Protein Alignment JADE1 and Br140

DIOPT Version :10

• Sequence 1: XP_024309986.1
• Gene: JADE1 / 79960
• HGNCID: 30027
• Length: 857
• Species: Homo sapiens
• Sequence 2: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Alignment Length: 919
• Identity: 246/919 - (26%)
• Similarity: 382/919 - (41%)
• Gaps: 213/919 - (23%)

Human    25 SEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTD-LITAMKLHDSYQLNPDEYYVL- 87
            |..|...||.|   ..::|......|...:.:.:.:..|..| ....:.:.|:..|..||.:..
  Fly    98 SSASAGGGSAS---GVSARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAAL 159

Human    88 --------AD--------PWRQEWEKGVQVPVS----------PGTIPQPVARVVSEEKSLMFIR 126
                    ||        ||.:     |||||:          ....|:|:|.....||||
  Fly   160 VARGCILNADAPPLEENAPWAR-----VQVPVARVAEIPDYRVSDAPPRPLAYYRFIEKSL---- 215

Human   127 PKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLE 191
                        .||         |....||:::.|:||||..|||.:.:|:..:...|||.:::
  Fly   216 ------------EEL---------DGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMD 259

Human   192 EFEQRCYDNMNHAIETEEG--LGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILK 254
            ..|:.     :|......|  .|:|.|:|.||.:|...:.::.|.::|||.||:.|||.|||:..
  Fly   260 RLEKE-----SHFQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPY 319

Human   255 VPEGSWLCRTCALGVQP--KCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITK 317
            :|||.||||.|......  .|:|||..|||.|.|..| :|.||.||||||||...:...:|||..
  Fly   320 IPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPIDS 383

Human   318 VSHIPSSRWALVCSLCNEK-FGASIQCSVKNCRTAFHVTCAFDRGL--EMKTIL-AEND---EVK 375
            :..||.:||.|.|.:|.|| .||.|||...:|..|||||||...||  .|.|:. ..||   .|:
  Fly   384 IETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQ 448

Human   376 FKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQL-- 438
            ..:||..|:    |.:     |..:...|:         |.......:||.:...:|:....:
  Fly   449 KFAYCHAHT----PAD-----AKLKMNVPD---------FEDTRHKMKEARKALAKKRSTAPVVL 495

Human   439 -----EDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDN--LAKR- 495
                 .|.......::.:.|    .:|.:|.:..||.|||......||:...:.:.:|  :.:|
  Fly   496 IPTIPPDRVQEIATMVTMQR----KKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRN 556

Human   496 ------EQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERV 554
                  :...|:|:|:.:..|||||||.|.|..:|.:|||:|.:..::.|::..|....||
  Fly   557 GIEGSPDTGELYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLE---- 617

Human   555 SGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSP 619
                     ::|..:|         ||.:..|   ....||:.:.||.|     |...|
  Fly   618 ---------AALNKLL---------DALEARD---SMQIFREPVDTSEV-----PDYTD------ 650

Human   620 GSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLI 684
                  ::|||...|.....:....:..||:..|:..|:.   :|.:..    ..:|..|:...|
  Fly   651 ------IVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMI---QNCLAY----NNKDTVFYRAGI 702

Human   685 KGDLKDKS---FKQSHKPLRSTDV---SQR-HLDNTRAATSPGVG--QSAPGTRKEIVPKCNGSL 740
            :  ::|::   |.|..|.|:...:   ||| |:|:..|.....:.  .:||.: :.||.|.   |
  Fly   703 R--MRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEAEVEQELRLLLAAPAS-EGIVQKL---L 761

Human   741 IKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACH-QHSDYPYLG----LGRVP 800
            |..:.:| .:|.||.....:|.   .|:.....|:...:|...|.| .|::.....    ||..|
  Fly   762 ILADKSQ-VLKNPTYRTKKIKQ---IRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSP 822

Human   801 AKERAKSKLKSDNEND--GYVPDVEMSDSESEA-------------------SEKKCIHTSST-- 842
            :|:|.:.:..|...:.  |:..|.|..||:.::                   |..|.::.||:
  Fly   823 SKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPV 887

Human   843 -ISRRTDII 850
             |:|||.|:
  Fly   888 GINRRTAIL 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JADE1	XP_024309986.1	COG5141	114..>544	CDD:227470	145/456 (32%)
		ePHD_JADE1	270..387	CDD:277174	56/125 (45%)
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	152/496 (31%)
		Bromo_brd1_like	615..712	CDD:99944	27/147 (18%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110
		PWWP_BRPF	1303..1414	CDD:438964