Protein Alignment PANK2 and pnk-1

DIOPT Version :10

• Sequence 1: NP_705902.2
• Gene: PANK2 / 80025
• HGNCID: 15894
• Length: 570
• Species: Homo sapiens
• Sequence 2: NP_740867.1
• Gene: pnk-1 / 172327
• WormBaseID: WBGene00004068
• Length: 449
• Species: Caenorhabditis elegans
• Alignment Length: 473
• Identity: 156/473 - (32%)
• Similarity: 232/473 - (49%)
• Gaps: 83/473 - (17%)

Human   142 TSVSSAGE-QAAGDPEGRRQEP--------LRRRASSASVPAV------------GASAEGTRRD 185
            |||:|:.. ...|.|...|:.|        ||.:.::|:...:            ..||.|:...
 Worm     4 TSVTSSRRISPRGSPPNLRRTPPKIRKVLVLREKRAAATEDQIMDDLLLSSKLKRVDSATGSVSP 68

Human   186 RLGSYSGPTSVSRQRVESLR--KKRPLFPW-----------------FGLDIGGTLVKLVYFEPK 231
            |:.:.....:.:.....:||  :|.|..|:                 ..:||||||:|:||....
 Worm    69 RVCAADALPTTTPAASTALRQTQKAPKTPYVILPASDTFEKFRKTSRVSVDIGGTLIKVVYSSVM 133

Human   232 DITAEEEEEEVESLKS-IRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAF 295
            |     ||...|||.. .|||     ||..                |::..::|.:|.  ||..|
 Worm   134 D-----EELPEESLNGHTRKY-----AYED----------------GKRVLVNFKKFT--DMDRF 170

Human   296 IQMGRD-----KNFSSLHTVFCATGGGAYKFEQDFLTIGDLQLCKLDELDCLIKGILYIDSVGFN 355
            |...::     |....:|    .||||:||:.:..:....::|.:.||:..||.|:.::.|.  |
 Worm   171 INFLKEVWTDRKRGDVIH----CTGGGSYKYSEIIMKELGVRLQRTDEMRSLIFGVNFLLST--N 229

Human   356 GRSQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFG 420
            ......|..:.....|.|..|......||.||||||:|:|||.|.|..:|:||.|:|:|||||.|
 Worm   230 VDESFTYHHDAIGRNKFQYRPIAADLIYPFLLVNIGTGISILKVDSPTSYERVGGSSMGGGTFMG 294

Human   421 LCCLLTGCTTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKE---KRE 482
            |..|||....|:|.||||:|||...|||||.|||||.|:..||....:|.|.......|   |::
 Worm   295 LGSLLTPAQNFDELLEMANRGDHRNVDKLVCDIYGGAYDELGLKADLIAGSMAKCNRFEETTKKQ 359

Human   483 AVSKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRINTIAMRLLAYALDYWSKGQLK 547
            ....||:|::.|:.::||||.:|.:.....|:.::.|.|.|:|.:.|.||.|::|::|||||:::
 Worm   360 QHKPEDIAKSLLLMVSNNIGQMAYLYGTRYNLKRIYFGGYFIRQDPITMRTLSFAINYWSKGEIE 424

Human   548 ALFSEHEGYFGAVGALLE 565
            ||:.:||||.||:|:.|:
 Worm   425 ALYLKHEGYLGAMGSFLD 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PANK2	NP_705902.2	PHA03307	<8..>209	CDD:223039	18/89 (20%)
		ASKHA_NBD_PanK-II_Pank2	213..566	CDD:466986	136/379 (36%)
pnk-1	NP_740867.1	ASKHA_NBD_PanK-II_Pank4	115..441	CDD:466973	135/359 (38%)