DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K19 and map3k19

DIOPT Version :9

Sequence 1:	XP_011510193.1	Gene:	MAP3K19 / 80122	HGNCID:	26249	Length:	1345	Species:	Homo sapiens
Sequence 2:	XP_002941471.3	Gene:	map3k19 / 100488738	XenbaseID:	XB-GENE-6046272	Length:	1285	Species:	Xenopus tropicalis

Alignment Length:	1336	Identity:	389/1336 - (29%)
Similarity:	580/1336 - (43%)	Gaps:	374/1336 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    29 ESLLDICHDTNSSPTDLMTVTKNQNII-LQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQDWQP 92
            |.:.|.|.||.....:..|....|.:. :||.|..:..:.:   .:|::...||||      |:.
Frog   209 EPVCDFCPDTKLPLYNTSTAGGGQTLAHIQSCSPGQGINPN---RNSSIQVTEEDP------WEE 264

Human    93 RTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSH------------------ 139
            ..|           |..|.|::.          ||||   |||...|
Frog   265 AAE-----------VPNPDEVTY----------SSLQ---QAHTTLHEMEGVDRAPDILKGSLAR 305

Human   140 -------PNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 197
                   ||:|..:....:..::.|..|:.:..:.::.::.||:|...|..|.|||.|:...|
Frog   306 LWNSNSLPNDITLMYNPSRHASLPPFPLRNDCHAAQMDSLGLGYLCQSSHSEPNISASLRGTD-- 368

Human   198 HFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGV-------LTIPQNHKFPKEKERNI 255
                                             ||....||       ||.|:||         .
Frog   369 ---------------------------------LLRDIKGVKQHITQRLTSPRNH---------T 391

Human   256 PSLTSFVPKLSVSVRQSDELSP--SNEPPGAL-----VKSLMDPTLRSSDGFIWS--RNMCSFPK 311
            ||     |.|..|.| :..|:|  .:.|.|..     |..|:  :|..||.|..|  ..:||..|
Frog   392 PS-----PLLCQSPR-AVRLTPLVMDTPRGKAGSDISVNDLV--SLPISDAFAKSAPHKLCSGNK 448

Human   312 TNHHR----------QCLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDI 366
            .:::.          |.|.|.:.:.|                         :.|..|.:..|:.:
Frog   449 YSNNSPSPAPHIAGDQVLSKNQIYLS-------------------------MDESFIISEEEQGL 488

Human   367 DCHGSKTRKPEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNK 431
            ...|:      ..||:  |:||....|....::..:|:........|...||.|.::..|...|:
Frog   489 AAPGA------VGNSE--SNRKESLFVQAKCKRTAKILSVFQGGSTELHQSERTMTKRHEEGINQ 545

Human   432 A------ASKRVSLHKN---EAMEPNNILEECT-VLKSLSSVVFD-----DPIDKLPEGCSSMET 481
            :      .|.|:|..:|   :|:..:.|:...| .::::|.:..|     :|::....| :||:|
Frog   546 SPKWDNILSARLSQRENFVGKAVSADLIIATSTETMENVSEIQEDIDDKREPLEGKDPG-NSMQT 609

Human   482 NIKISIAERAKPEMSRMVPLIHITFPVDG----SPKEPVIAKPSLQTRK----GTIHN-NHSVNI 537
                       |:..:: ||:||||...|    ..|.|.: |.....||    |..|| |||.|:
Frog   610 -----------PQDGQL-PLVHITFSEQGPQSLKAKSPPL-KQFFMKRKTILCGVPHNVNHSFNV 661

Human   538 PVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKT-SIKTQIFPALGLVDP-- 599
            ...:||:|.|.|.     .|:||::...|..   ..:.|:  :::|. :||:...|.|.|...
Frog   662 IAQKENEKGKKNR-----KSRTKSACDAPSK---QKQKPL--SINKNMNIKSVPLPPLELTGSTK 716

