Protein Alignment WWC2 and kibra

DIOPT Version :10

• Sequence 1: NP_001397793.1
• Gene: WWC2 / 80014
• HGNCID: 24148
• Length: 1216
• Species: Homo sapiens
• Sequence 2: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 1267
• Identity: 409/1267 - (32%)
• Similarity: 636/1267 - (50%)
• Gaps: 228/1267 - (17%)

Human    11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYY 75
            |||.||:.|:|:|||.:||||..::|:|:||||..|||.:|.||||||||.|||..:||.||.||
  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYY 119

Human    76 IDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYK 140
            |:|:.::||:||||::|:..||:||.||||.|||.|..::|::.||:|||..|.:||..|
  Fly   120 INHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL----- 179

Human   141 EKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETLQQIDKK 205
            :.::|.:||.|.|||.:::||::|:|::...|.||.:||:||:.:..::.|.|:|..||..:.:|
  Fly   180 KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEK 244

Human   206 MSGGQSG-YELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCS 269
            ::..::| |:::|..||..|:..:.|::.||||.:::||:||.:::      ..:||.:    .|
  Fly   245 INARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIK------NELGRQQ----IS 299

Human   270 PVNSHLCLSRQTLDAGSQTSISGDIG--VRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSE 332
            ..||.|......:...|||.:.|..|  :...:..||..:...||.|.::.:..|:.:|:.....
  Fly   300 EENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVER 364

Human   333 AWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALA 397
            ..||.|:.:|::::||.|||:||.:|..::.:.|:::|...:...|.:|||:|.......:..:|
  Fly   365 IEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVA 429

Human   398 ERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSA-STLSMSSGSSLGSLASSRGSLNTSSRGSL 461
            .|||..|.::.||.||:|..|.|..|..:|||.|: ||.|:|||||||||         |:..|.
  Fly   430 NRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------STASSK 485

Human   462 NSLSSTELY-----YSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSG 521
            ::||.|::|     ..|..|.:|:..:.:..|...::....|      :|
  Fly   486 SALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHP------VH--------------- 529

Human   522 LCGVAAAATGHTPPLAEAPKSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQ------ 580
                        |.|.:...:..:||.|||||..:||.||:          .::|...|
  Fly   530 ------------PVLQQQQSAEVTLSPRSSLSMETPPASPM----------KYNAGADQTPQALK 572

Human   581 --------------FTAD---------FEDCELSSHFADISLIENQILLDSDSGGASQSLSEDKD 622
                          :||.         ....:|.|...|..::|.::          |.|:....
  Fly   573 EEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKL----------QKLNMGTP 627

Human   623 LNECAR--EPLYEGTADVEKSLPKRRVIHLLG-EKTTCVSAAVSDESVAGDSGVYEAFVKQPSEM 684
            ||....  .|:.|..:.::  ||:..:..... ..|..||||||:|||||||||:||
  Fly   628 LNLAVAPLSPISEKPSLLD--LPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEA-------- 682

Human   685 EDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHAF--LIPHTSKVYFRVAVLPSS- 746
                 |...:...|.|||||||:|..:....:|.:.:..||.|.  .....|:||.|.|:||:|
  Fly   683 -----SRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSL 742

Human   747 TDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREECLAGTQISLADLP 811
            |.:    |||.....:..:|||.|.|.|:...|..|:|:|.:.::: .::||.:...|||:|:
  Fly   743 TSI----RTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMT-GQKEEIIGTVQISMAE-- 800

Human   812 FSSEVFTL-WYNLLPSKQMPCKKNEENEDSVFQPNQPLVDSIDLDAVSALLARTSAELLAVEQEL 875
            |:.|..|| |||:|.||.:|.                 .:|:|:.:.||  |..:|.:.|.....
  Fly   801 FNPEDSTLKWYNVLSSKFIPS-----------------FESLDIPSTSA--AAAAAAVAASNAPN 846

Human   876 AQEEEEESGQEEP-RGPDGDWLNTYFLCCWELKDDVFTRLT-VKPLLTMLREASDEIVAEKEAEV 938
            .....|||..|.. .......|......|.||::.:...|. :.||..  .|.||:...::|.|:
  Fly   847 PGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNE--PECSDDDDDDEEEEL 909

Human   939 KLPEDSSCTEDLSSCTSVPEMNEDG-------NRKESNCAKDLRSQPPTRIPTLVDKETNTDEAA 996
                     :|....:.|..||...       |.|:.                ..|||||||.
  Fly   910 ---------DDKQLVSDVGLMNSSSMLHAYLQNMKQE----------------FADKETNTDR-- 947

Human   997 NDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGE---RNQYICRLNRSDSDSST---LAKKS 1055
                |..|::    |..|...:....:.|||||:|.|   :|:|.||||||||||:.   :|..:
  Fly   948 ----AYLPEK----SRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHT 1004

Human  1056 LFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDELQALRDLRQK 1120
             |.|.:.||||||......:||.:......| ||||||||||||..::...|||::..|::|::.
  Fly  1005 -FQRGAAERRSLRFHSKAPKSVTKLHHTHIP-RTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEV 1067

Human  1121 LEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVSKDVCRLREQSQ 1185
            |::.....:..:....:|:|.||||:.:|: .|:..:|.|.|     ||:.:.:|::.:||:  .
  Fly  1068 LQKACENKDPLVAAWAIENEEFQRLVARAD-PAKCPEERQLQ-----KLLMKTAKEIHKLRK--T 1124

Human  1186 KVPR---QVQSFREKIAYFTRAKISIPSLPAD 1214
            |||:   .:.||:|||.:|||..:|:|.||::
  Fly  1125 KVPKGCPDLVSFKEKITFFTRKGLSVPELPSE 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWC2	NP_001397793.1	WW	12..41	CDD:459800	15/28 (54%)
		WW	59..88	CDD:459800	16/28 (57%)
		Smc	<173..>430	CDD:440809	79/259 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..462		8/20 (40%)
		C2_Kibra	700..823	CDD:176062	46/126 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	873..895		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	935..1015		18/86 (21%)
		Interaction with PRKCZ. /evidence=ECO:0000269|PubMed:24682284	1055..1074		8/18 (44%)
		PRK10929	1103..>1185	CDD:236798	22/81 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1148..1167		5/18 (28%)
kibra	NP_001034055.1	WW	57..87	CDD:238122	16/29 (55%)
		WW	103..132	CDD:459800	16/28 (57%)
		C2_Kibra	693..813	CDD:176062	46/126 (37%)