Protein Alignment DOCK5 and Zir

DIOPT Version :10

• Sequence 1: NP_079216.4
• Gene: DOCK5 / 80005
• HGNCID: 23476
• Length: 1870
• Species: Homo sapiens
• Sequence 2: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Alignment Length: 2054
• Identity: 364/2054 - (17%)
• Similarity: 658/2054 - (32%)
• Gaps: 746/2054 - (36%)

Human   168 DNGNILDPDETSTIALFKAH--EVASKRIEEKIQEEKSI-----------LQ-NLDLRGQSIFST 218
            |..|.....:...:|||..:  ..|.:.||.::..|..:           || .|:|..:.||::
  Fly   224 DQSNEARRQQDRQMALFSLYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFAS 288

Human   219 IHTYGLYVNFKNFVCNIGEDAELFMALYDPDQSTFISENYLIRWGSNGMPKEIE--------KLN 275
                                    ||:||..:...||||:.....::.:.:.:.        ...
  Fly   289 ------------------------MAIYDAKERQKISENFYFDMNADSLKRMLSSHVQCADISTQ 329

Human   276 NLQAVFTDLS--SMDLIRPRVSLVCQIVRV--GHME------LKEGK---------------KHT 315
            :..|:| ::|  |.||.     ||.::.:|  |.:.      |||.|               :..
  Fly   330 SHSAIF-EISYPSNDLF-----LVIRLEKVLQGDINNSVEPYLKEDKDKYREKVKSNAVDYCERL 388

Human   316 CGLRRPFGVAVMDITDIIHGKVDD-------------------------------EEKQHFIPFQ 349
            ...|.||....:.:|::.:|  |:                               :.|.....|.
  Fly   389 GKYRMPFAWTGIYLTNVFNG--DNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFD 451

Human   350 QIAME------TYIRQRQL-------IMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWV 401
            |:..:      |..|:..|       ..||...::|:....|:|..:......:....|.:.|:.
  Fly   452 QLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYK 516

Human   402 SL-------------KLLPGDL-------TQVQKNF---------SHLVDRSTAIARKMGFPE-- 435
            .|             |.:||.:       .:..||.         ....|....:...:.||:
  Fly   517 ILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNVRPVKEILEFPQSA 581

Human   436 ------------IILP---------GDVRN-DIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGK 478
                        .:.|         |..|| .:.|.|:.||       |||         |....
  Fly   582 IYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGE-------TPK---------DAVNA 630

Human   479 LLEKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRH----RSSQET 539
            :..|:..|....|..    :.|.|..|.|.:|:.:|:::........|:.||..|    :..|:.
  Fly   631 IYGKSSCPKFSTEAF----TAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDL 691

Human   540 RDKSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMEDAKFY---LTLPGTK-MEMEEKEL 600
            :...|...|..::.|:. || .|:.|..:|.|..  ....|:..|.   :.|||.| ::......
  Fly   692 QPSVETPIGYTWLPLLE-DG-KLKFGEFNLPVMV--ESPPENYSFIPPNVHLPGIKWLDNHRAVF 752

Human   601 QASKNLVTFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKK-LMEVDGGE 664
            ..:...||...:.||..|.|   .|||....|:|:..      .....||:..||| |::::...
  Fly   753 SINVEAVTAIHTLDSFLDRF---FLICEYLDTRNIPS------HIGENNIETELKKCLLDIEYAN 808

Human   665 ---IVKFLQDTLDALFNIMM--------EMSDSETYDFLVFDALVFI---ISLIGDIKFQHF--N 713
               :|:.|...||.|..:::        .||...|    ||:.|..:   :|::.|.::..:  .
  Fly   809 REPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGST----VFEVLCLVSSLLSILNDDQYDQYGRQ 869

Human   714 PVLETYIYKHFSATLAY-----------------VKLSKVLNFY---VANADDSSKTELLFAALK 758
            .:|.||:  ||...:.:                 ::||:....|   :|:.....:.||....|.
  Fly   870 SLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLH 932

Human   759 ALK---------------------------------YLFRFIIQSRVLYLR----FYGQSKD--G 784
            ::.                                 :||..|::|.:.:|.    ..|..|.  .
  Fly   933 SMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFP 997

Human   785 DEFNNSIRQL---------------------------FLAFNML--MDRPLEEAVKIKGAALKYL 820
            .:||:.:..|                           |..|::|  |||..     :.|....|.
  Fly   998 HQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGF-----VFGLIKTYT 1057

Human   821 PSIINDVKLVFDPVELSVLFCKFIQS------------------------IPDNQLVRQKLNC-- 859
            ..:|:....:.|.:...:.|.:.:.|                        .|.......:.:|
  Fly  1058 KVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGS 1122

Human   860 MTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHEASSQLLSNILEVLD---------- 914
            :.:.:.:.|.::...:..|:.|:...|:..: :..|...|..:.:.:.|::...|
  Fly  1123 LERALHADLSQEFLQQHFLVGLVLSDLAAVM-EVPNPQLHGKAIRCIRNLMTSHDLDARYSETDA 1186

Human   915 RKDVGATAVHIQLIMERLLRRINRTVIGMNR----------QSPH-------IGSFVACMIALLQ 962
            |..|.|..:.:..|:...:.::::..:..:|          |.||       |...||..|:
  Fly  1187 RARVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAIS--- 1248

