DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8B and coq8b

DIOPT Version :9

Sequence 1:	NP_079152.3	Gene:	COQ8B / 79934	HGNCID:	19041	Length:	544	Species:	Homo sapiens
Sequence 2:	XP_002938863.1	Gene:	coq8b / 100489004	XenbaseID:	XB-GENE-956767	Length:	621	Species:	Xenopus tropicalis

Alignment Length:	483	Identity:	317/483 - (65%)
Similarity:	379/483 - (78%)	Gaps:	7/483 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    52 RGLGEEDIRRAREARPRK-------TPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAE 109
            |||..::::||||::.:|       :.|.:||||:||||||||||||||||||||||||:|.|.|
Frog   133 RGLTADELKRARESKLQKGTEEQGRSKRQKLSDRARERKVPASRISRLANFGGLAVGLGIGALTE 197

Human   110 MAKKSMPGGRLQSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQH 174
            :.|:|:.....|....|.|:|:..|:||||||||.|||.|||||||:|||||:|||:|||||||.
Frog   198 VVKQSLNREERQDSNHSILESNTLLNEANAERIVDTLCKVRGAALKIGQMLSLQDNNFISPQLQK 262

Human   175 IFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQ 239
            |||||||||||||.|||.:|||:|||.||:.|:...||.|||||||||||...|.||.|||:|||
Frog   263 IFERVRQSADFMPSWQMTKVLEDELGHDWREKLEYFEERPFAAASIGQVHLARLLDGREVAMKIQ 327

Human   240 YPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLAND 304
            |||||:||.|||:|||::||||.|:|||||.|.|:|.||:||.|||||.|||..|:.||.||:.|
Frog   328 YPGIAESINSDVENLLSILKMSVAIPAGLFPENSVQVLQKELTWECDYTREAKSAKRFRHLLSKD 392

Human   305 PFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPN 369
            |||.||.|:.||.|.|||.|||..|||||||..:.|:.||||.:.:|.|||:|:|||.|||||||
Frog   393 PFFSVPQVIDELTTERVLTMELVSGVPLDQCVEMDQETRNQISYNILRLCLQEVFEFHFMQTDPN 457

Human   370 WANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAF 434
            |:||.||..|::|.|||||||||||.:|||.||||:||||||||..|||||:|||||||||||.|
Frog   458 WSNFFYDTESNKVMLLDFGASREFGEKFTDDYIEVIKAAADGDRAKVLQKSQDLKFLTGFETKVF 522

Human   435 SDAHVEAVMILGEPFATQGPYDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGAFLAC 499
            .:||::|||||||.|.:..|::||:..|.|||.|||||:|:.||.|||||||:||||:||:||.|
Frog   523 EEAHIDAVMILGEAFVSDVPFNFGTQNTTRRIHDLIPVMLKDRLTPPPEETYSLHRKMAGSFLIC 587

Human   500 AHLRAHIACRDLFQDTYHRYWASRQPDA 527
            |.|:|.|.|::|||..|..||..|...|
Frog   588 AKLQAVIPCKELFQRFYCEYWERRSNGA 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8B	NP_079152.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..86		18/40 (45%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	155..158		1/2 (50%)
		ABC1_ADCK3	175..424	CDD:270872	172/248 (69%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	216..219		2/2 (100%)
coq8b	XP_002938863.1	ABC1_ADCK3	262..512	CDD:270872	172/249 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86731
Inparanoid	1	1.050	614	1.000	Inparanoid score	I6276
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D118642at7742
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980