DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWC2 and ptr1

DIOPT Version :9

Sequence 1:	XP_011530571.1	Gene:	WWC2 / 80014	HGNCID:	24148	Length:	1216	Species:	Homo sapiens
Sequence 2:	NP_594902.1	Gene:	ptr1 / 2542537	PomBaseID:	SPAC19D5.04	Length:	3227	Species:	Schizosaccharomyces pombe

Alignment Length:	1289	Identity:	244/1289 - (18%)
Similarity:	411/1289 - (31%)	Gaps:	427/1289 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   113 TQKELYHVKEQRLALALDEYVRLNDA---------------YKEKSSSHTSL------------- 149
            |:..:..:|:..::|..|..:...||               :.|..|||.:|
pombe   778 TEFTIVSLKQATISLIKDSNMGHEDANNFLHFSIVGNLLTIFAELFSSHAALKKAGNLPLVQLFI 842

Human   150 ----FSG--------SSSSTKYD--------PDILKAEISTTRLRVKKLKRELSQMKQELLYKEQ 194
                ::|        .|.:|..|        .|.:....|.|.:...|.::|..:.|::.|.::.
pombe   843 SPSRYAGIFDILCNIKSIATSLDIHICLGVSDDFVLCSDSLTTIVTDKDEKEKFETKKKELTQDS 907

Human   195 GFETLQQIDKKMSGGQSGYELSEAKAILT------------ELKSIRK-----------AISSGE 236
            .|...|.|....|  |..|.:|:....||            |.|.|.|           .|:...
pombe   908 SFCKFQNIRSNFS--QIAYGVSKFFTSLTRALGNTSVQDFNEYKMIHKLGSNIALVVDELINLSS 970

Human   237 KEKQDLMQSLAKLQERFHLDQNIGRS----EPDLRCSPVNSHLCLSR-----QTLDA--GSQTSI 290
            |:.....|||:.......|...:|.|    |.|   |.|...|.:||     :|:|.  ....::
pombe   971 KQITSHPQSLSIASLEASLIFVLGASSIIREDD---SKVTLVLLISRLLGGCRTMDVLISLNETV 1032

Human   291 SGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLD-----SEAWPGALDIEKEKLMLINE 350
            ||...:..|..|::..|:.|....   ::.||.:..:..|     |:....||..|.:.....|.
pombe  1033 SGFFRLSDRDPLSKSNRVLLALSS---TLLNLILVFTSADFMSETSKTLNMALKSEFDMTDFNNS 1094

Human   351 KEELLKELQ---FVTPQK--RTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELL 410
            ..:|:..|.   |::...  |:.|:|......|..|           :..|:...:.|:..|.::
pombe  1095 GSKLMHVLHARIFISVLHLWRSADDLHLPYITRALL-----------TNVLSNCYQFEDGIKNVV 1148

Human   411 QKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQS 475
            .                                                |:|:| .|.:......
pombe  1149 D------------------------------------------------SINNL-RTSIANGDIK 1164

Human   476 DQIDV--DYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAE 538
            :.:||  |.....:|.|:|.:..:...|.:..|||               |:..|..     |.|
pombe  1165 EPLDVVTDDNTNSNFSLEETNASVTDMPESEKHEN---------------GIFQAYL-----LKE 1209

Human   539 APKSVAS----LSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADF----EDCELSSHFA 595
            .|..:.|    |.|:.             :|.|..| :|::..|:|...||    :|.:::   |
pombe  1210 MPNDIVSQFEMLKSKQ-------------IELTVQM-ASYEGDLNQNLCDFLYTRDDVQMN---A 1257

Human   596 DIS-------LIENQILLDSDS-----------GGASQSLSEDKDLNECAREPLYEGTADVEKSL 642
            |:.       ::|.:.|..|..           |..|..:|.|...|:.....|.|....:|
pombe  1258 DVQFSVTSGLIVEIKKLAQSTDCKAKNQLGPAVGLLSLFISHDFTQNKAKNCVLSELNFFLE--- 1319

