DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8B and Coq8b

DIOPT Version :9

Sequence 1:	NP_079152.3	Gene:	COQ8B / 79934	HGNCID:	19041	Length:	544	Species:	Homo sapiens
Sequence 2:	NP_598531.2	Gene:	Coq8b / 76889	MGIID:	1924139	Length:	533	Species:	Mus musculus

Alignment Length:	525	Identity:	459/525 - (87%)
Similarity:	482/525 - (91%)	Gaps:	1/525 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MWLKVGGLLRGTGGQLGQTVGWPC-GALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRARE 64
            |||::|.:||.|.|.||:.|..|| |||||.||.||||....||..:||.|||||.|:|||||||
Mouse     1 MWLELGAMLRRTCGPLGRAVRLPCGGALGPRPHWWGPCRSCLAQSVHQDQPGRGLSEDDIRRARE 65

Human    65 ARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSEGGSGLD 129
            ||.||.|||||||||||||||||||||||:|||||||||||.|||:.|||:|||.||.||.|||.
Mouse    66 ARLRKAPRPQLSDRSRERKVPASRISRLASFGGLAVGLGLGALAEVTKKSLPGGSLQHEGVSGLG 130

Human   130 SSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMPRWQMLRV 194
            ||||||||||||||||||||||||||:|||||||||||||||||.|||||||||||||||||:||
Mouse   131 SSPFLSEANAERIVQTLCTVRGAALKIGQMLSIQDNSFISPQLQRIFERVRQSADFMPRWQMMRV 195

Human   195 LEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLK 259
            ||||||:|||.|||||||||||||||||||||||:|||||||||||||:||||||||:||||:||
Mouse   196 LEEELGKDWQDKVASLEEVPFAAASIGQVHQGLLKDGTEVAVKIQYPGVAQSIQSDVENLLALLK 260

Human   260 MSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGM 324
            ||..||.|||||||||.|||||||||||.|||||||.||:|||:||||||||||:||||||||||
Mouse   261 MSVGLPEGLFAEQSLQTLQQELAWECDYCREAACAQTFRKLLADDPFFRVPAVVQELCTTRVLGM 325

Human   325 ELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGA 389
            |||||:|||||||||||:|||||||||.|||||||||||||||||||||||||||||||||||||
Mouse   326 ELAGGIPLDQCQGLSQDIRNQICFQLLRLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGA 390

Human   390 SREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMILGEPFATQGP 454
            ||.||||||||||||||||||||||.|||||:|||||||||||||||||||||||||||||..||
Mouse   391 SRAFGTEFTDHYIEVVKAAADGDRDRVLQKSQDLKFLTGFETKAFSDAHVEAVMILGEPFAASGP 455

Human   455 YDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGAFLACAHLRAHIACRDLFQDTYHRY 519
            ||||:||||||||.||||||||||.|||||||||||||||||||||.|.||||||||||||||||
Mouse   456 YDFGAGETARRIQGLIPVLLRHRLRPPPEETYALHRKLAGAFLACARLHAHIACRDLFQDTYHRY 520

Human   520 WASRQ 524
            |||||
Mouse   521 WASRQ 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8B	NP_079152.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..86		33/40 (83%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	155..158		1/2 (50%)
		ABC1_ADCK3	175..424	CDD:270872	226/248 (91%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	216..219		2/2 (100%)
Coq8b	NP_598531.2	KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	156..159		1/2 (50%)
		ABC1_ADCK3	176..425	CDD:270872	226/248 (91%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	217..220		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I10968
eggNOG	1	0.900	-	-		E1_COG0661
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86731
Inparanoid	1	1.050	923	1.000	Inparanoid score	I6558
Isobase	1	0.950	-	0	Normalized mean entropy	S962
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D118642at7742
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		oto114998
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.320