Protein Alignment FRMD1 and frmd6

DIOPT Version :10

• Sequence 1: XP_011534439.1
• Gene: FRMD1 / 79981
• HGNCID: 21240
• Length: 614
• Species: Homo sapiens
• Sequence 2: XP_012824779.1
• Gene: frmd6 / 548781
• XenbaseID: XB-GENE-977939
• Length: 610
• Species: Xenopus tropicalis
• Alignment Length: 603
• Identity: 258/603 - (42%)
• Similarity: 355/603 - (58%)
• Gaps: 88/603 - (14%)

Human    94 EHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSK 158
            :.|.|.|.||:.:.|.:.:.|||..:||.:|||::..:||...|||.|::|||:::|:|.|||.|
 Frog    14 DRRSVCVFLPNDDTLNIIINVKALCQELLEQVCDLLHLRDCHLFGLSVIQNNEHVYMELSQKLYK 78

Human   159 YFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEA 223
            |..|:||||.::|.::...|.:...|||:||||||:|||..||:.|||||:::||.|||..||||
 Frog    79 YCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRTARYYYYCHLRKQVLHSQCMQREEA 143

Human   224 YFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAM 288
            ||||||.|||||||..:.:.|.|:||||.:|||.|:|.|||.||||:|:|.:||::..|:..||.
 Frog   144 YFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVIKKRGKDYILKHIPNIHRDQFALTVSEAH 208

Human   289 LCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQEVDRAPQLLYDLPWPHVGKLA 353
            |.:|:||.||:||.||:::|:|||||...:::|||.|||:.|:|..|...|||||.||.:||||.
 Frog   209 LMYIKEAARLDDVAVHYYKLYKDKKEMEASLMLGLTLRGIQIFQSSDDEKQLLYDFPWTNVGKLV 273

Human   354 FLGKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHY 418
            |:|||.||..||||:|:||:|||||:.||||||.||..||:|::.::|.|:|:|:.||.|||:.|
 Frog   274 FVGKKFEILPDGLPSARKLIYYTGCSVRSRHLLQLLSNSHRLYMNLQPVLRQVRKLEEHEEKKQY 338

Human   419 RESYISDELELDL-----ASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREM 478
            |||||||.|:.|:     .||:...|..|.:|  ..|||||..||.||:||||:|::   :.|::
 Frog   339 RESYISDTLDQDMDQLEKRSRASGSSAGSVKH--KRLSRHSTASHSSSHTSGIEADT---KHRDI 398

Human   479 SVDVPLEVHGLHEKEPSSSPRTSRSHPSTRG-----------DSQ-------------------- 512
            ..:.......||.|..:.|..||.|...|.|           |||
 Frog   399 GPEDSFSGTSLHRKLKTCSSMTSNSSSHTSGAESAGKDRLEDDSQEDEIEMLVDDPKDLDLPLDI 463

Human   513 -------------------------------ATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQ 546
                                           :|.....|.|:.||||.:::.|........|.::
 Frog   464 SPDLCIYITEDMLVSQQLNGHSGLVVKEVNSSTSSSSETVVKLRGQSIDSIPQTACRKPKTSTDR 528

Human   547 HSHGLDDMQLH-----QLALHPAPTSLSHTF-------HRALDCR--LAGPC-ETRATLPSKRSS 596
            ||..|||::|:     |:|.....|:.|:||       .|.|.|.  ||..| ..:..|.||::|
 Frog   529 HSLSLDDIRLYQKDFLQIAGLNQETAQSYTFGCGHDLHERGLYCNGCLAQQCINIKEPLSSKKAS 593

Human   597 NCLALDLFGEAPPQEFVV 614
            ...:|||..:..| ||||
 Frog   594 KYFSLDLTHDDFP-EFVV 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD1	XP_011534439.1	FERM_F1_FRMD1	95..192	CDD:340717	43/96 (45%)
		FERM_M	190..306	CDD:459788	71/115 (62%)
		FERM_C_FRMD1_FRMD6	299..407	CDD:270006	62/107 (58%)
frmd6	XP_012824779.1	FERM_F1_FRMD6	15..112	CDD:340718	43/96 (45%)
		B41	20..226	CDD:214604	111/205 (54%)
		FERM_C_FRMD1_FRMD6	219..327	CDD:270006	62/107 (58%)