Human   600 ---RPWQLPRFQKKMPQIAK---KQSTHRTQKPKKQSFPCI-CKNPGTQKSCVPLSVQPTEPRLN 657
               .|.::|  ...:|...|   :.:||.:..|||.:.|.: .::|.|:.:..|          :
Frog   717 RLRTPQKVP--HSHLPGSDKGVERSNTHLSMCPKKNNSPVVTTRHPLTRANTAP----------D 769

Human   658 YLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSH 722
            :..:.|.|:||::.:...||.||||...|:|....:......:..||..||.|.:..::|...|.
Frog   770 FTSITYHDIFKKLEANNEGPEIYEMVVMPLYPQTGDPVDVSGSVCRESHSAMSKKGSSSKVARSS 834

Human   723 SERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENG-DGISEPDWQ- 785
            |..:||.|.:  .|:.:.|..:.:.....:||.|.::::.. |:...   :|:| ..||..|||
Frog   835 SANESNRRRK--PKRPNSKSKRCASRSSLKHKNLDARDEDC-AIEEK---VEHGVIVISGTDWQI 893

Human   786 IKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTS 850
            |:.|.|....||:.:   .:...|.|....:|     |||:::|.::|.|           |.||
Frog   894 IEKSNNILFDSKESV---AVVLEPFQDNIYHE-----DLSMIKEATIENS-----------LNTS 939

Human   851 -------LRDLQELEELH---------HQIPFIPSEDSWAVPSEKNSNKYVQQEK------QNTA 893
                   ::...|:...|         ..|..:||.||....:..:|   .|||:      .||.
Frog   940 RTFHDDRVKGSGEMNPNHFDAEVFIQEQPIKSVPSTDSHKRETRSSS---AQQEELEDYKVDNTG 1001

Human   894 SL----SKVNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSI 954
            .:    :|.||.|..|                        |..:...|.
Frog  1002 GVPSCENKNNAPRETT------------------------EGGTENGYG---------------- 1026

Human   955 TYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDN-NSCQKMANETDPENLN 1018
                |.|:||....|          |:|||:|:.||...||::||::: :|.:.:..:||.|.:|
Frog  1027 ----FSKSLSTEGDI----------EQLTDDLIHCLVENLLSIDERESQDSIESINTDTDDEIMN 1077

Human  1019 LVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEI 1083
                          .:..|.|...|:      :..:....:|..|: :::|:....|  |||||:
Frog  1078 --------------DQDQKCKSPSHN------ECNKSANTTNIDKL-ADSSINGSFP--WTKGEV 1119

Human  1084 LGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCL 1148
            |||||||||||||||||:|||.|||.||:|:.:.|:|||:||||||||||||.|||||.|||||.
Frog  1120 LGKGAYGTVYCGLTSQGELIAAKQVVLDSSDPVTAQKEYKKLQEEVDLLKALDHVNIVGYLGTCR 1184

Human  1149 QENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMP 1213
            ::|.|:|||||||||||:||:.|||||.||||.|||||||||:.|||.|.|:||||||||:||||
Frog  1185 EDNMVTIFMEFVPGGSIASILRRFGPLQEMVFIKYTKQILQGIVYLHSNRVIHRDIKGNNLMLMP 1249

Human  1214 TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPY 1249
            .|||||||||||:||.:...:||.|:||:|||||||
Frog  1250 NGIIKLIDFGCAKRLTYLNKSGTQSEMLRSMHGTPY 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	132/174 (76%)
MAP3K19	XP_011510193.1	S_TKc	1078..1341	CDD:214567	132/172 (77%)
map3k19	XP_002941471.3	ANK repeat	38..68	CDD:293786
		Ank_2	42..128	CDD:403870
		ANK repeat	70..128	CDD:293786
		Ank_2	100..>186	CDD:403870
		ANK repeat	130..174	CDD:293786
		PKc_like	1112..>1285	CDD:419665	131/174 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I11275
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I9211
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D160962at32523
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto152357
Panther	1	1.100	-	-	LDO	PTHR48011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070