Protein Alignment MAP3K19 and Map3k19

DIOPT Version :10

• Sequence 1: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Sequence 2: XP_038947212.1
• Gene: Map3k19 / 289001
• RGDID: 1566400
• Length: 1513
• Species: Rattus norvegicus
• Alignment Length: 1331
• Identity: 764/1331 - (57%)
• Similarity: 931/1331 - (69%)
• Gaps: 41/1331 - (3%)

Human    25 ERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSI--SRSEEFDQDGDCSHSTLVNEEEDPSGGR 87
            ||||||||||||:..|:|.| |||:|.:||.||||  |.||:|..|.|.|.|.|..|...|.|
  Rat   212 ERHAESLLDICHEAGSTPMD-MTVSKTENITLQSISSSSSEDFALDDDFSPSILAGEGTAPRG-- 273

Human    88 QDWQPRTEGVEITVT-FPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVELRKK 151
            :.|..|||||||.|| ||.|  .|||.|||||.|.:.:.|...||...|.||...|:|.|.|..:
  Rat   274 EGWPRRTEGVEILVTMFPPD--SPQEASQEDLTESSQVTSERPEWGPGHPVSPAKEVEMVGLTSR 336

Human   152 KLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMK 216
            .||.:|.:|:.|..|:|||..::....||.||:.:.:.:..||:|||.||.|.|||::|.||.|:
  Rat   337 MLTTQPSLLKTEGGSQELCGADVALSPPRPCLDPSTAIAAVREEAPHVLKVQPRKSDKFPTSDMR 401

Human   217 YSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPK----LSVSVRQSDELSP 277
            ||.|..:..|||.||||.||.|..:.::.|||:..||.:|||:..|||    ||..:.||.|.|.
  Rat   402 YSSRRTELPLPPPSLLPMRSSVFNMEKSPKFPRHGERKVPSLSLSVPKLLEPLSQPLSQSAEFSS 466

Human   278 SNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWKSKEIEECNKIEITHFE 342
            :........:...:.|||.||..|||||:|||.|:...|..   .|:|:|:|.:..:|.|.:.||
  Rat   467 AKNQQEVTWEGPPEHTLRGSDWAIWSRNLCSFRKSRKQRGV---AESWRSQETKGGDKTETSGFE 528

Human   343 KGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPEEENSQYLSSRKNESSVAKNYEQDPEIVCTI 407
            :|..|.|..::||...|..||.|..||.|:.  ...|:||||.|.:.||...:..|:|.|:....
  Rat   529 EGPFLFSCGSVKEDTAPIERERDSGCHISEI--SGREDSQYLLSGEKESWTDRAVEKDLEVEHPF 591

Human   408 PSKFQETQHSEITPSQDEEMRNNKAA-SKRVSLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDK 471
            .|:..|..:::||.::::|:.|.|.. |:..|:|:...::|:.:|||.:|.|::..:..|.||..
  Rat   592 LSELLEASNTKITLAEEKEIGNEKVPDSESNSVHRAGTVQPHAVLEELSVPKNIPRMNSDGPITG 656

Human   472 LPEGCSSMETNIKISIAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVN 536
            |.||....|.|.|:.|.|...|||:..|||:|||||.:|:||.|..|||:||.||..:.::.|.|
  Rat   657 LLEGHGDTEENRKLPIEEETNPEMNGAVPLVHITFPGEGTPKGPARAKPNLQRRKHPVQSSGSPN 721

Human   537 IPVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRP 601
            |...||:.|.:.|:||      ||...:.|.|.::|.:..|||.:.|.|||||:||||..:|.||
  Rat   722 ILARQEHGKLQTNTHR------TKARNRPPPNLMVSIQASIKPNVRKNSIKTQVFPALEFMDHRP 780

Human   602 WQLPRFQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDM 666
            ....:||::.| :.:|:|..:|||||||:||.||||.|.:|..|.|||:.|:|||::||||||||
  Rat   781 HPPSKFQRRAP-VTEKKSMCQTQKPKKQAFPHICKNAGIKKPGVVLSVETTDPRLHFLDLKYSDM 844

Human   667 FKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRT 731
            ||||||.:||||||||||||||.|:||.||.|:.:|.|||:|||||.:.|||:.|.|:|.:|.|.
  Rat   845 FKEINSASNGPGIYEMFGTPVYSHIREAERHEHRHYHEICAAPSGRSVGNKCQPSQSDRCANSRA 909

Human   732 RLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSS 796
            ||.||:.|:|.||.|.|:||:|:.||||:|..|.:..::.     |.:|||.||.:.|.|:.|||
  Rat   910 RLLQKRPHVKPPKPSLGLKQKHRGLISKDKGCKGMGGHVE-----DSVSEPGWQTRPSANDSLSS 969

Human   797 KDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQELEELH 861
            |||....:|...||.|.:|.|.||:||||||||:..||...:..|.:|..||.||.||:.||.||
  Rat   970 KDEAQLTHLTLIPETSPEQRETPPLSDLSIVEEIFTEECADEEGILHNDSLTQSLGDLKALEGLH 1034

Human   862 HQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNF--- 923
            .|.|.:||||||||.|||:|.|:|...|.:...|.|:||.::.|..|||||:||.|||..:|
  Rat  1035 PQTPLVPSEDSWAVLSEKHSGKHVSPGKHDVGPLDKINADQMFTGYLEFDSLSDKSKTRVSFSRY 1099

Human   924 SFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLG 988
            |||.|.|||.|.|.|.|.|.||.|||.:.|.|||.|||       :||.|:|...||||||||||
  Rat  1100 SFQEKPESAPSPTEQPWAHSLDQDSLEDDSTTYQRFGK-------VSQGILDPGKNEELTDELLG 1157

Human   989 CLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDRE 1053
            ||..||||:||||||||:.|.||.|..:||||...||:|.:.:.||||.||:||..:|.:||| |
  Rat  1158 CLVEELLAIDEKDNNSCRIMTNEADTRDLNLVFGRRGNTIEGLDRETTDVKLQRCINGFQIYD-E 1221

Human  1054 EKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAA 1118
            |.||.|.|::..|:||||.||.|.||||||||:||||||||||||.||||||||||||:::|||.
  Rat  1222 ENFLTSYEERTLSDNSLKHEEAIFWTKGEILGRGAYGTVYCGLTSLGQLIAVKQVALDSTDKLAT 1286

Human  1119 EKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKY 1183
            ||||||||||||||||||||||||||||||:|||:||||||||||||||||||||||||.|||||
  Rat  1287 EKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPETVFCKY 1351

Human  1184 TKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTP 1248
            |:||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||.|||
  Rat  1352 TRQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTP 1416

Human  1249 YWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSEN 1313
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.
  Rat  1417 YWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDRFSEP 1481

Human  1314 AADFVRMCLTRDQHERPSALQLLKHSFLERS 1344
            ||||||:||||||||||||||||.|:|:.||
  Rat  1482 AADFVRLCLTRDQHERPSALQLLTHAFMLRS 1512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	246/264 (93%)
Map3k19	XP_038947212.1	ANKYR	<44..226	CDD:440430	12/13 (92%)
		ANK repeat	44..74	CDD:293786
		ANK repeat	76..133	CDD:293786
		ANK repeat	135..179	CDD:293786
		STKc_YSK4	1244..1509	CDD:270801	246/264 (93%)