Protein Alignment MAP3K19 and drl-1

DIOPT Version :10

• Sequence 1: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Sequence 2: NP_001023134.2
• Gene: drl-1 / 3565236
• WormBaseID: WBGene00017578
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 236
• Identity: 55/236 - (23%)
• Similarity: 93/236 - (39%)
• Gaps: 35/236 - (14%)

Human  1121 EYRKLQEEVDLLKALKHVNIVAYLGTCLQ-ENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYT 1184
            |..|:...::.|..|:|..:....|...: |..:.:|...||.|:::.:: :...:|:....:|.
 Worm   149 EIEKISRTIEDLCQLRHKRLAPMYGYHWRLETELMVFRAHVPSGTVADLV-KVSAIPQETAVRYI 212

Human  1185 KQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLID---FGCARRLAWAGLNGTHSDMLKSMHG 1246
            ..::..:|||||...||..:..:|::|..:..|.|.|   .|.........|..:..:..:|:..
 Worm   213 VHVIDALAYLHERKHVHGKLNASNLLLTISNDILLADPFIEGLPSAQKRRALLASPPEAFRSLES 277

Human  1247 TPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIG--AHRGLM------ 1303
            .| .:.|          .|||||:||.:..|.|..||...    ..|.:.|  .||.|:
 Worm   278 YP-CLTP----------SSDIWSVGCVLVTMLTRYPPFLE----HYMHFHGESLHRELVSEWCTR 327

Human  1304 -------PPLPDHFSENAADFVRMCLTRDQHERPSALQLLK 1337
                   ..|....|:...:.:......|...||||..||:
 Worm   328 RQLIYSSQTLIPSASKEICELIDQIFNVDPENRPSAQNLLE 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	55/236 (23%)
drl-1	NP_001023134.2	Protein Kinases, catalytic domain	143..368	CDD:473864	54/234 (23%)