DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXRED2 and Fmo-2

DIOPT Version :10

Sequence 1:NP_079231.4 Gene:FOXRED2 / 80020 HGNCID:26264 Length:684 Species:Homo sapiens
Sequence 2:NP_610217.1 Gene:Fmo-2 / 35561 FlyBaseID:FBgn0033079 Length:429 Species:Drosophila melanogaster


Alignment Length:519 Identity:90/519 - (17%)
Similarity:156/519 - (30%) Gaps:192/519 - (36%)


- Green bases have known domain annotations that are detailed below.


Human     1 MDQPSGRSFMQVLCEKYSPEN--------------FPYRRGPGVGVHVPATPQ--------GSPM 43
            ||..:.||::.   |.||.||              ....:..|..:.....|:        |.|:
  Fly     8 MDVENSRSYID---ELYSEENCKCQEAIVCLKNAVIGSNKKKGSIISQGIVPRLIALLCNAGKPL 69

Human    44 KDRLNLPSVLVLNSCGITCAGDEREIAAFCAHVSELDLSDNKLQDWHEVSKIVSNVPQLEFLNLS 108
            :.|::...||     |....|.|.::              :.|..::.|..:::.:     .:.|
  Fly    70 QLRIDAGIVL-----GSLAKGTESQV--------------HSLMRFNIVEVLITII-----FDAS 110

Human   109 SNPLSLSVLERTCAGSFSGVRKLVLNNSKASWETVHTILQELPELEEL------FLCLNDYETVS 167
            :|    ..|...|.|:.    :.::....|..:.:|:.:..:..|.::      |.|......:.
  Fly   111 TN----ERLMEACLGAL----QTIVQYPFAPLDLIHSDINNIKRLIQIASPRSSFACQMYVVNIF 167

Human   168 CPSVCCHS---------------LKLLHITDNNLQDWTEIRKLGVMF---PSLDTLVLANNHLNA 214
            .|  .|||               |..|.|.||.......::.|..|.   .|:..:|.|..|  |
  Fly   168 VP--LCHSSHQQKSLCQAEVIPFLARLMICDNTTLQVPALKCLAAMCFTNKSVSNIVHATYH--A 228

Human   215 IEEPADSLARLFPNLRSISLHKSGLQSWEDIDKLNSFPKLEEVRLLGIPLLQPYTTEERRKLVVA 279
            .....|.|..|....|.:.:..|..:....:.:..|.|                  .|..::|..
  Fly   229 DRSILDILTALLSRTRDVQVQLSASRCLTYLHRAGSLP------------------AEDYRIVYK 275

Human   280 RLPSVSKLNGSVVTDGEREDSERFFIRYYVDVPQEEVPFRYHELITKYGKLEPLAEVDLRPQSSA 344
            .||.:::|    .:|...||:.                      .|....|..|||:|...|..|
  Fly   276 TLPCLARL----CSDEFEEDTR----------------------ATAAETLAYLAEIDSELQRLA 314

Human   345 KVEVHF----------------------------NDQ-----VEEMSIRLDQTVAELKK------ 370
            .:..|.                            ||:     :.||...:::.::.||.      
  Fly   315 AISNHLIVSLANLVKCPSVLSRQGAFRCFASLAANDEEIRKRIIEMDGLMEEVLSGLKDGCAEDH 379

Human   371 ----------------QLKTLVQLPTSSMLLYYFDHEAPF---GPEEM-----KYSSRALHSFG 410
                            :|:|:|.....::||.:...:.|.   |..||     |:...||...|
  Fly   380 SVWRPLMDLLSGEPSLELQTVVTSTICNLLLEFSPAKEPMLESGAVEMLCELTKHPDPALRLNG 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXRED2NP_079231.4 CzcO 26..>245 CDD:441675 43/250 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..684
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 681..684
Fmo-2NP_610217.1 PLN02172 3..384 CDD:215116 77/458 (17%)
Blue background indicates that the domain is not in the aligned region.

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