Protein Alignment WWC2 and HUL5

DIOPT Version :9

• Sequence 1: XP_011530571.1
• Gene: WWC2 / 80014
• HGNCID: 24148
• Length: 1216
• Species: Homo sapiens
• Sequence 2: NP_011374.1
• Gene: HUL5 / 852736
• SGDID: S000003109
• Length: 910
• Species: Saccharomyces cerevisiae
• Alignment Length: 528
• Identity: 98/528 - (18%)
• Similarity: 184/528 - (34%)
• Gaps: 151/528 - (28%)

Human    76 IDHINK-TTQIED--PRKQW---RGEQEKMLKDYLSVAQDALRTQKELYHVKEQ----------- 123
            |:.:.| |:.::|  .|:.|   :.|:..|||:.:.:..........|:.:..:
Yeast   373 IEELKKFTSTLKDFTFRQYWELPKSERNPMLKEAVPLLSKVYERDSRLHFLSTENNPTYWENSEK 437

Human   124 -----RLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLR--VKKLKRE 181
                 |....|.||   .|.|:|    |....|......:.|.|..:..:.:..|.  .|:||..
Yeast   438 QFLNLRFYEELQEY---EDLYRE----HLEEESDEDMEKEIDLDKERPPLKSLLLNKMKKRLKSS 495

Human   182 LSQMKQELLYKEQGFETLQQ----------IDKKMSGGQSGYELSEAKAILTELKSIRKAISSGE 236
            |...|.|:|.:...|...::          :|||.......:.|         :.......|:|.
Yeast   496 LRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNL---------INMFTPWASTGM 551

Human   237 KEKQDLMQSLAKLQERFHLDQNIG-RSEPDLRCSPVNSHLCLSRQTLDAGSQTSISG-------- 292
            :::..::.....|::.|:...:|| |.:..|..:.:|          :.|.:..|.|
Yeast   552 RKQSAIISRDNVLEDAFNAFNSIGERFKASLDVTFIN----------EFGEEAGIDGGGITKEFL 606

Human   293 ----DIGVRS------RSNLAEKVRLSLQYEEAKRS-------------MANLKIELSKLD---- 330
                |.|.:.      |:|...::..|:.|:..|..             ..::.|::|..|
Yeast   607 TTVSDEGFKDPKHELFRTNDRYELYPSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLK 671

Human   331 -----SEAWPGAL-DIEKEKLMLINEKEELLKELQFVTPQKRTQD---ELERLEAERQRLEEELL 386
                 |..:..:. |:.....:|.|   .|:|.|...|.:.::.|   |::..|:..:.::   |
Yeast   672 KLLNYSNGFLSSFSDLGSYDSVLYN---NLIKLLNMTTDEIKSLDLTFEIDEPESSAKVVD---L 730

Human   387 SVRGTPSRALAERLRLEERRKELLQKLEETTKLTTY------------LHSQLKSLSA-STLSMS 438
            ...|:.:....:.:.|            ..||:|.|            .|..|..:.| ..:.|.
Yeast   731 IPNGSKTYVTKDNVLL------------YVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMF 783

Human   439 SGSSLGSLAS-SRGSLNTSSRGSLNSL-SSTELYYSSQSDQIDVDYQYKL-DFLLQEKSGY---- 496
            :...|..|.| .|.:::      |:.| |:||.....:.||..||:...| :|..:||..:
Yeast   784 NSIELQMLISGERDNID------LDDLKSNTEYGGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFV 842

Human   497 --IPSGPI 502
              :|..|:
Yeast   843 TSVPQAPL 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWC2	XP_011530571.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809	4/14 (29%)
		DUF342	<283..385	CDD:302792	24/145 (17%)
		YlqD	351..>428	CDD:287979	15/91 (16%)
		C2_Kibra	700..823	CDD:176062
		vWFA	<1058..>1153	CDD:294047
		Phage_Nu1	<1117..1192	CDD:294991
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	98/528 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900