DRSC/TRiP Functional Genomics Resources

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Protein Alignment WWC2 and TOM1

DIOPT Version :9

Sequence 1:XP_011530571.1 Gene:WWC2 / 80014 HGNCID:24148 Length:1216 Species:Homo sapiens
Sequence 2:NP_010745.3 Gene:TOM1 / 852068 SGDID:S000002865 Length:3268 Species:Saccharomyces cerevisiae


Alignment Length:1485 Identity:280/1485 - (18%)
Similarity:504/1485 - (33%) Gaps:503/1485 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    75 YIDHINKTTQIEDPRKQWRGEQ----------------EKMLKDYLSVAQDALRTQKELYHVKEQ 123
            :|:::.|:.:.|.....|..:.                |::.||.|  .:..|.:..:::.:.:.
Yeast  1370 FIEYLEKSLKPEHVNTPWFSKALYVYEIILAKSELPHLEELSKDVL--LRYPLLSMAKVFRIPDP 1432

Human   124 RLALALDEYVRLNDA---YKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRV----KKLKRE 181
            ......|..:|::|.   |...::|...:|  .|....|..:|.::.|.:..|:|    :||.:.
Yeast  1433 MKQKLFDILIRVSDISNFYSALATSRILIF--YSRDELYANNIARSGILSRLLKVIGSFQKLDKI 1495

Human   182 LSQMKQELLYKEQGFETLQQID-------------KKMSGGQSGY-ELS---EAKA--------- 220
            .......||...:.|||.:.:|             :.:.||.... ||:   |.||         
Yeast  1496 NFLESSFLLLTRRCFETTENVDALIRAEINRSFTARPLGGGDDAVRELTTILEEKAHVVMRSPSQ 1560

Human   221 ---ILTELK--------------SIRKAISSGEKEKQDLMQSLAK--LQER---FH--LDQNIGR 261
               :|.|..              |:::.:  |||:|.....|..|  :.||   .|  |.|.:..
Yeast  1561 FIDVLCETARFHEFDDQGALVDYSLKRFL--GEKDKNTQASSTEKSDIYERTGIMHLLLSQLMAA 1623

Human   262 SEPDLRCSPVNS---------HLCLSRQTLDA-------------GSQTSISGDIGVRSRSN-LA 303
            ||.|....|.||         .|..||..:.|             .|......:....||.| .|
Yeast  1624 SEKDWLSEPANSSDLPENKKAQLDPSRNPVCAYMIFLLKLLVELVSSYNQCKFEFLTFSRRNTYA 1688

Human   304 EKVR---LSLQY----------------EEAKR------------------------SMANLKIE 325
            |:.|   .::.:                .||||                        :..::|:.
Yeast  1689 ERPRPRTTAINFFLYRLLDKPVGTDHDKHEAKRREVIGMLARSVIIGFLATVQDDRTTKTDVKLA 1753

Human   326 ------LSKLDSEAWPGAL--DIEKEKLMLINEKE-----ELLKELQFV-TPQKRTQDELERLEA 376
                  :.|...||...|:  .....||:..|..:     .::..:.:| .|..|...:..::||
Yeast  1754 DPHMNFIRKFAIEAIIKAIRNATSSSKLLESNHLKLDMWFRIITSMVYVQAPYLRQLLDSNKVEA 1818

Human   377 ERQRLEEELLSVRGTPS---RALA-------------------------------ERLRLE---- 403
            ::.:|.:.::.: |.||   .|:|                               |..::|    
Yeast  1819 DQYQLCKLVIDL-GLPSVITEAMASIDLNYPFSKKIFNVAVEALNTISSTRNNFSEHFKIEDHDE 1882

Human   404 ------ERRKELLQKLEETTKLTTYLHSQLKSLSASTLSM-SSGSSLGSLASSRG---------- 451
                  |..||.:..:.:.:.|..|....::.......|: ....::..:.|..|          
Yeast  1883 VEDEVDESDKEEIPDMFKNSALGMYDVEDIEEDDDDDTSLIGDDDAMAFVDSDNGFEVVFSDEDD 1947

Human   452 ------SLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHENEV 510
                  :.:..|....|.|||.  ..||.:|..||||:      :.:..|.|.:           
Yeast  1948 DMGEEDADDARSDSEENELSSE--MQSSTADGTDVDYE------VDDADGLIIN----------- 1993

Human   511 VKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHD 575
            :..||               |....:|:...::    |.||.|                 .:..|
Yeast  1994 IDQPS---------------GDDEEMADYDANI----SHSSHS-----------------ENEDD 2022

Human   576 ASLHQFTADFEDCELSSHFADISLIENQI-LLDSDSGGASQSLSEDKDLNECAREPLYEGTADVE 639
            ||:.  ..:..|.||||.: |:.|.:..: ..|.|||.:|.|:| |:|......||:    ....
Yeast  2023 ASMD--VIEVYDDELSSGY-DVDLSDYDVDESDWDSGLSSLSIS-DEDSESSEDEPI----NSTR 2079

