Protein Alignment NOL10 and l(2)34Fd

DIOPT Version :10

• Sequence 1: NP_079170.2
• Gene: NOL10 / 79954
• HGNCID: 25862
• Length: 688
• Species: Homo sapiens
• Sequence 2: NP_609711.1
• Gene: l(2)34Fd / 34839
• FlyBaseID: FBgn0261535
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 721
• Identity: 321/721 - (44%)
• Similarity: 472/721 - (65%)
• Gaps: 50/721 - (6%)

Human     1 MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQ 65
            |.|:.:|:||||:||.|||:|:||:||:||:...|.||.||:|||||||:||.|||:|::|.|.|
  Fly     1 MFVNEVNDVKIYNLSAGKSVPDWLTDRRKRSQLMKKVDSRRQIELIQDFDMPGVCTSIRMSPDQQ 65

Human    66 YILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYK 130
            ||||||||||||:|::...||:|||||.|:||.|||::||||||:|||..|||:|.|:..|.:|:
  Fly    66 YILATGTYKPRVKCFEVSNLSIKFERCFDAEVTTFEVISDDYSKMVFLQCDRYVEIHAAHGRHYR 130

Human   131 TRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGT 195
            .|||:||||..||.||||::.||...:::|||||:|::|.|.:||.:..|.|::|..|.|...||
  Fly   131 LRIPRFGRDMKYHKPSCDMFIVGVGRDIFRLNLERGQFLQPFETDGSCLNACEVNPEHHLLVAGT 195

Human   196 IEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRS 260
            .||.||.|||||:.|...||.|:..    ..:...|:::||||...|.|.|||.:|.||:||:|:
  Fly   196 KEGTVEAWDPRTKQRCSTLDVAMKL----PGVKEFPSVTALKFRNGLHMGVGTASGHVLIYDIRA 256

Human   261 DKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSG 325
            .:|||||:|...||||.:.|..:.:.:.|.|...:|:|::.:||....:|.....||.|..|::|
  Fly   257 KQPLLVKNHLNRLPIKRLAFNPAQNAVYSLDEATLKLWDEQTGKQIAYVESTSSFNDFCTIPDTG 321

Human   326 MLLTANETPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLI 390
            |...|.|..||..||:|.:||||||||||||||||:|......|||||:|||.|:|..||:.||:
  Fly   322 MFFVAQEDVKMMTYYVPAMGPAPRWCSFLDNLTEEIESEVVENVYDDYQFVTAKELAELGMEHLV 386

Human   391 GSPFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLK-KLPKVNKELA 454
            ||..|:.||||:|||.|||:|.|.:|.|||::.:|||||||:||..|..|:|:: ||||||||||
  Fly   387 GSNLLKGYMHGYFMDARLYNKAKAVVEPFAFDRFRKDKIRQEIESERKSRLQIESKLPKVNKELA 451

Human   455 LKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKK 519
            ||:::|:.....|.   |.:::|::|.|.|||.||||.||:|::.:||:|||.|:::::.:.:.|
  Fly   452 LKIMDEQANPSNSA---KQRNVPSLLEDSRFKAMFENADFEVNKSAEEYRLLAPVLNRLDKSKAK 513

Human   520 KLRL---------LEQQELREKEEEEEPEG----KPSDAESSESSDDEKAWVEEVRKQ--RRLLQ 569
            :|:.         |...|.:::||.:..|.    :.||.|:.:.|.||.:..::.|::  :.:.|
  Fly   514 ELKKRVEVAHVAELHADEAQQREESDNDEDLFGFEKSDGETKDDSGDEASSDDDDRREYVKEMKQ 578

Human   570 QEEKVKRQ----ERLKEDQQ-------TVLKPQF-----YEIKAGEEF------RSFKDSATKQK 612
            ..::||||    |.|::|:|       |..:||.     .....|..|      :....|..:|:
  Fly   579 AYKQVKRQREEEEELEDDEQQPDEISDTAKRPQTNGHSQQPTTNGNRFTMTPLDQHQGSSLLQQR 643

Human   613 LMNKTLEDRLKIEAK-NGTLSVSDTTVGSKQLTFTL---KRSEQQKKQQEAE-KLHRQERKRLRR 672
            :...:|:||:::.:: .|.::....::|::|:||.:   |:|:...|::||| |.||:||:.:.|
  Fly   644 IKKASLQDRVRVMSQLEGQVTNVGRSLGNRQMTFEVNKQKKSQFHAKKREAEMKKHREERRSIVR 708

Human   673 SAGHLK 678
            ....|:
  Fly   709 PIKSLR 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NOL10	NP_079170.2	WD 1	44..82		28/37 (76%)
		WD40 repeat	55..95	CDD:293791	26/39 (67%)
		WD 2	88..124		25/35 (71%)
		WD40 repeat	108..153	CDD:293791	25/44 (57%)
		WD 3	127..163		18/35 (51%)
		WD 4	170..205		15/34 (44%)
		WD40 repeat	180..215	CDD:293791	17/34 (50%)
		WD40	<190..330	CDD:441893	56/139 (40%)
		WD 5	219..258		14/38 (37%)
		WD40 repeat	233..267	CDD:293791	18/33 (55%)
		WD 6	262..300		15/37 (41%)
		WD40 repeat	275..311	CDD:293791	9/35 (26%)
		WD 7	304..341		13/36 (36%)
		PTZ00121	<407..>668	CDD:173412	103/303 (34%)
		NUC153	482..508	CDD:462385	16/25 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..557		9/31 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..688		14/38 (37%)
l(2)34Fd	NP_609711.1	WD40	<56..214	CDD:475233	89/157 (57%)
		WD40	<150..303	CDD:441893	65/156 (42%)
		WD40 repeat	179..215	CDD:293791	17/35 (49%)
		WD40 repeat	230..264	CDD:293791	19/33 (58%)
		WD40 repeat	271..305	CDD:293791	9/33 (27%)
		BTV_NS2	<396..584	CDD:282383	75/190 (39%)
		NUC153	476..503	CDD:462385	16/26 (62%)