Protein Alignment MAP3K19 and byr2

DIOPT Version :10

• Sequence 1: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Sequence 2: NP_595714.2
• Gene: byr2 / 2540612
• PomBaseID: SPBC1D7.05
• Length: 659
• Species: Schizosaccharomyces pombe
• Alignment Length: 646
• Identity: 177/646 - (27%)
• Similarity: 295/646 - (45%)
• Gaps: 131/646 - (20%)

Human   788 SSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVE---EVSMEESTGD----------- 838
            :.|.:||..:|.:               .|||....|..:.   :....:|.||
pombe    52 AKGKQFLKQRDYL---------------REFPRPCILRFIACNGQTRAVQSRGDYQKTLAIALKK 101

Human   839 ---RDISNNQI-LTTSLRDLQELEELHHQIPF------------IPSEDSWAVPSEKNSNKYVQQ 887
               .|.|...: ::.|.|.....||...||.|            :|.|.  ..||.::..:..:.
pombe   102 FSLEDASKFIVCVSQSSRIKLITEEEFKQICFNSSSPERDRLIIVPKEK--PCPSFEDLRRSWEI 164

Human   888 EKQNTASLSKVNA-----SRILTNDLEFDSV-SDHSKTLTNFSFQAKQESASSQTYQYWVHYLDH 946
            |....|:||..::     |.:|....:..|| |:::|...::. :...|..:|:...:   :.||
pombe   165 ELAQPAALSSQSSLSPKLSSVLPTSTQKRSVRSNNAKPFESYQ-RPPSELINSRISDF---FPDH 225

Human   947 -----DSLANKSITYQMFGKTLSGTN--SISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNS 1004
                 :...:.|:...:..:|..|.|  :..|||:...:......||: |..:.|.....:|.|.
pombe   226 QPKLLEKTISNSLRRNLSIRTSQGHNLGNFGQEILPRSSRRARPSELV-CPLSSLRISVAEDVNR 289

Human  1005 CQKMANETDPENLNLVLRWRGSTPKEMGRETTKVKIQ--RHSSGLRIYDREEKFLISNEKKIFSE 1067
            ..::....||. |.:....|.|.|..:.:..|.|.::  ..|:|      .||   |::..:|||
pombe   290 LPRIDRGFDPP-LTVSSTQRISRPPSLQKSITMVGVEPLYQSNG------NEK---SSKYNVFSE 344

Human  1068 ------------------------------------NSLK---SEEPILWTKGEILGKGAYGTVY 1093
                                                |:|:   .::.|.|.:|.::|.|::|.||
pombe   345 SAHGNHQVLSFSPGSSPSFIEQPSPISPTSTTSEDTNTLEEDTDDQSIKWIRGALIGSGSFGQVY 409

Human  1094 CGL-TSQGQLIAVKQVALDTSNKLAAEKEYRKLQE----EVDLLKALKHVNIVAYLGTCLQENTV 1153
            .|: .|.|:|:|||||.||:.::  ::..:.||.:    |:.||:.|.|.:||.|||:.|..:.:
pombe   410 LGMNASSGELMAVKQVILDSVSE--SKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHL 472

Human  1154 SIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIK 1218
            :||:|:|||||::.::..:|...|.:...:.||.|:|:.|||...:|||||||.|:::...|.||
pombe   473 NIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKIK 537

Human  1219 LIDFGCARRLAWAGLNGTHS---DMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATG 1280
            :.|||.:::|.   ||.|.:   ....|..|:.:||||||:.::.:..|:||||:||.|.||.|.
pombe   538 ISDFGISKKLE---LNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTS 599

Human  1281 KPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 1341
            |.|..:.|:|.|:|.||  ..::|..|.:.|.:|.||:......|.:.||:|.:||.|.|:
pombe   600 KHPYPNCDQMQAIFRIG--ENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHPFV 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	107/272 (39%)
byr2	NP_595714.2	SAM_2	1..65	CDD:429573	4/27 (15%)
		Protein Kinases, catalytic domain	393..658	CDD:473864	106/271 (39%)