Protein Alignment MAP3K19 and map3k19

DIOPT Version :10

• Sequence 1: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Sequence 2: XP_068079701.1
• Gene: map3k19 / 572217
• ZFINID: ZDB-GENE-081104-140
• Length: 1236
• Species: Danio rerio
• Alignment Length: 1490
• Identity: 437/1490 - (29%)
• Similarity: 647/1490 - (43%)
• Gaps: 467/1490 - (31%)

Human    11 SFCRTGLVG-KDRLKERHAESLLDICHDTNSSPTDLMTVTKN-QNIILQSISRSEEFDQD----- 68
            |.|..||.. ...|.||.|::.|  |:  ||:.|.|.....: |..:|.:::|.::....
Zfish    49 SACSRGLTRVMHFLLERGADATL--CN--NSNQTALHVCRPSLQEELLMTMTRPDQRQLSLAAWR 109

Human    69 GD-CSHSTLVNEEEDPSGGRQDWQPRT------------EGVEITVTFPRDVSPPQEMSQ----- 115
            || |....|:.:.:.....:|:....|            ||:.:    |.|..|.:.:.:
Zfish   110 GDLCCLQDLMGQTDMHDLNKQNRDGLTPLMLAVRDVDLFEGLAL----PWDYQPVEVVKKLMSLT 170

Human   116 EDLKEKNLINSSLQEWAQAHAVSHPNE---------IETV-ELRKKK---LTMRPLVLQKEESSR 167
            .|:|..:. |.....|..:|..|...|         ::|| ::.|::   :|:      .|.|..
Zfish   171 ADMKILDQ-NGHTALWYISHLKSTKREELFAILDSSMQTVSDVMKRESADITI------AEMSHT 228

Human   168 ELCNVNLGFLLPRSCLELNISKSV-TREDAPHFLKEQQRKSEEFSTSHMKYSGR----SIKFLLP 227
            ::|..|      |.||:..:...: .|:|.    |:::::|...|:....::||    ..:.|.|
Zfish   229 DICEDN------RICLDDYMEPKIDIRQDG----KDERKRSSRTSSLPSLWNGRKDWGKTRHLHP 283

Human   228 PLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKS---L 289
            .|:|                   ...:||:|.:               :|.|:    |.||   |
Zfish   284 LLAL-------------------SSSSIPALPA---------------APVNQ----LSKSAPIL 310

Human   290 MDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWKSKEIE-ECNKIE------ITHFEKGQSL 347
            |:|.|. ::|.:.:|     ....:..:.:|..|:.|.|..: .|::..      .:.:....:|
Zfish   311 MNPLLH-ANGLLQAR-----ANIQNRLRGVETGEDEKQKIPQTPCSRTPNHIAPLDSRYTDNSAL 369

Human   348 VSFEN---LKEGNIPAV------REEDIDCHGSKTRK--PEEENSQYLSSRKNESSVAKNYEQDP 401
            .|||:   .|:.:|..|      |.|.|....|:..:  .||.||...||::.:.:|       |
Zfish   370 SSFEHPLLFKQTSILPVLSQSRRRLEKISRQSSRRSRAGSEESNSCSSSSQEEDEAV-------P 427

Human   402 EIV-----------------CTIPSKFQETQHSEITPSQDEEMRN------------------NK 431
            :|.                 |.   .||:...|.|..|..::|:.                  :|
Zfish   428 QITQRRHVSLGKSMSFKLGNCL---DFQDLVSSVINISISDKMKGCIKPPIATEFEDKMKCKPSK 489

Human   432 AASKRVS--------LHKNEAMEPNNILEE-------CTVLKSLSSVVFDDPIDKLPEGCSSMET 481
            |..|.:.        .|.:||  |.||:.|       |..|....::                 .
Zfish   490 APEKDLQEKSPPMDCCHVSEA--PRNIVRELQPTAKRCHFLAGEKNI-----------------A 535

Human   482 NIKISIAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKH 546
            |:.:...|:...|.::.|.:|                |.|.:..|.:|..|.|.|:..|:.....
Zfish   536 NLDMDTEEKYTHEKNKPVKMI----------------KRSERKGKTSIQTNQSFNVLAHRNQSTG 584

