Protein Alignment PHC3 and ph-p

DIOPT Version :9

• Sequence 1: XP_005247846.1
• Gene: PHC3 / 80012
• HGNCID: 15682
• Length: 1011
• Species: Homo sapiens
• Sequence 2: NP_476871.2
• Gene: ph-p / 31181
• FlyBaseID: FBgn0004861
• Length: 1589
• Species: Drosophila melanogaster
• Alignment Length: 1159
• Identity: 272/1159 - (23%)
• Similarity: 420/1159 - (36%)
• Gaps: 311/1159 - (26%)

Human     8 DHSTAMDTEPNPGTSSVS-----------TTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQV 61
            |.:..|..:..|.|.::.           |.|.:...|.:...:.:.||.|..|.:.:     |.
  Fly   573 DGTQGMFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTN-----QT 632

Human    62 IQQALHRPPSSAAQYLQQMYAAQQQH----LMLH------------TAALQQQHLSSSQLQ---- 106
            .||.|....:...|..||:.||..|.    :|.|            |...|.|.|..::::
  Fly   633 QQQQLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMRNKQQ 697

Human   107 ----SLAAVQASLSSGRPSTSPTGSVT-----QQSSMSQTSIN--------LSTSPTPAQLISRS 154
                :||.::..:..........|.:|     ||::..|..:|        :||:.||..|.:..
  Fly   698 PVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQ 762

Human   155 QASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQ 219
            ...::|:..:.:|       ...|...|.|..|:.|.::   ...:||:|           ...|
  Fly   763 TLHAATAAGVDKQ-------QQQLQLFQKQQILQQQQML---QQQIAAIQ-----------MQQQ 806

Human   220 SAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGES 284
            .||.|.|     .|:...:|..|     ..:..|...:...:..|..::..||    |..::...
  Fly   807 QAAVQAQ-----QQQQQQVSQQQ-----QVNAQQQQAVAQQQQAVAQAQQQQR----EQQQQVAQ 857

Human   285 PSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSKVSHHQLILQQQQQQIQ-- 347
            ...:.:......|..|.| :||..:  |..|...:.||:          |:|||.||.|||.|
  Fly   858 AQAQHQQALANATQQILQ-VAPNQF--ITSHQQQQQQQL----------HNQLIQQQLQQQAQAQ 909

Human   348 -----PITLQNSTQDPPPSQHCIP---LQNHGLPPAPSNAQSQH--CSPIQSHPSPLTVSPNQSQ 402
                 ....|...|.....|:.|.   :|..|.....::.|.||  ...:|....|.:||.:.:.
  Fly   910 VQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSSTTP 974

Human   403 -------------SAQQSVVVSPPPPHSPSQSPT---IIIHPQ---------------------A 430
                         ||..::..:..|....|.|||   :.|..|                     |
  Fly   975 AGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQTQSA 1039

Human   431 LIQPH-PLVSSAL------QP-GPNLQQSTANQVQA-TAQLNLP-SHLPLPASPVVHIGPVQQSA 485
            .:..| .|:|:.:      || ||.....|.|.:.| |:.:|.. .|  |..:|.|.:.....:.
  Fly  1040 QVHQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGH--LSTAPPVTVSVTSTAV 1102

Human   486 LVSPGQQIV--SPSHQQYSSLQSSP-------------IPIASP------PQMSTSPPAQIPPLP 529
            ..||||.::  :.|.....|:.::|             :||.||      ....|:|.:..|...
  Fly  1103 TSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCTTPKSSTPATV 1167

Human   530 LQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDP 594
            ..|:::.....|.||.|.               |......|.:....|.:...|..||||:...|
  Fly  1168 SASVEASSSTGEALSNGD---------------ASDRSSTPSKGATTPTSKQSNAAVQPPSSTTP 1217

Human   595 PVGMHLNQCHLHKVFSLKVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSPAAITVGRGEDLTSE 659
                                  ..|..:|.|:.: .|..:  |....|.:...||.|.|...|:
  Fly  1218 ----------------------NSVSGKEEPKLA-TCGSL--TSATSTSTTTTITNGIGVARTT- 1256

Human   660 HPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMHSSIPSIENKPPQAI 724
                        ||.:.|...:.:..|...:         .:..|.:|:..|||.:.....|:|:
  Fly  1257 ------------ASTAVSTASTTTTSSGTFI---------TSCTSTTTTTTSSISNGSKDLPKAM 1300

Human   725 VKPQILTHVIEGFVIQEGLEPFPVSRSSL----LIEQPVKKRPLLDNQVINSVCVQPELQNNTKH 785
            :||.:|||||:||:|||..|||||:|...    :.::|.||:.
  Fly  1301 IKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKA---------------------- 1343

Human   786 ADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRY-----NVSCS 845
                  |..||:..........|:::.||.||||.:..: |:.||:|:..|:::.     .|...
  Fly  1344 ------TMQEDIKLSGIASAPGSDMVACEQCGKMEHKAK-LKRKRYCSPGCSRQAKNGIGGVGSG 1401

Human   846 KKFALSRWN----------RKPDNQSLGHRGRRPSGPD--------GAAREHILRQLPITYP-SA 891
            :...|....          .:.|......:.:..:.|.        ||:.|.....||:... ||
  Fly  1402 ETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPILGASTEVPPMSLPVQAAISA 1466

Human   892 EEDLASHEDSVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLPVAQTEPSIWTVDDVWAFI 956
            ...||....|..|.....|         ..|..|.....|::|::....:...|.|:||||..||
  Fly  1467 PSPLAMPLGSPLSVALPTL---------APLSVVTSGAAPKSSEVNGTDRPPISSWSVDDVSNFI 1522

Human   957 HSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKE 1010
            ..||||||..|:|..|||||||||||||.||::||.:||||||||.|::.|:||
  Fly  1523 RELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGPALKIVAKVESIKE 1576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHC3	XP_005247846.1	SAM_Ph1,2,3	942..1010	CDD:188976	43/67 (64%)
		SAM	944..1011	CDD:197735	45/67 (67%)
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	43/67 (64%)
		SAM	1511..1576	CDD:197735	43/64 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158172
Domainoid	1	1.000	89	1.000	Domainoid score	I7830
eggNOG	1	0.900	-	-		E1_28JS2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3748
Isobase	1	0.950	-	0	Normalized mean entropy	S7881
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8548
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4720
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830