Protein Alignment IFT56 and Ttc26

DIOPT Version :10

• Sequence 1: NP_079202.2
• Gene: IFT56 / 79989
• HGNCID: 21882
• Length: 554
• Species: Homo sapiens
• Sequence 2: NP_650486.1
• Gene: Ttc26 / 41905
• FlyBaseID: FBgn0038358
• Length: 570
• Species: Drosophila melanogaster
• Alignment Length: 575
• Identity: 301/575 - (52%)
• Similarity: 406/575 - (70%)
• Gaps: 41/575 - (7%)

Human     1 MMLSRAK------------PAVGRGVQHTDKRKKKGRKIP---KLEELLSKRDFTGAITLLEFKR 50
            |:|||.|            |..|.||      .::.||.|   .||:.:.:||:|||...|||..
  Fly     1 MILSRGKTDSASSRNASGGPGSGLGV------GRQARKTPAPASLEDFIIRRDYTGARAFLEFAN 59

Human    51 HVGEEEE--------DTNLWIGYCAFHLGDYKRALEEYENATKEENC-NSEVWVNLACTYFFLGM 106
            ...:|||        ..:.||.:|.||||||::||.:|:...:..:. :.::.:|||...|:||:
  Fly    60 DDEDEEEGAHGSKQSQVDQWIAFCNFHLGDYQQALAQYKAIQQGSSTPDGKLDLNLAVCMFYLGL 124

Human   107 YKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVT--EDQLSLASIHYMRSHYQE 169
            |::|:.....|:.:.|:.|||||||||..:|::.....:.|||.:  |.||||||:||||:||||
  Fly   125 YEEAQQLMANAADNPLKQRLLFHLAHKLGNEEEWSQLQEELQDSSSLEQQLSLASMHYMRAHYQE 189

Human   170 AIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYN 234
            |||:|||:|:||:||.|:|||:|||:|||||||:|||||.|||.|..|||||:||||||.|||:|
  Fly   190 AIDVYKRVLVDNKEYQAINVYLALCFYKLDYYDMSQEVLDVYLSQHGDSTIAINLKACNRFRLFN 254

Human   235 GRAAEAELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQD 299
            ||.||.|:|::.||.:    |..:|:||||||||.|||||:|||.|:::||||||||.||||:|.
  Fly   255 GRVAEQEIKNIADNGT----FGADLLRHNLVVFRNGEGALRVLPGLLNIIPEARLNLAIYYLKQG 315

Human   300 DVQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIPGRQC 364
            |||||:.|:|:|:||:|.||||||||:|||||::||::|:|.|||...|||.||:|||||||||.
  Fly   316 DVQEAHALMKELQPTSPHEYILKGVVHAALGQQLGSKEHIKTAQQNLHLVGSSATECDTIPGRQS 380

Human   365 MASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQSEKMKNDYI 429
            |||.|||.:||::||:|:||.:|||.|||:||:|:||||.|||...|.||..:.|....:||.:.
  Fly   381 MASAFFLYEQFEEVLVYMNSIRSYFVNDDVFNYNFAQAKCATGYYKEAEELLMQISDMDIKNQHT 445

Human   430 YLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYSAKAFDVLERLDPNP 494
            |...||:|:|....|.|||.:::..:|:.|:|.|||||||:|||..:|:.:|||||:||:|||:|
  Fly   446 YCMILAKCHIHCGHPELAWNVFITRDTNAEAFILLQLIANECYKCAEFWVAAKAFDMLEKLDPSP 510

Human   495 EYWEGKRGACVGIFQMIIA----GREPKETLREVLHLLRSTGNTQVEYMIRIMKK 545
            |.||||||||.|:...:..    || |...:.||:.:||.:.|:|.|.||:.::|
  Fly   511 ENWEGKRGACAGVLFALCTKAQRGR-PGGGISEVIGILRDSSNSQAEAMIKTIRK 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IFT56	NP_079202.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		9/34 (26%)
		LapB	29..224	CDD:442196	102/205 (50%)
		TPR 1	57..90		13/41 (32%)
		TPR repeat	58..86	CDD:276809	12/27 (44%)
		TPR 2	92..125		10/32 (31%)
		TPR repeat	139..178	CDD:276809	24/40 (60%)
		TPR 3	151..184		24/34 (71%)
		LapB	157..>331	CDD:442196	122/173 (71%)
		TPR repeat	184..214	CDD:276809	23/29 (79%)
		TPR repeat	219..247	CDD:276809	19/27 (70%)
		TPR 4	468..501		21/32 (66%)
Ttc26	NP_650486.1	LapB	<85..244	CDD:442196	86/158 (54%)
		TPR repeat	107..133	CDD:276808	8/25 (32%)
		BepA	<301..360	CDD:443813	41/58 (71%)