Protein Alignment MAP3K19 and map3k19

DIOPT Version :10

• Sequence 1: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Sequence 2: XP_002941471.3
• Gene: map3k19 / 100488738
• XenbaseID: XB-GENE-6046272
• Length: 1285
• Species: Xenopus tropicalis
• Alignment Length: 1336
• Identity: 389/1336 - (29%)
• Similarity: 580/1336 - (43%)
• Gaps: 374/1336 - (27%)

Human    29 ESLLDICHDTNSSPTDLMTVTKNQNII-LQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQDWQP 92
            |.:.|.|.||.....:..|....|.:. :||.|..:..:.:   .:|::...||||      |:.
 Frog   209 EPVCDFCPDTKLPLYNTSTAGGGQTLAHIQSCSPGQGINPN---RNSSIQVTEEDP------WEE 264

Human    93 RTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSH------------------ 139
            ..|           |..|.|::.          ||||   |||...|
 Frog   265 AAE-----------VPNPDEVTY----------SSLQ---QAHTTLHEMEGVDRAPDILKGSLAR 305

Human   140 -------PNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 197
                   ||:|..:....:..::.|..|:.:..:.::.::.||:|...|..|.|||.|:...|
 Frog   306 LWNSNSLPNDITLMYNPSRHASLPPFPLRNDCHAAQMDSLGLGYLCQSSHSEPNISASLRGTD-- 368

Human   198 HFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGV-------LTIPQNHKFPKEKERNI 255
                                             ||....||       ||.|:||         .
 Frog   369 ---------------------------------LLRDIKGVKQHITQRLTSPRNH---------T 391

Human   256 PSLTSFVPKLSVSVRQSDELSP--SNEPPGAL-----VKSLMDPTLRSSDGFIWS--RNMCSFPK 311
            ||     |.|..|.| :..|:|  .:.|.|..     |..|:  :|..||.|..|  ..:||..|
 Frog   392 PS-----PLLCQSPR-AVRLTPLVMDTPRGKAGSDISVNDLV--SLPISDAFAKSAPHKLCSGNK 448

Human   312 TNHHR----------QCLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDI 366
            .:::.          |.|.|.:.:.|                         :.|..|.:..|:.:
 Frog   449 YSNNSPSPAPHIAGDQVLSKNQIYLS-------------------------MDESFIISEEEQGL 488

Human   367 DCHGSKTRKPEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNK 431
            ...|:      ..||:  |:||....|....::..:|:........|...||.|.::..|...|:
 Frog   489 AAPGA------VGNSE--SNRKESLFVQAKCKRTAKILSVFQGGSTELHQSERTMTKRHEEGINQ 545

Human   432 A------ASKRVSLHKN---EAMEPNNILEECT-VLKSLSSVVFD-----DPIDKLPEGCSSMET 481
            :      .|.|:|..:|   :|:..:.|:...| .::::|.:..|     :|::....| :||:|
 Frog   546 SPKWDNILSARLSQRENFVGKAVSADLIIATSTETMENVSEIQEDIDDKREPLEGKDPG-NSMQT 609

Human   482 NIKISIAERAKPEMSRMVPLIHITFPVDG----SPKEPVIAKPSLQTRK----GTIHN-NHSVNI 537
                       |:..:: ||:||||...|    ..|.|.: |.....||    |..|| |||.|:
 Frog   610 -----------PQDGQL-PLVHITFSEQGPQSLKAKSPPL-KQFFMKRKTILCGVPHNVNHSFNV 661

Human   538 PVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKT-SIKTQIFPALGLVDP-- 599
            ...:||:|.|.|.     .|:||::...|..   ..:.|:  :::|. :||:...|.|.|...
 Frog   662 IAQKENEKGKKNR-----KSRTKSACDAPSK---QKQKPL--SINKNMNIKSVPLPPLELTGSTK 716

Human   600 ---RPWQLPRFQKKMPQIAK---KQSTHRTQKPKKQSFPCI-CKNPGTQKSCVPLSVQPTEPRLN 657
               .|.::|  ...:|...|   :.:||.:..|||.:.|.: .::|.|:.:..|          :
 Frog   717 RLRTPQKVP--HSHLPGSDKGVERSNTHLSMCPKKNNSPVVTTRHPLTRANTAP----------D 769

Human   658 YLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSH 722
            :..:.|.|:||::.:...||.||||...|:|....:......:..||..||.|.:..::|...|.
 Frog   770 FTSITYHDIFKKLEANNEGPEIYEMVVMPLYPQTGDPVDVSGSVCRESHSAMSKKGSSSKVARSS 834

Human   723 SERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENG-DGISEPDWQ- 785
            |..:||.|.:  .|:.:.|..:.:.....:||.|.::::.. |:...   :|:| ..||..|||
 Frog   835 SANESNRRRK--PKRPNSKSKRCASRSSLKHKNLDARDEDC-AIEEK---VEHGVIVISGTDWQI 893

Human   786 IKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTS 850
            |:.|.|....||:.:   .:...|.|....:|     |||:::|.::|.|           |.||
 Frog   894 IEKSNNILFDSKESV---AVVLEPFQDNIYHE-----DLSMIKEATIENS-----------LNTS 939

Human   851 -------LRDLQELEELH---------HQIPFIPSEDSWAVPSEKNSNKYVQQEK------QNTA 893
                   ::...|:...|         ..|..:||.||....:..:|   .|||:      .||.
 Frog   940 RTFHDDRVKGSGEMNPNHFDAEVFIQEQPIKSVPSTDSHKRETRSSS---AQQEELEDYKVDNTG 1001

Human   894 SL----SKVNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSI 954
            .:    :|.||.|..|                        |..:...|.
 Frog  1002 GVPSCENKNNAPRETT------------------------EGGTENGYG---------------- 1026

Human   955 TYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDN-NSCQKMANETDPENLN 1018
                |.|:||....|          |:|||:|:.||...||::||::: :|.:.:..:||.|.:|
 Frog  1027 ----FSKSLSTEGDI----------EQLTDDLIHCLVENLLSIDERESQDSIESINTDTDDEIMN 1077

Human  1019 LVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEI 1083
                          .:..|.|...|:      :..:....:|..|: :::|:....|  |||||:
 Frog  1078 --------------DQDQKCKSPSHN------ECNKSANTTNIDKL-ADSSINGSFP--WTKGEV 1119

Human  1084 LGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCL 1148
            |||||||||||||||||:|||.|||.||:|:.:.|:|||:||||||||||||.|||||.|||||.
 Frog  1120 LGKGAYGTVYCGLTSQGELIAAKQVVLDSSDPVTAQKEYKKLQEEVDLLKALDHVNIVGYLGTCR 1184

Human  1149 QENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMP 1213
            ::|.|:|||||||||||:||:.|||||.||||.|||||||||:.|||.|.|:||||||||:||||
 Frog  1185 EDNMVTIFMEFVPGGSIASILRRFGPLQEMVFIKYTKQILQGIVYLHSNRVIHRDIKGNNLMLMP 1249

Human  1214 TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPY 1249
            .|||||||||||:||.:...:||.|:||:|||||||
 Frog  1250 NGIIKLIDFGCAKRLTYLNKSGTQSEMLRSMHGTPY 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	132/174 (76%)
map3k19	XP_002941471.3	ANKYR	1..>184	CDD:440430
		ANK repeat	38..68	CDD:293786
		ANK repeat	70..128	CDD:293786
		ANK repeat	130..174	CDD:293786
		Protein Kinases, catalytic domain	1112..>1285	CDD:473864	131/174 (75%)