Protein Alignment MAP3K19 and Map3k19

DIOPT Version :10

• Sequence 1: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Sequence 2: NP_035867.2
• Gene: Map3k19 / 22625
• MGIID: 1203481
• Length: 1515
• Species: Mus musculus
• Alignment Length: 1353
• Identity: 791/1353 - (58%)
• Similarity: 963/1353 - (71%)
• Gaps: 37/1353 - (2%)

Human     4 HWNFQVASFCRTGLVG--KDRL--KERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEE 64
            |:..|:.|:.:..|:.  .|.:  .||||||||||||:..|:|.: |||::.:|:.|||||.||:
Mouse   187 HYVSQIESWRKQQLLDILMDSMPRPERHAESLLDICHEAGSTPME-MTVSQTENLTLQSISSSED 250

Human    65 FDQDGDCSHSTLVNEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQ 129
            ||.:.|.|...|..|...|.|  ::|..|||||||.||||.|  |.||.|||||||.|.:.|..|
Mouse   251 FDLEDDFSPFILAREGAAPRG--ENWPRRTEGVEIIVTFPPD--PLQEASQEDLKESNQVTSEHQ 311

Human   130 EWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTRE 194
            |..|.|.||.|::.|.|.|..:.||.:|.:|:.:.||.|||.|::....||.||:.:::.|...|
Mouse   312 EREQVHPVSPPDDAEMVGLTGRMLTTQPSLLKTDGSSEELCGVDVALSPPRPCLDSSLAASAAGE 376

Human   195 DAPHFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLT 259
            .||..||||||:|:||.||.:.||.|.....|||||.||.||.:..:.::.|.|:.:||.:|||:
Mouse   377 VAPCVLKEQQRQSDEFPTSDISYSSRRTGLPLPPLSCLPMRSCIFNMEKSPKSPRHRERKVPSLS 441

Human   260 SFVPK----LSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLE 320
            ..|||    ||..:.||.|.|.|........:..::.|||.|:..:||||||||.|:......
Mouse   442 LSVPKLLEPLSRPLSQSAEFSSSKNHQEVTQEGPVEHTLRGSNCTLWSRNMCSFRKSGKQGVA-- 504

Human   321 KEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPEEENSQYLS 385
              |:|.|:|:|..:|.:.:.|::|.||.|.|::||...|..||.|...|.|:.::..|: |||||
Mouse   505 --ESWPSQEMEGWDKTKTSGFKEGPSLFSCESVKEDTTPTERERDSGYHVSEMQRGGED-SQYLS 566

Human   386 SRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRN-NKAASKRVSLHKNEAMEPNN 449
            |||.||..|:..|:|..:...|..|..|..:||:||::::|:.| |...:|..|:||:.||||:.
Mouse   567 SRKKESWTARVVERDSGVEHPILCKLLEVSNSEMTPAEEKEIGNENVPDAKSNSVHKSGAMEPHA 631

Human   450 ILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSRMVPLIHITFPVDGSPKE 514
            ..||.:|.|:..||..|.|.::| ||...:|.|.||.:.|...|||:.:|||.||.||.:|:.|.
Mouse   632 ASEEVSVPKNGPSVNSDGPAEEL-EGHRDIEQNRKIPMEEETNPEMNGVVPLTHIAFPGEGTSKG 695

Human   515 PVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKP 579
            |..|:|.||.||....|::|.|:..|:|:||.:.|:||:||||:||...:.|.|.::|.:..|||
Mouse   696 PARAEPHLQRRKRPAQNSNSFNLLAHREHDKLQTNTHRTKLDSRTKARNRAPPNLMVSIQASIKP 760

Human   580 TMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQKSC 644
            .|||.|||||:||||.|:|.||....:||::.| :.:|:|||:|||||||:||.|.|:.|.:|..
Mouse   761 NMHKNSIKTQVFPALELIDHRPHPSSKFQRRAP-LTEKKSTHQTQKPKKQAFPRIGKHAGIKKPG 824

Human   645 VPLSVQPTEPRLNYLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAP 709
            :|||.:.|:|||::||||||||||||||.:||||||||||||||||:||.||.::..||||.:||
Mouse   825 IPLSAETTDPRLHFLDLKYSDMFKEINSASNGPGIYEMFGTPVYCHIREAERHDHRCYREIRTAP 889

Human   710 SGRRITNKCRSSHSERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIE 774
            |||.:.|||:||.|:|.||.|.||.||:.|:|.||...|::|:|:..|||:|..|.:..:..
Mouse   890 SGRCVVNKCQSSESDRCSNSRARLLQKRQHIKPPKPLHGLRQKHRGFISKDKGCKDMGGHTE--- 951

Human   775 NGDGISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDR 839
              |.:||||.|:||.||:||||||:...|:|...||.|.:|....||||||||||:..||...:.
Mouse   952 --DSVSEPDGQMKSPGNDFLSSKDDAQLMHLIPIPELSPEQKAPAPVSDLSIVEEIFTEECADEE 1014

Human   840 DISNNQILTTSLRDLQELEELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRIL 904
            .|.|:..||.||.||:|.|.||.|.|.:|||:||||.|||.|.|.|..||.|...|.|:||.::.
Mouse  1015 GILNDDSLTQSLGDLKEPEGLHPQAPLVPSENSWAVLSEKRSGKRVSPEKHNVEPLDKINAEQMF 1079

Human   905 TNDLEFDSVSDHSKTLTNF---SFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGT 966
            ...|||||:|:.||||.:|   |||...|.|.|.|.|:|...|:.|||.|.|.|||.|||
Mouse  1080 PGYLEFDSLSEKSKTLVSFSSCSFQENLERAPSPTEQHWARSLEQDSLENNSTTYQTFGK----- 1139

Human   967 NSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEM 1031
              |||||:|...||||||||||||..||||||||||||||.|.||.|.:|||||...||:|.:|:
Mouse  1140 --ISQEILDPGKNEELTDELLGCLVEELLALDEKDNNSCQIMTNEADAKNLNLVFSRRGNTIEEL 1202

Human  1032 GRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGL 1096
            |||||.||:||..:|.|||| ||.||.|||||..|:.||..||.|.||||||||:||||||||||
Mouse  1203 GRETTDVKLQRCINGFRIYD-EENFLTSNEKKTLSDKSLNHEEAIFWTKGEILGRGAYGTVYCGL 1266

Human  1097 TSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVP 1161
            ||.||||||||||||||:|||.||||||||||||||||||||||||||||||:|||:||||||||
Mouse  1267 TSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVP 1331

Human  1162 GGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAR 1226
            |||||||||||||||||||||||:||||||||||:|||||||||||||||||||||||||||||:
Mouse  1332 GGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAK 1396

Human  1227 RLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 1291
            ||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1397 RLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 1461

Human  1292 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 1344
            ||||||||||||||||..|||.||||||:|||||||||||||||||||||:||
Mouse  1462 AMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFLKRS 1514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	249/264 (94%)
Map3k19	NP_035867.2	ANKYR	<44..226	CDD:440430	17/38 (45%)
		ANK repeat	44..74	CDD:293786
		ANK repeat	76..133	CDD:293786
		ANK repeat	135..179	CDD:293786
		STKc_YSK4	1246..1511	CDD:270801	249/264 (94%)