Protein Alignment DOCK5 and spg

DIOPT Version :10

• Sequence 1: NP_079216.4
• Gene: DOCK5 / 80005
• HGNCID: 23476
• Length: 1870
• Species: Homo sapiens
• Sequence 2: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Alignment Length: 2102
• Identity: 711/2102 - (33%)
• Similarity: 1081/2102 - (51%)
• Gaps: 357/2102 - (16%)

Human     4 WIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYTLQNKSKKGIFPETYIHLKE 68
            |||: ..||||||:|::......|:|.:||:|.|:|..:.||||...:.....|:||:||||:|:
  Fly     2 WIPS-NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKD 65

Human    69 ATVEDLGQHETVIPGELPLVQELTSTLREWAVIWRKLYVNNKLTLFRQLQQMTYSLIEWRSQILS 133
            .:..|            |:|.|.|..||||:.||::|||:.:...|:.|:::.:|::|.|.::||
  Fly    66 LSKID------------PVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLS 118

Human   134 GTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNI-LDPDETSTIALFKAHEVASKRIEEK 197
            .|:.:|:..||:..|.:|||.|||.||||||.|:  |.: :||.....:.|:..|  .|.....|
  Fly   119 ATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPRE--GPLAVDPHGIGIVKLYNVH--VSSADNAK 179

Human   198 IQEEKSILQNLDLRGQSIFSTIHTYGLYVNFKNFVCNI-GEDAELFMALYDPDQSTFISENYLIR 261
            ....:..|:....|      .|.|:.||...::|...| |:|||::..|||......:||.:|::
  Fly   180 ASSSRGTLRRKTQR------KILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVK 238

Human   262 WGSNGMPKEIEKLNNLQAVFTDLSSMDLIRPRVSLVCQIVRVGHM----ELKEGKK-----HTCG 317
            ...:|....||:|::...|||||.:.|| ...:.||..::|||.:    .:|:.:|     |...
  Fly   239 ISKDGFSNYIERLHSNCTVFTDLGAADL-NEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPT 302

Human   318 LRRPFGVAVMDITDIIH-----GKVDDEEKQHFIPFQQIAMETYIRQRQLIMSP-LITSHVIGEN 376
            .||||||.|:.:.||.|     .:..||.:.:|..||       ..::...:.| ||.....|:.
  Fly   303 FRRPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ-------CEEKDFHLLPELIIKKSSGKY 360

Human   377 EPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGD 441
            .|:           :.:...||:.||||||.|.|.|.::....|...|| |.||||||::|:|||
  Fly   361 SPI-----------QASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGD 413

Human   442 VRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGKLLEKAIHPGAGYEGISEYKSVVYYQVKQ 506
            ||||:::.|..|||::|.|.|.||:.||:.|.|..|.:|...:...:|.|...:|:|::.|....
  Fly   414 VRNDLFLNLERGEFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNA 478

Human   507 PCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETRDKSE-RAFGVAFVKLMNPDGTTLQDGRHDLV 570
            |.|.|.:::|:.|::.:..|:||.|||.|   ||||:| :.|..:|.:||:..|.||.||.|:|.
  Fly   479 PSWNEMLRLSVPIDKFSTAHVRFEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELY 540

Human   571 VYK-GDNKKMEDAKFYLTLPGTKMEMEEKELQASKNL-VTFTPSKDSTKDSFQIATLICSTKLTQ 633
            ||| .|..|::.|.:      .:::...::.||..:. ..|:   .|:|:.|.:.:|:|||||||
  Fly   541 VYKCEDPAKLQVANY------LRLQCRPRDAQAKMDCGGCFS---RSSKEVFVLRSLLCSTKLTQ 596

Human   634 NVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMM-EMSDSETYDFLVFDAL 697
            |.|||.||.||:..:.|:.:|..::.::..|:||||||.|||||.:.. |..:|..:..|||..|
  Fly   597 NADLLSLLQWRTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVL 661

Human   698 VFIISLIGDIKFQHFNPVLETYIYKHFSATLAY---VKLSKVLNFYVANADDSSKTELLFAALKA 759
            |.|.||:...|||||.||:..||..||:|.|.|   :...:.:..::..|:.....:..|.   :
  Fly   662 VSIFSLLQSNKFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFG---S 723

Human   760 LKYLFRFIIQSRVLYLRFYGQSKDGDEFNNSIRQLFLAFNMLMDRP-LEEAVKIKGAALKYLPSI 823
            |:|:|:.:||||.|:.|..|...: |.|...:..||.|.|.::..| .:..:..:.|.|.....:
  Fly   724 LEYIFKLLIQSRKLFARATGGQYE-DSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVV 787

Human   824 INDVKLVFDPVELSVLFCKFIQSIPDN---QLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQ 885
            :..:|......||.:|....:.:||..   :|::.||:.:..:|...||.:.:.|.|:|.:....
  Fly   788 LEQLKDTLPAPELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKH 852

Human   886 LSGQLDDNSNKPDHEASSQLLSNILEVL------DRKDVGATAVH-----IQLIMERLLRRINRT 939
            |...|   |.:.:....:::||.||..|      .|:.|..|..|     .:.|:..|:|.|:..
  Fly   853 LRMHL---SRRDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTISII 914

Human   940 VIGMNRQSPHIGSFVACMIALLQQMDDSHYSHY---ISTFKTRQDIIDFLMETFIMFKDLIGK-- 999
            :.|.|...|.:   |:|::.|||.:|::||..|   :|..|..:|:.:||.::.:::::|:.:
  Fly   915 MEGSNAVLPQL---VSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDW 976

