DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8B and COQ8

DIOPT Version :9

Sequence 1:	NP_079152.3	Gene:	COQ8B / 79934	HGNCID:	19041	Length:	544	Species:	Homo sapiens
Sequence 2:	NP_011396.1	Gene:	COQ8 / 852758	SGDID:	S000003087	Length:	501	Species:	Saccharomyces cerevisiae

Alignment Length:	468	Identity:	193/468 - (41%)
Similarity:	276/468 - (58%)	Gaps:	25/468 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    55 GEEDIRRAREARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGV----LAEMAKKSM 115
            |||::.|..|...:        |..:...||.||||||.::|.||.|:|:..    ::|:||
Yeast    49 GEENVERKHEEEKK--------DTLKSSSVPTSRISRLFHYGSLAAGVGMNAAAKGISEVAK--- 102

Human   116 PGGRLQSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVR 180
                    |.|....|..||::|.:||......:||.|||:||:||.||...:..:|..|..||:
Yeast   103 --------GNSPTWKSLILSDSNIDRITNKFSKMRGVALKIGQLLSFQDEKVLPKELYEILSRVQ 159

Human   181 QSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQ 245
            .||:.||:.|:.:|:.:|||.:|:.|.:..:::|.|||||||||...|..|..|.|||||||:.:
Yeast   160 NSANHMPQRQLEKVMAKELGANWKTKFSKFDKIPMAAASIGQVHAAELPSGQRVVVKIQYPGVKE 224

Human   246 SIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVP 310
            ||.||:.:||.:|..|:.||.|||.::::...:.||.|||||.|||...|.|..||.:||.|.||
Yeast   225 SIDSDLNSLLMLLTASSLLPKGLFLDKTIANARTELKWECDYNREARALQKFEALLKDDPAFEVP 289

Human   311 AVVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLY 375
            .|..|..|..::.|....|..:.:....||:.:|.|...::.|||.|:..|::||||||||||||
Yeast   290 HVFPEYTTDNIITMTRMEGTEIMKLPKASQETKNFISENIMRLCLEEIATFKYMQTDPNWANFLY 354

Human   376 DASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVE 440
            :..:.::.||||||||.|..:|...|.:::..|...||....:.|..|.:|||.|:::..||||:
Yeast   355 NGRTKKIELLDFGASRPFAEDFILKYRKLLTYATLRDRKGAYEMSVQLGYLTGLESQSMKDAHVD 419

Human   441 AVMILGEPFA--TQGPYDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGAFLACAHLR 503
            :|:.|||||.  ....:||.....:.||:..|.::|..||||||||||:||||.:|.||.||.:.
Yeast   420 SVLTLGEPFRGDVDKSFDFKDQTVSDRIRGNIGLMLNERLCPPPEETYSLHRKFSGIFLLCARMG 484

Human   504 AHIACRDLFQDTY 516
            |.:.|..||::.:
Yeast   485 ASVHCAKLFKEIF 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8B	NP_079152.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..86		7/30 (23%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	155..158		1/2 (50%)
		ABC1_ADCK3	175..424	CDD:270872	107/248 (43%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	216..219		2/2 (100%)
COQ8	NP_011396.1	ABC1_ADCK3	153..403	CDD:270872	107/249 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I417
Isobase	1	0.950	-	0	Normalized mean entropy	S962
OMA	1	1.010	-	-		QHG53666
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm52934
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810