Protein Alignment CCDC170 and RUD3

DIOPT Version :9

• Sequence 1: XP_011534449.1
• Gene: CCDC170 / 80129
• HGNCID: 21177
• Length: 721
• Species: Homo sapiens
• Sequence 2: NP_014859.3
• Gene: RUD3 / 854391
• SGDID: S000005742
• Length: 484
• Species: Saccharomyces cerevisiae
• Alignment Length: 569
• Identity: 128/569 - (22%)
• Similarity: 225/569 - (39%)
• Gaps: 171/569 - (30%)

Human   162 ENKKQVSKNCRKH-------------EEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKE-NEF 212
            :|||:..|..:.|             ||.:..:...:.|....|..:| .::....|..|: :|.
Yeast     3 KNKKKTGKKAKSHPHVEDVDETVNKPEEIINSVNVTVPPKMSTDPEAD-GIVASPDDEGKDLSEG 66

Human   213 VKGQIV---ILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKE 274
            |..|.|   :..:|||  .:|.|.:.:.:..|..|:.| .|...|..:::|..|:|.      |.
Yeast    67 VDKQKVNDGLTVDTIN--PLEDKKAGDEMKELREEIER-LKLELSHKKDQETPNEDF------KN 122

Human   275 ALEREVKIFQERLLAGQQVWDASK-QEVSLLKKSSS---------ELEKSLKASQDAVTTSQSQY 329
            .|...:|   ||        |..| |..:||.|.||         |.:|.|:..|:.:|..:||.
Yeast   123 ELANVIK---ER--------DEFKTQYDTLLSKISSMKSIFNKMKEAQKQLEEVQEQLTEYESQN 176

Human   330 FSFREKIAALL--RGRLSMTGSTEDTILEKI-REMDSREE---SRDRMVSQLEAQISELVEQLGK 388
            ...::|:.|..  ...|..|..|.:|.||.: :|.:|.||   ..:..:..||.:..:::|:..|
Yeast   177 LKLKKKLEATKTENSELQSTIVTLNTELENLEKEQESTEEVFLEYESRIEALEDEKHDIIEKHSK 241

Human   389 ESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQ 453
            |...::|.                               :|.||.:.|:.:..|:...|.:.
Yeast   242 ELNTYRKE-------------------------------KDQLNLQVQELMIILENNKQDIS--- 272

Human   454 MAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIA 518
                   |:|.:    |.|....|||:.  :.|.:..|....|:.:.|.:::|
Yeast   273 -------DLRTE----RDELRQALESHE--KEKAVLKNSLNDLELKIEEVDNK------------ 312

Human   519 QLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQT 583
               .|::||     |||          ::|:.|:.:|:|..:.|.                 ..|
Yeast   313 ---REEEAR-----ERD----------QEVKSLRSQLDTEIETHN-----------------NDT 342

Human   584 KAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMI--EVVTSEMKTLKKSL 646
            :|:|.:.|   |||.|||.|.   |..|.|.::.:|..:..|.|...:|  |.:|..:..||||
Yeast   343 EALESMKK---QLEAMKEDAS---MKEKYEEESKQHILQIGKLRHEAIILNEHLTKALAMLKKS- 400

Human   647 EEAEKREKQLADFREVVSQMLGLNVTSLALP-----DYEIIKCLERLVH 690
            .::|..:|      |::|.:|   ::.:::|     .:|:::.|...::
Yeast   401 SDSESVDK------ELISNLL---ISFVSIPRADPRKFEVLELLSNFLN 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCDC170	XP_011534449.1	Smc	<49..>656	CDD:224117	122/528 (23%)
		TOP4c	<447..576	CDD:238111	24/128 (19%)
RUD3	NP_014859.3	SMC_prok_A	88..>382	CDD:274009	92/411 (22%)
		GRAB	401..449	CDD:402134	8/49 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000