYADICPEPSPYSITGF 1025
            ..:..||.:...: :.|.|....::.|:|||||.|||||:||.::|||.:|:|||......|:||
Frog   897 QNILMCLNVLHRN-NRYKVTANCEEPGITSIRARPQGSIRFHYKRSPLHFANICPGKISCGISGF 960

Human  1026 NQILLER 1032
            |:||||:
Frog   961 NEILLEK 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO19	XP_011523588.1	MYSc_Myo19	49..823	CDD:276846	452/777 (58%)
myo19	NP_001122117.1	MYSc	45..752	CDD:214580	467/800 (58%)
myo19	NP_001122117.1	MYSc_Myo19	57..741	CDD:276846	452/777 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	890	1.000	Domainoid score	I921
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49819
Inparanoid	1	1.050	1052	1.000	Inparanoid score	I2839
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51417
OrthoDB	1	1.010	-	-		D106855at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		oto150089
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8679
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080