Protein Alignment FRMD1 and frm-7

DIOPT Version :10

• Sequence 1: XP_011534439.1
• Gene: FRMD1 / 79981
• HGNCID: 21240
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_506085.2
• Gene: frm-7 / 179687
• WormBaseID: WBGene00001493
• Length: 947
• Species: Caenorhabditis elegans
• Alignment Length: 641
• Identity: 151/641 - (23%)
• Similarity: 243/641 - (37%)
• Gaps: 139/641 - (21%)

Human    16 TPGLSHEEIWAVVSSSSRPLPVHCPALTSRTW-QASLFHHEQASREDKTFRGARCMEPSPERPAC 79
            :||.:..::      :|| ||||....:|.:: ...:|......|..:||
 Worm     3 SPGSARGDV------TSR-LPVHLQQPSSSSFSDPEVFTSTHNIRPGQTF--------------- 45

Human    80 SQQEPTLGMDAMASEHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVR- 143
                              |.|...::|...:|:..|....::..:.....|:.|.:.|||...:
 Worm    46 ------------------VSVQTLTKESFHVAISSKTKVHDVLWKCGERLSLSDDKLFGLAFRQP 92

Human   144 ---------NNEYIFMDLEQKLSKYFSK-----DWKKERNEGNEKPRAPFVAFLRVQHYVENGRV 194
                     .:||.|:|...|:.||..|     :|..:.:|.    |...|.:.||:.|::...:
 Worm    93 TEGIGGDQPRHEYYFLDPAAKIMKYAQKQPRFANWHSKSSEN----RPILVLYFRVRVYIDQVGL 153

Human   195 ISDHRARHLYYCHLKERVLRSQCAHR---EEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFP 256
            :|..:||..||..||:..|.......   ||..:.:||.||..|.|    :.:.| ||....|||
 Worm   154 LSCPKAREHYYLQLKDNFLDHWAGRNSVSEERCWYMAALALITDKG----NDYLG-YFRAEQYFP 213

Human   257 QWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEACRLE-DVPVHFFRLHKDKKEGRPTVI 320
            .|:|.:||::||..::|....:.......:||..|:.||.|.. .:..|.:.|.:.|.:.....:
 Worm   214 LWVINERGLEYIRNNLPAACEDIINEGRYKAMEKFMIEAGRSPFALNCHLYGLRRHKMDNTDNAV 278

Human   321 LGLALRGVH---IYQEVDRAPQLLYDLPWPHVGKLAFLGKKLE-IQLDGLPAAQKLVYYTGCTWR 381
            ||:..:|:.   |.::.||.|  |..|.|..|.||:|..||:. |..||    .|:..|.....:
 Worm   279 LGINAKGIEMCDIGEDGDRIP--LRSLSWSRVAKLSFNRKKMTIIGSDG----TKMSLYAQTEHK 337

Human   382 SRHLLHLLRASHQ-------LHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDLASRSFPGS 439
            :::||.|.:|.||       ||..:.|.                .:.|:  |:.:|..|.| ..|
 Worm   338 AKYLLELCKAVHQTLLVMSHLHATMAPP----------------PKPYL--EMSVDGISTS-STS 383

Human   440 GVSSQHCPHCLSRHSADSHGSSYTSG------IKANSWLRESREMSVDVPLEV----HGLHEKEP 494
            |:.|       ..|..||...|...|      :.:...||...:.::||.:|.    |...|:..
 Worm   384 GIGS-------GDHDKDSDSLSSACGDRCHGSMSSKLRLRIKMDSNLDVKIEKMELDHIRQERAA 441

Human   495 SSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVS---------EEQHSHG 550
            |.|.:.|.....:|.:.:.....|..::.....|...|...|:.....|         |...|..
 Worm   442 SQSSKASDESERSRLEVRHQTYHPAHELSGATSSTYTVTTAQDTATRPSSMDNASQTIESGSSRS 506

Human   551 LDDMQLH--QLALHPAPTSLS--HTFHRALDCRLAGPCETRATLPSKRSSNCLALD 602
            :.|:..:  ....|.:.||.|  |....:.|.  ..|.||  .:.|...|..:.||
 Worm   507 IVDVNFNNKNRERHESSTSTSGTHVLFSSKDA--TPPIET--AVVSSTMSMSVPLD 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD1	XP_011534439.1	FERM_F1_FRMD1	95..192	CDD:340717	25/111 (23%)
		FERM_M	190..306	CDD:459788	36/119 (30%)
		FERM_C_FRMD1_FRMD6	299..407	CDD:270006	33/119 (28%)
frm-7	NP_506085.2	B41	45..269	CDD:214604	63/265 (24%)
		FERM_C_FRMD1_FRMD6	257..362	CDD:270006	32/110 (29%)