DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8B and Coq8b

DIOPT Version :9

Sequence 1:	NP_079152.3	Gene:	COQ8B / 79934	HGNCID:	19041	Length:	544	Species:	Homo sapiens
Sequence 2:	NP_001012065.1	Gene:	Coq8b / 308453	RGDID:	1311356	Length:	528	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	446/525 - (84%)
Similarity:	477/525 - (90%)	Gaps:	6/525 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MWLKVGGLLRGTGGQLGQTVGWPC-GALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRARE 64
            |||::|.:||.|.|.||:.|..|| |||...||.||||....||:.:||.|||||.|::||||||
  Rat     1 MWLELGAMLRTTCGPLGRAVRLPCAGALRLRPHWWGPCRDCLAQRVHQDQPGRGLTEDEIRRARE 65

Human    65 ARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSEGGSGLD 129
            ||.||.|||||||||||||||||||||||:|||||||||||.|||:.|||:|||.||.||
  Rat    66 ARLRKAPRPQLSDRSRERKVPASRISRLASFGGLAVGLGLGALAEVTKKSLPGGSLQHEG----- 125

Human   130 SSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMPRWQMLRV 194
            |||||:||||||||||||||||||||:||||||||||.||||||.:||||||||||||||||::|
  Rat   126 SSPFLTEANAERIVQTLCTVRGAALKIGQMLSIQDNSLISPQLQRVFERVRQSADFMPRWQMMKV 190

Human   195 LEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLK 259
            ||||||:|||.|||||||||||||||||||||:|:|||||||||||||:|:|||||||||||:||
  Rat   191 LEEELGKDWQDKVASLEEVPFAAASIGQVHQGVLKDGTEVAVKIQYPGVAESIQSDVQNLLALLK 255

Human   260 MSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGM 324
            ||..||.|||||||||.|||||||||||||||||||.|::|||:||||||||||:||||||||||
  Rat   256 MSVGLPEGLFAEQSLQTLQQELAWECDYRREAACAQTFKKLLADDPFFRVPAVVEELCTTRVLGM 320

Human   325 ELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGA 389
            |||||:|||||||||||:|||||||||.||||||||||||||||||||||||||||:||||||||
  Rat   321 ELAGGIPLDQCQGLSQDIRNQICFQLLRLCLRELFEFRFMQTDPNWANFLYDASSHKVTLLDFGA 385

Human   390 SREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMILGEPFATQGP 454
            ||.||||||||||||||||||||||.|||||:|||||||||||||||||||||||||||||..|.
  Rat   386 SRAFGTEFTDHYIEVVKAAADGDRDRVLQKSQDLKFLTGFETKAFSDAHVEAVMILGEPFAASGS 450

Human   455 YDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGAFLACAHLRAHIACRDLFQDTYHRY 519
            ||||:||||||||.||||||||||.|||||||||||||||||||||.|.||||||||||||||||
  Rat   451 YDFGAGETARRIQGLIPVLLRHRLRPPPEETYALHRKLAGAFLACARLHAHIACRDLFQDTYHRY 515

Human   520 WASRQ 524
            |||||
  Rat   516 WASRQ 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8B	NP_079152.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..86		32/40 (80%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	155..158		1/2 (50%)
		ABC1_ADCK3	175..424	CDD:270872	222/248 (90%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	216..219		2/2 (100%)
Coq8b	NP_001012065.1	KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	151..154		1/2 (50%)
		ABC1_ADCK3	171..420	CDD:270872	222/248 (90%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	212..215		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	405	1.000	Domainoid score	I10578
eggNOG	1	0.900	-	-		E1_COG0661
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86731
Inparanoid	1	1.050	892	1.000	Inparanoid score	I6492
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D118642at7742
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		oto131454
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	15.380