Human   547 KMNSHR--SKLDSKTKTSKKTPQNFVI-------------STEGPIKPTMHKTSIKTQIFPALGL 596
            |::|:|  |...||.:.....|.:..|             :.||   ||..:.|
Zfish   585 KISSNRINSPTQSKVQLRGNKPTSLAIGETTNKYVTCKKNADEG---PTPRRVS----------- 635

Human   597 VDPRPWQ--LPRFQKKMPQIAKKQSTHRTQK----PKKQSFPCICKNPGTQKSCVPLS--VQPTE 653
               .|:|  :...||::         ||..|    |||                 |::  .|...
Zfish   636 ---EPFQHVVSNDQKQL---------HRDLKSARAPKK-----------------PVTGPAQRAR 671

Human   654 PRLNYLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKC 718
            ..::|  ..|:|||.:|.....||.|||||.||:|.::|
Zfish   672 SAVDY--ATYNDMFLKIGQGDEGPAIYEMFATPLYENLR-------------------------- 708

Human   719 RSSHSERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEK--SSKAVHSNLHDIENGDGISE 781
            ..|.:|||..|.|.|..|:      :.|..:|.:..|.:::.|  |.::.......:::.|.::
Zfish   709 ADSSAERKRQIHTPLQVKR------QISGKLKGQKTVDVNRRKKTSERSSRVKCRQLKHRDNLN- 766

Human   782 PDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPP-------------VSDLSIVEEVSME 833
                 |::......|:.:.|.:..:.:.....|:.|.|.             .|.||::|||
Zfish   767 -----KATKKHLPPSECKCHVLVTSASETSQRKKFERPEGEGKDISSVERQCTSILSVIEEV--- 823

Human   834 ESTGDRDISNNQILTTSLRDLQELEELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKV 898
                   :||    |.|..:|  ::.:.||      |.:   |.:.|:|:     :.....::::
Zfish   824 -------LSN----TASKANL--IKNIIHQ------EQT---PLKANANR-----EPEVLCVTRL 861

Human   899 NASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTL 963
            .|..::..                                 |                     |.
Zfish   862 PAQPLINT---------------------------------W---------------------TS 872

Human   964 SGTNS-ISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPE-NLNLVLRWRGS 1026
            .||.| :.|..::.|.:..|||:||..||.|||.|:.:|..:. |..||...| |.:|
Zfish   873 DGTASPVYQRFLEGVGDGPLTDDLLRSLAEELLLLERRDIETL-KTENEDGTEFNRDL------- 929

Human  1027 TPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGT 1091
                    .:|.||.::..            :|:.|..::..|. |.:.|.|||||:||||||||
Zfish   930 --------HSKFKILQNEG------------VSSGKLHYTFGSC-SGDAITWTKGEVLGKGAYGT 973

Human  1092 VYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIF 1156
            ||||||||||||||||||||.|....|||||.:|:.||||||.|||.|||.:|||.|.||.||||
Zfish   974 VYCGLTSQGQLIAVKQVALDASTSEIAEKEYDRLEREVDLLKNLKHTNIVGFLGTALSENIVSIF 1038

Human  1157 MEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLID 1221
            ||::||||||:|:.:||||||.||..|::|||:||||||.|.|:|||:||||:||||||::||||
Zfish  1039 MEYIPGGSISNILGQFGPLPEKVFVLYSQQILEGVAYLHANRVIHRDLKGNNIMLMPTGVVKLID 1103

Human  1222 FGCARRLAWAGLN-GTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLA 1285
            |||||||:....: |:..|:|||:||||||||||||||:|:||||||||||||||||||||||||
Zfish  1104 FGCARRLSCLQTSTGSKGDLLKSVHGTPYWMAPEVINETGHGRKSDIWSIGCTVFEMATGKPPLA 1168

Human  1286 SMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERSH 1345
            .|::|||::||||.|||||.|.|.||.:|.|||:.||||||.:||||.:||:|.|:  ||
Zfish  1169 HMNKMAALYYIGARRGLMPSLSDDFSTDAKDFVQACLTRDQRQRPSAEELLRHPFI--SH 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	194/265 (73%)
map3k19	XP_068079701.1	ANKYR	<18..199	CDD:440430	35/158 (22%)
		ANK repeat	43..73	CDD:293786	9/25 (36%)
		ANK repeat	75..131	CDD:293786	10/55 (18%)
		ANK repeat	133..177	CDD:293786	8/47 (17%)
		STKc_YSK4	958..1224	CDD:270801	194/265 (73%)