Human   640 KSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQI 704
            ....:||.:...|.:.|..|...|:|.   |.||:..       :|.: :|.|:..:.   :|..
Yeast  2080 MGDSRRRWLIAEGVELTDDSQGESEED---DRGVFRG-------IEHI-FSNENEPLF---RVHD 2130

Human   705 GLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDV 769
            .:|:              ||.|..:    ::.:|..|:  |:..:|.|.|.:   ..:|.|.|  
Yeast  2131 EMRH--------------RNHHRSI----NRTHFHSAM--SAPSLSLLNRGR---RNQSNLIN-- 2170

Human   770 FRVAISQTALQQKTLRV-DLCSVS----------KHRREECLAGTQISLADLPFS---------- 813
               .:..|.|:|....: |..:|:          .|..|..::|   |..|.|..          
Yeast  2171 ---PLGPTGLEQVENDISDQVTVAGSGSRPRSHHLHFSEVLVSG---SFFDEPVLDGIILKSTVS 2229

Human   814 --SEVFTLWYN-------LLPS-------------KQMPCKKNEE---NEDSVFQPNQPLVDSID 853
              .::|.::|:       ::|:             |.:..|:.:|   |::.:|  |:..|:|  
Yeast  2230 RWKDIFDMFYDSKTYANCIIPTVINRLYKVSLALQKDLENKREQEKLKNKNLLF--NEAKVES-- 2290

Human   854 LDAVSALLARTSAELLAVEQELAQEEEEESGQEEP-----RGPD----GDWLNTYFLCCW--ELK 907
                     ..|::.::|||:..||........||     :|.:    |..::..|:...  :::
Yeast  2291 ---------HNSSDAISVEQDDIQESNVTHDDHEPVYVTIQGSEVDIGGTDIDPEFMNALPDDIR 2346

Human   908 DDVFTRLTVKPLLTMLREASDEIVAEKEAE----VKLPED--------------------SS--- 945
            .|||.: .|:......|..||..|..:|.:    ..:|||                    ||   
Yeast  2347 ADVFAQ-HVRERRAEARLNSDHNVHSREIDSDFLEAIPEDIREGILDTEAEEQRMFGRIGSSADV 2410

Human   946 --CTEDLSSCTSVPEMNED-GNRKESNCAKDLRSQPPTRI---PTLVDKETNTDEAANDNMAVRP 1004
              ..:|:|:.....|...| ||..:.|.| |...:.|.||   |.:            |...:..
Yeast  2411 IRADDDVSNNDEEVENGLDHGNSNDRNNA-DPEKKKPARIYFAPLI------------DRAGIAS 2462

Human  1005 KERSSLSSRQHPFVRSSV-------IVRSQTFSPGERNQYICRLNRSDSDSSTLAKKSLFVRNST 1062
            ..:|...|:  |:::..:       :..|:.......|.::..|:....|..:|.|    |.|..
Yeast  2463 LMKSVFISK--PYIQREIYHELFYRLCSSKQNRNDLMNTFLFILSEGIIDQHSLEK----VYNII 2521

Human  1063 ERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELD-LQASLTRQSRL-------NDEL-------- 1111
            ..|::...:|   :.:|:...:|...|..:..:: ||:.:...|||       :|.|        
Yeast  2522 SSRAMGHAKT---TTVRQLPSDCTPLTVANQTIEILQSLIDADSRLKYFLIAEHDNLIVNKANNK 2583

Human  1112 ---QALRD--LRQKLEELKAQGETDL--PPGVLEDERFQRLLKQAEK-----------QAEQSKE 1158
               :||.|  ||..|..|.:..:..|  ...||.| ...|:|:...|           :...||:
Yeast  2584 SRKEALPDKKLRWPLWHLFSLLDRKLITDESVLMD-LLTRILQVCTKTLAVLSTSSNGKENLSKK 2647

Human  1159 EQKQGLNAEKLMRQVS---KDVC--RLREQSQKVPRQVQSFREKIAYFTRAKISI 1208
            ......:.:.||:.:|   .|.|  |:.:|:..:...:...:..::.||:..:|:
Yeast  2648 FHLPSFDEDDLMKILSIIMLDSCTTRVFQQTLNIIYNLSKLQGCMSIFTKHLVSL 2702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WWC2XP_011530571.1 WW 12..41 CDD:278809
WW 59..88 CDD:278809 3/12 (25%)
DUF342 <283..385 CDD:302792 26/172 (15%)
YlqD 351..>428 CDD:287979 18/126 (14%)
C2_Kibra 700..823 CDD:176062 27/152 (18%)
vWFA <1058..>1153 CDD:294047 28/128 (22%)
Phage_Nu1 <1117..1192 CDD:294991 20/92 (22%)
TOM1NP_010745.3 DUF908 92..387 CDD:399185
DUF913 448..>683 CDD:399192
MSCRAMM_ClfB <1879..2061 CDD:411414 45/239 (19%)
DUF4414 2328..2357 CDD:405126 6/29 (21%)
HUL4 2385..3268 CDD:227354 66/341 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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