Protein Alignment MAP3K19 and STE11

DIOPT Version :10

• Sequence 1: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Sequence 2: NP_013466.1
• Gene: STE11 / 851076
• SGDID: S000004354
• Length: 717
• Species: Saccharomyces cerevisiae
• Alignment Length: 779
• Identity: 204/779 - (26%)
• Similarity: 335/779 - (43%)
• Gaps: 182/779 - (23%)

Human   660 DLKYSDMF-KEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNK---CRS 720
            ||.:..:| :||..|       :...:.:.|:: .||.:.....::|..|....:|.::   .|.
Yeast    21 DLPFVQLFLEEIGCT-------QYLDSFIQCNL-VTEEEIKYLDKDILIALGVNKIGDRLKILRK 77

Human   721 SHS----------ERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVL-ISKEKSSKAVHSNLHDIE 774
            |.|          .|..|:..::|...|......:.. |.::|.|: |..:.|:|.|  |::...
Yeast    78 SKSFQRDKRIEQVNRLKNLMEKVSSLSTATLSMNSEL-IPEKHCVIFILNDGSAKKV--NVNGCF 139

Human   775 NGDGISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPE---QSMKQNEFPPVSDLSI---------V 827
            |.|.|.:.  .|:...:|.|::........:.|..:   ....:|....:.|:.:         |
Yeast   140 NADSIKKR--LIRRLPHELLATNSNGEVTKMVQDYDVFVLDYTKNVLHLLYDVELVTICHANDRV 202

Human   828 EE-----VSMEESTGDRDISNNQILTTSLRDLQELEELHHQIPFIPSEDSWAVPSEKNSNKYVQQ 887
            |:     ||.:::..|:.||.::.|  .||.|..|.::.              ||..|   .:.|
Yeast   203 EKNRLIFVSKDQTPSDKAISTSKKL--YLRTLSALSQVG--------------PSSSN---LLAQ 248

Human   888 EKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANK 952
            .|    .:|..||...|..|   ::..|..:.:  |:.:...|..|:....|:.|
Yeast   249 NK----GISHNNAEGKLRID---NTEKDRIRQI--FNQRPPSEFISTNLAGYFPH---------- 294

Human   953 SITYQMFGKTL------SGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANE 1011
             ...:...||:      |...||:|....|..:..:.|.||                   |.:|.
Yeast   295 -TDMKRLQKTMRESFRHSARLSIAQRRPLSAESNNIGDILL-------------------KHSNA 339

Human  1012 TDPENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEE-- 1074
            .|    ..:|:....|......:|||:....|..      .|:...|||:.::.|..|.:.|:
Yeast   340 VD----MALLQGLDQTRLSSKLDTTKIPKLAHKR------PEDNDAISNQLELLSVESGEEEDHD 394

Human  1075 -----------------PILWTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVAL----------- 1110
                             |..|.||..:|.|::|:||.|:.:. |:|:|||||.:
Yeast   395 FFGEDSDIVSLPTKIATPKNWLKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDN 459

Human  1111 ------DTSNKLAAEKE-----------------YRK----LQEEVDLLKALKHVNIVAYLGTCL 1148
                  |.:|:...::|                 :||    ||.|::|||.|.|.|||.|.|...
Yeast   460 NKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQ 524

Human  1149 QENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMP 1213
            :...::||:|:|||||:||::|.:||..|.:...:|:|||.||||||:..::||||||.|:::..
Yeast   525 EGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDI 589

Human  1214 TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMA 1278
            .|.:|:.|||.:::|  :.|| ...:...|:.|:.:||:|||:.::....|:||||.||.|.||.
Yeast   590 KGCVKITDFGISKKL--SPLN-KKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMF 651

Human  1279 TGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 1342
            |||.|.....:|.|:|.||.:  ..|.:|...:....:|:|.....|...|||||:||:|.:|:
Yeast   652 TGKHPFPDFSQMQAIFKIGTN--TTPEIPSWATSEGKNFLRKAFELDYQYRPSALELLQHPWLD 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	112/303 (37%)
STE11	NP_013466.1	SAM_Ste11_fungal	20..82	CDD:188933	15/68 (22%)
		Ras_bdg_2	121..224	CDD:434263	22/106 (21%)
		Protein Kinases, catalytic domain	415..712	CDD:473864	112/301 (37%)