Protein Alignment FRMD1 and Frmd6

DIOPT Version :10

• Sequence 1: XP_011534439.1
• Gene: FRMD1 / 79981
• HGNCID: 21240
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_082403.2
• Gene: Frmd6 / 319710
• MGIID: 2442579
• Length: 622
• Species: Mus musculus
• Alignment Length: 614
• Identity: 249/614 - (40%)
• Similarity: 350/614 - (57%)
• Gaps: 98/614 - (15%)

Human    94 EHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSK 158
            :.|.|.:.||:.:.:.:.:.||....:|..|||::..::|:..|||.|::|||:::|:|.|||.|
Mouse    14 DRRRVCIFLPNDKSVSIIINVKILCHQLLVQVCDLLRLKDSHLFGLSVIQNNEHVYMELSQKLYK 78

Human   159 YFSKDWKKERNE--------GNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRS 215
            |..|:||||.::        |.::...|.:...|||:|||||::|||..||:.||.||:::||.|
Mouse    79 YCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHS 143

Human   216 QCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQ 280
            ||..||||||||||.|||||||..:...|.|.||||.:|||.|:::|||.||||:|:|.:|:::.
Mouse   144 QCVLREEAYFLLAAFALQADLGNFKRKLHHGDYFEPEAYFPAWVVSKRGKDYILKHIPNMHKDQF 208

Human   281 GLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQEVDRAPQLLYDLP 345
            .|:..||.|.:|:||.||:||.:|::||:|||:|...::.|||.:||:.|:|.::...|||||.|
Mouse   209 ALTASEAYLKYIKEAVRLDDVAIHYYRLYKDKREAEGSLTLGLTMRGIQIFQNLEEEKQLLYDFP 273

Human   346 WPHVGKLAFLGKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQRE 410
            |.:||||.|:|||.||..||||:|:||||||||..||||||.||..||:|::.::|.|:.||::|
Mouse   274 WTNVGKLVFVGKKFEILPDGLPSARKLVYYTGCPTRSRHLLQLLSNSHRLYMNLQPVLRHLRKQE 338

Human   411 EAEEKQHYRESYISDELELDL-----ASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANS 470
            |.|||:.||||||||.|:||:     .||:...|..|.:|  ..|||||..||.||:||||:|::
Mouse   339 ENEEKKQYRESYISDNLDLDMDPLEKRSRASGSSAGSVKH--KRLSRHSTASHSSSHTSGIEADT 401

Human   471 WLR------------------------------------------------ESREMSVDVPLEVH 487
            ..|                                                |..||.||.|.::.
Mouse   402 KPRDPGPEDSCSGSAMHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDSQDEEIEMLVDDPRDLE 466

Human   488 GLHEKEPSSSP-------------RTSRSHP----STRGDSQATRQEPCTQVRTRGQSAEAVHQI 535
            .:.|:....||             |....|.    ...|.|.::..|  |.||.||||.:::.|.
Mouse   467 PMPEESLEVSPEMCIYITEDMLLSRKLNGHSGLIVKEIGSSTSSSSE--TVVRLRGQSTDSLPQT 529

Human   536 QEMTAGVSEEQHSHGLDDMQLHQ-----LALHPAPTSLSHTF-------HRALDCR--LAGPC-E 585
            .......|.::||..|||::|:|     :|.....|:.|:||       ...|.|.  ||..| .
Mouse   530 ICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDESGLYCNSCLAQQCVN 594

Human   586 TRATLPSKRSSNCLALDLFGEAPPQEFVV 614
            .:...|.||:|...:|||..:..| ||||
Mouse   595 IQDAFPVKRASKYFSLDLTHDEVP-EFVV 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD1	XP_011534439.1	FERM_F1_FRMD1	95..192	CDD:340717	38/104 (37%)
		FERM_M	190..306	CDD:459788	66/115 (57%)
		FERM_C_FRMD1_FRMD6	299..407	CDD:270006	59/107 (55%)
Frmd6	NP_082403.2	Ubl1_cv_Nsp3_N-like	15..120	CDD:475130	38/104 (37%)
		FERM_M	118..234	CDD:459788	66/115 (57%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	59/107 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..452		22/96 (23%)