Human   963 QMDDSHYSHY---------ISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFL 1018
              ....||:.         :|:..||..::.||                   |::.|:.:|
  Fly  1249 --GSRPYSYLNEQVKNKLPLSSENTRHLLVCFL-------------------WVLKNLERN---- 1288

Human  1019 RAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQ-----LETFSQAKRNKIV----- 1073
                    ||.|:.||.:...:               |:.||     |:||....:..:.
  Fly  1289 --------VLYRWLMDLSPHRV---------------HQMLQGVNVCLKTFEYTGQKNVATLKRT 1330

Human  1074 -----KKYG--DMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPI---F 1128
                 :|.|  |:::::...||      |.:..::  .::....:...|.:...||..:|.   :
  Fly  1331 NTQSFRKTGSTDVKEKLEECIR------GTNSARY--DLINRRKDRNSTEKFRWRKDQMPYRSQY 1387

Human  1129 FDMMQCEFNFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKL-LLEHCRKHKYLSSSGEV 1192
            .|.:       |..     |:||  :|...:||....|...|||:.| ::.|...:.|.:..|.|
  Fly  1388 ADAV-------GKS-----EHEL--ELSHFIEGSLATEVALVLLDTLEIIVHAAANLYHNLLGTV 1438

Human  1193 FALLVSSL--------LENL--------LDYRTIIMQDES------------------------- 1216
            ..:|:.||        |:||        ..:..::..||:
  Fly  1439 LKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQA 1503

Human  1217 --------KEN----------RMSCTVNV------------------------------------ 1227
                    ::|          :|..|:::
  Fly  1504 AASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTS 1568

Human  1228 ---------------------LNFYKE----------------KKREDIYIRYLYKLRDLHRDCE 1255
                                 :..|:|                :...|:.:.:|..:...||:..
  Fly  1569 FPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERA 1633

Human  1256 NYTEAA------------YTLLL----HAELLQWSDKPCVPHLLQKDSY---------------Y 1289
            |:||||            |..:|    |..:...|.:...|:.|.:.:.               .
  Fly  1634 NHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGN 1698

Human  1290 VYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGNLLKKRASFYENI-- 1352
            .:|:..|| .|.:|..:.|....|:|...::.|.|....|:. .|::.|..:..|....:..|
  Fly  1699 HFTETGLK-ALLEEASNSFQVAGMYEAMNEVYKILIPICEAN-RDFQKLSKVHGKLQEAFNRISQ 1761

Human  1353 IKAMRPQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQF-----PNAE---KMT 1409
            ::..|....||.||:||..|.. |..:.|||:.....:..:...||...:     |::.   |.:
  Fly  1762 LQGKRVFGTYFRVGFYGGKFGD-LDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDS 1825

Human  1410 STTPPGEDIKS--SPKQYMQCFTVKPVMSLPPSYKDKPVPEQILNYYRAN-EVQQFRYSRPFRKG 1471
            :|.    ||.|  ..|.|:|...|:|       |.:.........|:..| .:::|.|:.||.|.
  Fly  1826 NTV----DINSLDPDKAYIQITYVEP-------YFETYEMRHRETYFERNFNIKRFIYATPFTKN 1879

Human  1472 EKDPDNEFATMWIERTTYTTAYTFPGILKWFEVKQISTEEI--SPLENAIETMELTNERISNCVQ 1534
            .| ...|.......:|..|||..||.:..  .:..||.::|  .|:|.|||.::.....::....
  Fly  1880 GK-AHGELNEQCKRKTILTTANHFPYVKT--RIMVISRQQIVLEPIEVAIEDIQKKTLELAAATN 1941

Human  1535 QHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQMPL 1599
            |...|..:    |.|:|.|.:...|..|.......|.:.
  Fly  1942 QEPADPKI----LQMVLQGCIGTTVNQGPMEMASVFLSN-------------------------- 1976

Human  1600 LTEGIRI---HGEKLTEQLKPLHERLSSCFRELKEK----VEKHYGVITLPPNLTERKQSRTGSI 1657
            |::|..:   |..||         ||  ||||..::    ::|:..:|.......:|:..|....
  Fly  1977 LSDGTTVPTKHQNKL---------RL--CFREFSKRCADALKKNRNLILSDQKDYQRELERNNDR 2030

Human  1658 VL----PYIMSSTLRRLSITSVTS-SVVSTSSNSSDNAP 1691
            .:    |:|        ::|||.: .||..::.::.:.|
  Fly  2031 FIERLTPFI--------TLTSVQNHGVVKANAYNNKSTP 2061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DOCK5	NP_079216.4	SH3_DOCK1_5_A	12..67	CDD:212984
		DOCK_N	75..434	CDD:465040	63/385 (16%)
		C2	442..637	CDD:472691	50/203 (25%)
		DHR2_DOCK5	1238..1637	CDD:212581	100/451 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1679..1702		3/13 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1772..1870
Zir	NP_608489.2	DOCK_C-D_N	46..153	CDD:463380
		C2_Dock-C	589..769	CDD:176078	45/203 (22%)
		DHR2_DOCK_C	1614..2035	CDD:212568	103/478 (22%)