Protein Alignment DOK3 and Dok

DIOPT Version :10

• Sequence 1: NP_079148.3
• Gene: DOK3 / 79930
• HGNCID: 24583
• Length: 440
• Species: Homo sapiens
• Sequence 2: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 113/522 - (21%)
• Similarity: 178/522 - (34%)
• Gaps: 164/522 - (31%)

Human     4 LETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGE 68
            |..|.:.|....: :...|.|.|  :.||:.....|:||||..|.::       ||:.
  Fly    12 LNVPTQTGFSLNR-ISKKKACSR--YCLLFKASRHGIARLEMCESKE-------DRNP------- 59

Human    69 RRVIRLADCVSVLPADGESCP--------RDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFPG 125
             ::..|.:||.:..   |..|        |.....|.|::|       :..:.|:..:..:||..
  Fly    60 -KIFTLENCVKITQ---EPPPERLIHIVKRQATLTLSTSSE-------EELKDWITALQTVAFCD 113

Human   126 TGEASSGSTDAQSPKRGLVPMEE-NSIYSSWQEVGEFPVVVQRTEAATRCQLKGPA-LLVLGPDA 188
            |           ||..|:..:|| |.:|.|..: |.|.:.:..:||:.||.::... :|.:.|..
  Fly   114 T-----------SPSGGIGAIEEDNDLYCSSFD-GLFIITLIPSEASIRCCIEPKTYMLQMTPTE 166

Human   189 IQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLF-------------------- 233
            :||:.......:..|||.|:||:|...|.|:|||||:|.:|||:|
  Fly   167 LQLKSEDLGATIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSAKMKS 231

Human   234 --------AFST-PCAPDLCRAVAGAIARQRERLP------------ELTRPQPCPLPRA--TSL 275
                    :.|| .|..:...|.||.....|..||            |:...|.|...|.  :|.
  Fly   232 MKKLISGDSLSTLECGENQFSAAAGMEPGSRSPLPPSPSSNPHGGEFEINSTQSCISLRGFISSN 296

Human   276 PSLD----------------------TPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPN 318
            .||:                      |.|....:|......:|...|:....|:..|
  Fly   297 DSLNNFSAGGGGASGATATGGGVLGSTGGITLSVPANSNSNSSSSKHIPNKPPRKSP-------- 353

Human   319 DLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEGPGSRSPTTSPIY---HNGQ 380
            ......|.::.|           ||.:.:...|            .|.:.|...|.:.   ..|:
  Fly   354 TTHCDKYRNIVK-----------YEPVAITTIS------------SPSANSDVNSSVILKPLEGE 395

Human   381 DLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKA-KLVTLLSRERRKG--------PAP 436
            .:|.|..|.|...:      |.|.....:..|.|:..::. :.:|...|.|..|        |..
  Fly   396 SISLPETAADLPPD------LPLRNESASKAPPPERDYECIENITEAWRTRGVGDVRHSERMPIL 454

Human   437 CD 438
            ||
  Fly   455 CD 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DOK3	NP_079148.3	PH_DOK1,2,3	9..123	CDD:270195	24/121 (20%)
		PTB_DOK1_DOK2_DOK3	157..255	CDD:269914	35/127 (28%)
Dok	NP_572391.1	PH	6..107	CDD:459697	26/122 (21%)
		IRS	138..233	CDD:460473	28/94 (30%)