Human   643 PKRRVIHLL-------GEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVET- 699
                ::|.|       ..||:.|......|.:..||       |:|.|.|   ::.||.::..|
pombe  1320 ----LLHSLNNGLPSDSHKTSIVCILYLLEVLLADS-------KKPDEFE---FNSEDCSLKLTD 1370

Human   700 AQVQIGLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSS-----------TDVSCLF 753
            ..:.:.|.......|.::.:..|.:.:..::...    |||.||.:|           :.:..||
pombe  1371 GAITVDLASQKHIMSSVITLLSLNSANLGVVVSA----FRVVVLLTSASEMIHTFVKLSGLPSLF 1431

Human   754 RT----------KVHPPTESIL--------------FNDVFRVAISQ------------TALQQK 782
            :.          .:|.|..|||              |:|:..:...|            .|..:.
pombe  1432 KAMRACSGFCNESLHIPFISILRRLLEFDEVVELMMFDDLVNIFKLQGRARKTELHGFIRANAEM 1496

Human   783 TLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQP 847
            .||...|.: |..::.|:.|                   :..|..:....:.:|:...|.|..|
pombe  1497 VLRSPECFI-KILKDCCVLG-------------------HFTPESEHYYLELKESLPGVLQNGQ- 1540

Human   848 LVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRG---PDGDWLNTY--FL--CCWE 905
                .|||.....::......| :::.:...|..:.....|..   |:.|.|..|  ||  |..|
pombe  1541 ----TDLDPSKEQMSSVIVSFL-LDELMDLTETRQFSDRSPNSEFTPENDSLYMYNVFLLQCLTE 1600

Human   906 LKDDV---------FTRLTVKPLLTMLREASDEIVA---EKEAEVKLPEDSSCTEDLSSCTSVPE 958
            |....         |......|...:.|:.:..:|.   ||    .||         ..|..:.|
pombe  1601 LLSGYNACKRCFLNFQPRRKAPFFNLSRKYNSYLVGFFLEK----LLP---------FGCIRLSE 1652

Human   959 MNEDGNRKE---SNCAKDLRSQPPTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRS 1020
            .||  .||.   ||.|          |..||.....::|  ....||....|..|:| ...|.:|
pombe  1653 NNE--VRKAFSVSNWA----------ISILVFLCAYSNE--QQTQAVDEIRREVLTS-VLKFYKS 1702

Human  1021 SVIVRSQTFSPGERNQYICRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSV---LRRTT 1082
                 |.:||. ....|.|:|         |....|..|       |...:||.|..   |.|.:
pombe  1703 -----SSSFSE-NLEAYYCKL---------LVLAELCYR-------LCDAQTVSQKAPNHLLRRS 1745

Human  1083 QECPVRTSLDL-----------ELDLQASLTRQSRLNDELQALRDLRQKLEELK------AQGET 1130
            |:..|:|.:||           |:|:...::|        :.:|.:.:.|:.|.      :|...
pombe  1746 QDQNVKTMIDLGYIPTLTNAISEIDMNYPVSR--------KVVRHILKPLQLLTKEAIFLSQTNP 1802

Human  1131 DLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVSKDVCRLREQS 1184
            :...|..:|....:.|..:.:::..|..|:...|....::.....|:....:::
pombe  1803 EALSGAAQDSMGDQSLSSSSEESSDSDREEPPDLYRNSVLGIFQGDIVNENDEN 1856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC2	XP_011530571.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		DUF342	<283..385	CDD:302792	23/113 (20%)
		YlqD	351..>428	CDD:287979	11/81 (14%)
		C2_Kibra	700..823	CDD:176062	26/169 (15%)
		vWFA	<1058..>1153	CDD:294047	22/114 (19%)
		Phage_Nu1	<1117..1192	CDD:294991	10/74 (14%)
ptr1	NP_594902.1	DUF908	96..367	CDD:283630
		DUF913	436..735	CDD:283642
		HARE-HTH	<1930..2018	CDD:294801
		DUF4414	2267..2347	CDD:291075
		HUL4	2314..3227	CDD:227354
		HECTc	2870..3225	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900