DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8B and abc1

DIOPT Version :9

Sequence 1:	NP_079152.3	Gene:	COQ8B / 79934	HGNCID:	19041	Length:	544	Species:	Homo sapiens
Sequence 2:	NP_596237.1	Gene:	abc1 / 2540411	PomBaseID:	SPBC2D10.18	Length:	610	Species:	Schizosaccharomyces pombe

Alignment Length:	440	Identity:	199/440 - (45%)
Similarity:	267/440 - (60%)	Gaps:	12/440 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    83 KVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSEGGSGLDSSPFLSEANAERIVQTLC 147
            |||:|:.|||.::||||..|.:|.:.|..|:..        |.|..|.:..|:|.|.|.:|..|.
pombe   178 KVPSSQWSRLWHYGGLATSLSVGAIGEKMKRMW--------GISKDDGALLLNERNVEILVNKLT 234

Human   148 TVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEE 212
            .:||||||:|||||.||:..|.|::..|.||||..|..||..|:.:|:.:.||::|....:..:.
pombe   235 QMRGAALKMGQMLSFQDSKLIDPRVSQILERVRDGAHSMPEKQLEQVMVKNLGKNWMTHYSEFDR 299

Human   213 VPFAAASIGQVHQG-LLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQA 276
            .|.|||||||||:. |..:..||.||:||||:..||.||:.||..:||.|..||.|||.|.||.|
pombe   300 KPMAAASIGQVHRARLASNHMEVVVKVQYPGVMSSIDSDLNNLAYLLKASRILPKGLFLENSLAA 364

Human   277 LQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQD 341
            .::||.|||||.||||.|:.|..||.||..|:||.|.:|.....|:.:|...|:.|.: |..||.
pombe   365 ARKELKWECDYEREAAFAERFGSLLKNDSDFKVPMVFREASGPSVITLEYLHGIALGK-QKYSQA 428

Human   342 LRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVK 406
            .||.|.:.|...||||:.|:.||||||||:||||:..:.::.|||||||.|:..:|...|..::.
pombe   429 TRNHIGYLLTKQCLREISEYHFMQTDPNWSNFLYNGKTKKIELLDFGASIEYDEKFIKKYCRLLL 493

Human   407 AAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMILGEPFATQGP--YDFGSGETARRIQDL 469
            |||..:|:...:.|.:|.:|...|:....|||:.::..|.||||...|  ||||......|::..
pombe   494 AAAHRNREKCKKLSVELGYLNNHESAQMIDAHINSIFTLAEPFAFDAPDVYDFGDQTITARVKQQ 558

Human   470 IPVLLRHRLCPPPEETYALHRKLAGAFLACAHLRAHIACRDLFQDTYHRY 519
            |||:|..||.|||||||:|||:|:|.||.||.|.|.:.|::||......|
pombe   559 IPVMLDLRLQPPPEETYSLHRRLSGHFLLCAKLGAKVRCKELFSGMLKHY 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8B	NP_079152.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..86		2/2 (100%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	155..158		1/2 (50%)
		ABC1_ADCK3	175..424	CDD:270872	115/249 (46%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	216..219		2/2 (100%)
abc1	NP_596237.1	AarF	170..610	CDD:223733	199/440 (45%)
abc1	NP_596237.1	ABC1_ADCK3	261..511	CDD:270872	115/250 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	193	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I490
OMA	1	1.010	-	-		QHG53666
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm53613
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.950