DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8B and Coq8

DIOPT Version :9

Sequence 1:	NP_079152.3	Gene:	COQ8B / 79934	HGNCID:	19041	Length:	544	Species:	Homo sapiens
Sequence 2:	NP_572836.1	Gene:	Coq8 / 32239	FlyBaseID:	FBgn0052649	Length:	661	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	236/457 - (51%)
Similarity:	315/457 - (68%)	Gaps:	12/457 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    64 EARPRKTPR------PQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQS 122
            :|:|:|...      |:||..:::||||:|||.|:|:||||..|||||.|.|:.|.::      .
  Fly   203 DAQPKKKSDQPAIEVPELSKVAKQRKVPSSRIGRMASFGGLFAGLGLGTLNELTKGAL------G 261

Human   123 EGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMP 187
            .|||.......||.|||||||.|||.|||||||:||:|||||:|.:||||...||||||:||:||
  Fly   262 LGGSTSMREALLSPANAERIVDTLCKVRGAALKIGQILSIQDSSVVSPQLAKAFERVRQAADYMP 326

Human   188 RWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQ 252
            .||:.||:..:||.||:.::.|.|:.|||||||||||:..|.||.:||:||||||:||||:||:.
  Fly   327 DWQVERVMNTQLGADWRQRLKSFEDKPFAAASIGQVHRATLSDGMDVAIKIQYPGVAQSIESDID 391

Human   253 NLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELC 317
            ||:.:||:....|.|.|.:..::..::||.||.||.|||...:.||:::|..|.:.||.||::|.
  Fly   392 NLVGMLKVWDVFPQGFFIDNVVRVAKRELQWEVDYDREAEYTEKFREMIAPYPEYYVPRVVRDLT 456

Human   318 TTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQV 382
            |:.||..||..|||||:|..||.:.|..|...:|.||||||||...|||||||:||||||.|.::
  Fly   457 TSSVLTTELVPGVPLDKCFDLSYEHRRHIAASVLKLCLRELFEIECMQTDPNWSNFLYDAPSRRL 521

Human   383 TLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMILGE 447
            .|:|||::|.:..||..:|..|:.:||:.:|..||:.||::.||||:|||....|||:|||||||
  Fly   522 MLIDFGSTRFYRHEFIRNYRRVIMSAAENNRQGVLEMSREMGFLTGYETKQMEQAHVDAVMILGE 586

Human   448 PFATQGPYDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGAFLACAHLRAHIACRDLF 512
            .|...|.:|||...|..|:..|:|.::.|||||||||.|::||||:|.||.||.|...:.|...:
  Fly   587 IFRYDGDFDFGRQNTTERLAALVPTMVAHRLCPPPEEIYSIHRKLSGIFLLCARLNVRMNCVPFY 651

Human   513 QD 514
            :|
  Fly   652 KD 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8B	NP_079152.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..86		9/27 (33%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	155..158		1/2 (50%)
		ABC1_ADCK3	175..424	CDD:270872	127/248 (51%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	216..219		2/2 (100%)
Coq8	NP_572836.1	AarF	262..641	CDD:223733	206/378 (54%)
Coq8	NP_572836.1	ABC1_ADCK3	313..563	CDD:270872	127/249 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2677
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86731
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1533
Isobase	1	0.950	-	0	Normalized mean entropy	S962
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D128317at33208
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm40296
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820