Protein Alignment FRMD1 and zgc:172136

DIOPT Version :10

• Sequence 1: XP_011534439.1
• Gene: FRMD1 / 79981
• HGNCID: 21240
• Length: 614
• Species: Homo sapiens
• Sequence 2: XP_009305755.1
• Gene: zgc:172136 / 566376
• ZFINID: ZDB-GENE-030131-1008
• Length: 553
• Species: Danio rerio
• Alignment Length: 586
• Identity: 249/586 - (42%)
• Similarity: 347/586 - (59%)
• Gaps: 92/586 - (15%)

Human    88 MDAMASEHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDL 152
            |.....:.|.|.||||::|.|.:.|||||||:::|.:||.:..:|:..:|||.:|:|||:||:||
Zfish     1 MSVPTKQERTVCVLLPNKETLDITVGVKATGQDVFHRVCELLGVRELHYFGLTLVKNNEHIFLDL 65

Human   153 EQKLSKYFSKDWKKER-NEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQ 216
            |:||:|||.|:||::. .:|:.:...|.:..|:||:||||||:|.:.:||.|||..|:||||||:
Zfish    66 EEKLAKYFPKEWKQDSGKQGSHRRSIPPLLCLKVQYYVENGRLICERKARKLYYYDLRERVLRSE 130

Human   217 CAHREEAYFLLAACALQADLGEH----RESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHR 277
            |..:||.||.||..|||||..:|    :...|| .||:|..|||.|||.||||||:|.|.|.:|:
Zfish   131 CRQQEEVYFQLAGFALQADHSDHSSEGQSHGHA-MYFQPKEYFPPWIIAKRGIDYLLCHGPKVHK 194

Human   278 ERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQEVDRAPQLLY 342
            |..|:|.::|:|.||:|:||||||||.|:||.|||||.:.:.:|||.|||:.::|||:....|||
Zfish   195 ELWGMSCRDAVLLFIRESCRLEDVPVTFYRLQKDKKEEKGSALLGLTLRGMQVFQEVNNVRDLLY 259

Human   343 DLPWPHVGKLAFLGKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLR 407
            |.||.|||:|.|||||.|||.||||:|:|||||||..:||||||..|.:.|:|:|.::|.|:.||
Zfish   260 DFPWFHVGRLTFLGKKFEIQPDGLPSARKLVYYTGSAFRSRHLLLHLSSCHRLYLSLQPALKHLR 324

Human   408 QREEAEEKQHYRESYISDELELDLASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWL 472
            |.||.|||:.||||||||||:||..         .|:..|. |||||..|      |||:|
Zfish   325 QLEETEEKKRYRESYISDELDLDQP---------CSEGSPR-LSRHSTSS------SGIEA---- 369

Human   473 RESREMSVDVPLEVHGLHEKEPSS--SPRTSRSHPSTRGDSQATRQEP----------------- 518
             ::|:.||.|  |:..:.|||.||  :..|::||.....::.:  |||
Zfish   370 -DTRQNSVSV--EMVSVEEKEKSSINTSSTAQSHEEHWQETDS--QEPGEVSVDDPVDLLRLAEL 429

Human   519 -------CTQVRTRGQSAEAVHQIQEMTAGVSEEQ-----------------------HSHGLDD 553
                   |..:::...|.:     |.|::...::|                       ::..|:|
Zfish   430 LEGVSVDCPTIQSVKDSKD-----QHMSSVTGKDQTDLSDPDGLKQVLNQKLSNPSDCYNLSLED 489

Human   554 M-QLHQLALHPAPT----SLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFV 613
            : ||..|.....||    |:.:||  ||......||....:|..:|.:|||:|....:..|.|.|
Zfish   490 VRQLSPLLPLGTPTAPNASIGYTF--ALPHSPTNPCPDDTSLCVQRPTNCLSLARLDDNQPLELV 552

Human   614 V 614
            :
Zfish   553 L 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD1	XP_011534439.1	FERM_F1_FRMD1	95..192	CDD:340717	47/97 (48%)
		FERM_M	190..306	CDD:459788	67/119 (56%)
		FERM_C_FRMD1_FRMD6	299..407	CDD:270006	64/107 (60%)
zgc:172136	XP_009305755.1	Ubl1_cv_Nsp3_N-like	8..106	CDD:475130	47/97 (48%)
		B41	13..223	CDD:214604	111/210 (53%)
		FERM_C_FRMD1_FRMD6	216..324	CDD:270006	64/107 (60%)