Protein Alignment MAP3K19 and Pak3

DIOPT Version :10

• Sequence 1: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Sequence 2: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 147/580 - (25%)
• Similarity: 233/580 - (40%)
• Gaps: 134/580 - (23%)

Human   830 VSMEESTGDRD--------ISNNQILTTSLRDLQEL--EELHHQIPFIPSEDSWAVPSEKNSNKY 884
            ||..:.|||.:        :.|:||    .||.|:.  :..:|.:.:.               .|
  Fly    32 VSRNQETGDLEGLPAPWVRLMNSQI----TRDEQDKNPDAAYHAVKYY---------------NY 77

Human   885 VQQEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNF-SFQAKQESASSQTYQYWVHYLDHDS 948
            ..::|:|..      ....:|.|:    :.:.||.:.|: :::.|.:|...:.       .|.|.
  Fly    78 SIKKKENEV------FKPFITEDV----IHEESKEIENYVNYKNKHKSQDPEK-------SDDDG 125

Human   949 LANKSITYQMFGKTLSGTNSISQEIMDSVNN--------EELTDELLGCL--AAELLALDEKDNN 1003
            .:..:.|....|...|..||.|..|.||...        ||:..||...|  ...|.|..::...
  Fly   126 SSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPP 190

Human  1004 SCQKMANETDPENLNLVLRWRGSTPKEMGRETTKV--KIQRHSSGLRIYDREEKFLISNEKKIF- 1065
            ...|.:..|.|             ||...:...:|  |..|.|...|..|.:.:..|:.:..|.
  Fly   191 VPPKKSPHTIP-------------PKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTIIIK 242

Human  1066 --------------SENSLK--SEEPILWTKGEI----------------------LGKGAYGTV 1092
                          .|..|:  .|:....|..||                      :||||.|.|
  Fly   243 PAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIV 307

Human  1093 YCGLTSQGQ-LIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCL--QENTVS 1154
            :.....|.: .:|||  .:|..|:.:.:    .:..|:.:||...|.|:|.:|...|  .|:.:.
  Fly   308 FIAADLQNESQVAVK--TIDMKNQSSKD----LILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLW 366

Human  1155 IFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKL 1219
            :.||::.||.::.::.........:.| ..::.|..:::||...::|||||.:||:|...|.:|:
  Fly   367 VVMEYMDGGPLTDVVTETVMKERQIAC-VCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKV 430

Human  1220 IDFG-CARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPP 1283
            .||| ||        |....:..::|.||||||||||:....||:|.||||||....||..|:||
  Fly   431 TDFGFCA--------NIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPP 487

Human  1284 LASMDRMAAMFYIGAHRGLMPPLP--DHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 1341
            ......:.|::.|.|:.  .|.:.  |..|.|..||:..||..:...|.:|.:||.|.||
  Fly   488 YLYETPLRALYLIAANG--RPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	89/292 (30%)
Pak3	NP_001262638.1	PBD	19..76	CDD:395634	12/62 (19%)
		Protein Kinases, catalytic domain	288..545	CDD:473864	86/273 (32%)