Human  1000 NVYAKDWMVMNMTQNRVFLRAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETF 1064
            :|:..||:||.:..|.|...::.:||:.|...|:...:|:.|||.:||.|||||||..|||||.:
  Fly   977 HVFPNDWLVMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQY 1041

Human  1065 SQAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFF 1129
            .:.||.||:..:||||..:||:|..||..||..|:.||||||||.|||||.||..|||||:.:|:
  Fly  1042 REPKRLKILHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFY 1106

Human  1130 DMMQCEFNFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCR-KHKYLSSSGEVF 1193
            ||||||  .:..|:|.:.|:|||.|||..:...:||::|:.|...:|||..: ::.....:|..|
  Fly  1107 DMMQCE--QAARGSFRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAF 1169

Human  1194 ALLVSSLLENLLDYRTIIMQDESKENRMSCTVNVLNFYK-EKKREDIYIRYLYKLRDLHRDCENY 1257
            ...|:.|||.|||||:::..:|:::.||:||||:||||| |..|:::|:||:|||.:||...|||
  Fly  1170 IASVTRLLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENY 1234

Human  1258 TEAAYTLLLHAELLQWSDKPCVPHLLQKDSYYVY-----TQQELKEKLYQEIISYFDKGKMWEKA 1317
            |||.:||.|:|.:|.| |:       :..|:..:     .:.:.||:||.||:.||||||.|||.
  Fly  1235 TEAGFTLKLYASMLSW-DR-------ETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKG 1291

Human  1318 IKLSKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKIFI 1382
            |.|.||||..||::.|||..|..:|.:.|.|::||:..:||:||||.||:||.|.|.|:|||.|:
  Fly  1292 IPLCKELAHLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFV 1356

Human  1383 YRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPV---MSLPPSYKDK 1444
            |||.||||...|:.||.|:||:|:.:.:.:||...|.::|.||:|...|:||   .:|..:.  .
  Fly  1357 YRGLEYERIGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAM--V 1419

Human  1445 PVPEQILNYYRANEVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYTFPGILKWFEVKQIST 1509
            ||||:|..:|..|:|.:|.|.||..||..|.||||.::|||||....|...||||:|:||||.:.
  Fly  1420 PVPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTM 1484

Human  1510 EEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEK 1574
            :|::|:|.|.|.:....:.:|..:.|:..|...:::|.||.|.|.:|..||||.|.|::|||:|:
  Fly  1485 QELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQ 1549

Human  1575 YLQEHPE---DQEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPLHERLSSCFRELKEKV--- 1633
            :|:. |:   .|..|:.||.||..|:.:|.:.:.:||:.....::|||.||...|.:||:.:
  Fly  1550 FLKS-PQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGM 1613

Human  1634 ----EKHYGVIT---LPPNLTERKQSRTGSIVLPYIMSSTLRRLSITSVTSSVVSTSSN---SSD 1688
                .:|...|.   |||..||::       |.|...||:|.           .:..||   ..|
  Fly  1614 GRLKRQHSESIVNTPLPPLPTEQR-------VAPATASSSLN-----------ANAHSNYVYDLD 1660

Human  1689 NAPSRPGSDGSILEPLLERRASSGARVEDLSLREEN-----------SENRISKFKRKDWSLSKS 1742
            ...:|||.....::||...:..|   .|.||:..|:           |:|.|.     :.|:...
  Fly  1661 EIYTRPGDTVRPVDPLSSYQTLS---KESLSIPLEDTAAPPVPNRPRSQNFIG-----NGSMDSP 1717

Human  1743 QVIAEKAPEPDLMSPTRKAQRPKSLQLMDNRLS-PF---------------------HGS----- 1780
            :|..::  :|.|.||......|:.: ..|.|.| |.                     ||.
  Fly  1718 EVPPKR--QPTLNSPNAPPLPPRGI-TPDKRASNPLIFNDFGSGDAVGRRHSQQQQQHGQKYSVV 1779

Human  1781 ----SPPQS--TPLSPPP-----------------------LTPKATRTLS----------SPSL 1806
                ..|::  .|.|.||                       ::..::|.|:          |.|:
  Fly  1780 DISYDDPEADQQPHSLPPNFQDGSGGHLSVCFAPNDFRDSGISTTSSRELNHMNLNNLSEDSSSI 1844

Human  1807 QT-----------------DGIAAT-------------------PVPPPP-PPKS---------- 1824
            .|                 |..||.                   |||||| ||||
  Fly  1845 STITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVPPPPIPPKSLAVSSNGVNF 1909

Human  1825 ------KPYEGSQRNSTEL----------------------------------------APPLPV 1843
                  .|:..:|.|:|:|                                        .|.|
  Fly  1910 SLDEAHSPHPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQNGDGDGYSTLQHPMNGLGLPTL-- 1972

Human  1844 RREAKAPPPPPPKARKSGIPTS 1865
                    ||||.|.:|.:|.|
  Fly  1973 --------PPPPSAVESPMPAS 1986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DOCK5	NP_079216.4	SH3_DOCK1_5_A	12..67	CDD:212984	24/54 (44%)
		DOCK_N	75..434	CDD:465040	121/375 (32%)
		C2	442..637	CDD:472691	73/197 (37%)
		DHR2_DOCK5	1238..1637	CDD:212581	174/416 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1679..1702		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1772..1870		43/253 (17%)
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	24/54 (44%)
		DOCK_N	67..406	CDD:465040	122/380 (32%)
		C2_Dock-B	414..600	CDD:176077	73/197 (37%)
		DHR2_DOCK	1215..1610	CDD:471388	174/405 (43%)