Protein Alignment FRMD1 and ex

DIOPT Version :10

• Sequence 1: XP_011534439.1
• Gene: FRMD1 / 79981
• HGNCID: 21240
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_476840.2
• Gene: ex / 33218
• FlyBaseID: FBgn0004583
• Length: 1427
• Species: Drosophila melanogaster
• Alignment Length: 656
• Identity: 157/656 - (23%)
• Similarity: 247/656 - (37%)
• Gaps: 152/656 - (23%)

Human    76 RPACSQQEPTLGMDAMASEH-----RDVLVLLPSREQ---LRLAVGVKATGRELFQQVC---NVA 129
            |..|:...| |.:.|.::|.     |.:.:.|..::|   |...|..|:..||::.|.|   ...
  Fly     2 RAFCTVSAP-LEVCASSAEQLSPGSRFLALRLLGQQQPKTLYFLVDAKSRVREVYTQTCLHFATQ 65

Human   130 SIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPRAPFVAF-LRVQHYVENGR 193
            .:.|.:.|||.|:.:.||:|.|.|.|||||..|.|:.....|.:....|.:.. .|||.|:|:..
  Fly    66 GMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSSHTHGLDANGRPLLELHFRVQFYIESPF 130

Human   194 VISDHRARHLYYCHLKERVLRSQCAHR--EEAYFLLAACALQADLGE----------------HR 240
            ::.|..:||.||..|:..:|:......  |:|...||..|||||||:                ..
  Fly   131 MLKDETSRHNYYLQLRHNILQRDLPREQAEQALVFLAGLALQADLGDAPPGTSNSKDDSGEETSA 195

Human   241 ESAHAGRYFEPHSYFPQWIITKRGIDYILR----------------------------------- 270
            ..::.||.....:..|:  |:||..:.:||
  Fly   196 SPSNGGRGLSATTTLPK--ISKRANERMLRLSTYVASTSKRETIPLPPSLPPNGADYYRIEDYLP 258

Human   271 ---HMP-------TLHRERQGLSPKEAMLCFIQEACRL-EDVPVHFFRLHKDKKE-GRPTVILGL 323
               |.|       ..|||..|::..||.|.:||:||.| |.:..|.:|:...|.| |..:....:
  Fly   259 SGLHTPWARSAMRACHREHLGMATAEAELLYIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVV 323

Human   324 ALRGVHIY----QEVDRAPQLLYDLPWPHVGKLAFLGKKLEIQLDGLPAAQKLVYYTGCTWRSRH 384
            ..:|:.|.    ......|:....| ||::.||:|..||.||:    ....::..|.....:::.
  Fly   324 YAKGIKILGGESTNSSSNPETTTFL-WPNITKLSFERKKFEIR----SGESRITLYAASDEKNKL 383

Human   385 LLHLLRASHQLHLRVRPTLQQL--RQREEAEEKQHYRESY-ISDELELDLASRSFPGSGVSSQHC 446
            ||.|.:.:||..:::...|:::  |:.|||.|.|....|| .|..|.|...|::.....|.|
  Fly   384 LLTLCKDTHQWSMKLAARLKEVSKREEEEAAESQRLHASYACSRSLLLPYKSKNEQRISVIS--- 445

Human   447 PHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSSS----------PRTS 501
                      |..|:.||||.::   |...|..:::.:.........||:.          |..|
  Fly   446 ----------STSSNTTSGIVSD---RVHSEDELEIMINTPPAPLAAPSTESLALAHLLDRPSVS 497

Human   502 RSHPSTRGDSQATRQEPCTQVRTRGQSAEA-------VHQIQEMTAGVSEEQHSHGLDDMQLHQL 559
            |...|....|....:|....:..|.|.|.:       ...:|..:.|.:....|...|...
  Fly   498 RQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATIVTNSSVQRNSMGTTANDSSTATDSPS---- 558

Human   560 ALHPAPTSLSHTFHRALDCRL---------AGPCETRATLPSKRSSNCLAL--------DLFGEA 607
            :.|...:..|.|      |..         ||...:.|.:|...:|:.|.|        ....|.
  Fly   559 SQHNIGSQCSST------CSTVVVTSPVNGAGASSSGAPIPVHSTSSSLELGFSHTAQNSALSET 617

Human   608 PPQEFV 613
            .|.:|:
  Fly   618 SPDDFL 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD1	XP_011534439.1	FERM_F1_FRMD1	95..192	CDD:340717	34/108 (31%)
		FERM_M	190..306	CDD:459788	43/179 (24%)
		FERM_C_FRMD1_FRMD6	299..407	CDD:270006	26/114 (23%)
ex	NP_476840.2	FERM_F1_PTPN13_like	25..128	CDD:340621	33/102 (32%)
		B41	27..297	CDD:214604	72/271 (27%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	26/111 (23%)
		PHA03255	512..>681	CDD:165513	22/122 (18%)