DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8B and coq-8

DIOPT Version :9

Sequence 1:	NP_079152.3	Gene:	COQ8B / 79934	HGNCID:	19041	Length:	544	Species:	Homo sapiens
Sequence 2:	NP_498014.2	Gene:	coq-8 / 175647	WormBaseID:	WBGene00000767	Length:	755	Species:	Caenorhabditis elegans

Alignment Length:	484	Identity:	232/484 - (47%)
Similarity:	315/484 - (65%)	Gaps:	24/484 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    56 EEDIRRAREARPRKTPRPQLS---------------DRSRERKVPASRISRLANFGGLAVGLGLG 105
            |..|...::|:| |..||:|.               .||.|..|||:||.|||.||.||.||..|
Worm   264 ETAIFGTQKAKP-KVYRPELPKNFEVNLEMGNVHTLTRSNESSVPATRIGRLATFGQLAFGLLGG 327

Human   106 VLAEMAKKSMP-GGRLQSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFIS 169
            ..||:.:::.. |.|||.|   |:..:||||||||:|||.|||.|||||||:||||||||:|.:.
Worm   328 ATAEVTRRTFGIGKRLQEE---GIPKNPFLSEANADRIVATLCRVRGAALKLGQMLSIQDSSTVP 389

Human   170 PQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEV 234
            |.|..|||||||||||||..|:.|.:::..|.||:.|....::.|||.|||||||:.:|:||..|
Worm   390 PALLQIFERVRQSADFMPIKQVHRQMKDAFGDDWREKFEHFDDKPFACASIGQVHKAVLKDGRNV 454

Human   235 AVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQ 299
            |||:||||:|:.|.||:.||::||.:....|.|:|.:..:...::||..||||.|||...:.||:
Worm   455 AVKVQYPGVAEGIDSDIDNLVSVLSVGGIFPKGMFLDAFVGVARRELKQECDYEREARAMKKFRE 519

Human   300 LLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFM 364
            |:|:.....||.|:.||.::|||..||..|.|:|.|....|.:|:.|..:.:.|||:|:|.:|||
Worm   520 LIADWQDVYVPEVIDELSSSRVLTTELVYGKPVDACVEEPQVVRDYIAGKFIELCLKEIFLWRFM 584

Human   365 QTDPNWANFLY----DASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKF 425
            ||||||:||..    .....::.||||||||.:|.:|.|.|:.::|:|.|||:..:::.||::.|
Worm   585 QTDPNWSNFFLGKHPKTGEPRLVLLDFGASRAYGKKFVDIYMNIIKSAYDGDKKKIIEYSREIGF 649

Human   426 LTGFETKAFSDAHVEAVMILGEPFATQGPYDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHR 490
            |||:||....|||||:|||:||..|:..||:|.:.:...|||.||||:|.|||..||||.|:|||
Worm   650 LTGYETSVMEDAHVESVMIMGETLASNHPYNFANQDVTMRIQKLIPVMLEHRLTSPPEEIYSLHR 714

Human   491 KLAGAFLACAHLRAHIACRDLFQDTYHRY 519
            ||:|.:|..|.|:|.::|..||.:.:..|
Worm   715 KLSGCYLLAAKLKATVSCGGLFHEIHENY 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8B	NP_079152.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..86		12/44 (27%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	155..158		1/2 (50%)
		ABC1_ADCK3	175..424	CDD:270872	116/252 (46%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	216..219		1/2 (50%)
coq-8	NP_498014.2	AarF	298..>707	CDD:223733	206/411 (50%)
coq-8	NP_498014.2	ABC1_ADCK3	394..648	CDD:270872	116/253 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I1726
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	464	1.000	Inparanoid score	I936
Isobase	1	0.950	-	0	Normalized mean entropy	S962
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D128317at33208
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm16208
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.810