DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B4 and CG33298

DIOPT Version :9

Sequence 1:	XP_011520348.1	Gene:	ATP8B4 / 79895	HGNCID:	13536	Length:	1257	Species:	Homo sapiens
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1363	Identity:	409/1363 - (30%)
Similarity:	640/1363 - (46%)	Gaps:	313/1363 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    64 QYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQLIPEISSLTWFTTIVPLVLVITMT 128
            |:..|:|.|:||.:|:|:|.||.|||.||||.||:.:::|..:||||:......::|::.|:.:|
  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313

Human   129 AVKDATDDYFRHKSDNQVNNRQSEVL--INSKLQNEKWMNVKVGDIIKLENNQFVAADLLLLSSS 191
            ||||..:|..|..||.::||....|.  ...:.:..||..::||||:.|.||:.|.||:|||.:|
  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTS 378

Human   192 EPHGLCYVETAELDGSLCCYKDVPWVECQLFGAQEALPTFLKQETNLKVRHALSVTSELGADISR 256
            :|.|:||::|.:|||                            |||||.|..:....|: ..|..
  Fly   379 DPQGVCYIDTCDLDG----------------------------ETNLKRREVVRGFEEM-QSIFV 414

Human   257 LAGFDGIVVCEVPNNKLDKFMGILSWKDSKH-SLNNEKIILRGCILRNTSWCFGMVIFAGPDTKL 320
            .:.|...|..:.|..||.:|.|.|.....:. .::.|.::||...|:||.:..|:|::||.:||.
  Fly   415 PSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKS 479

Human   321 MQNSGKTKFKRTSIDRLMNTLVLWIFGFLICLGIILAIGNSIWESQTGDQFRTF--LFWNEGEKS 383
            |.|:...::||:.:::.||..|:|....|:.|.::.|||..:|.|    .|..|  .:....:.:
  Fly   480 MLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLS----SFTHFPVPYLPPNKLT 540

Human   384 SVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVARTTTLNEEL 448
            :.......||:||:||..::|:||||::|:.::...:.|:.:..::.:........|...:.|||
  Fly   541 ANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEEL 605

Human   449 GQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDDLDQ---------KTEITQEKEPVDFSVK 504
            |||::||:|||||||:|.|.|:||.:||..|.....:|::         ...|..:....|.:..
  Fly   606 GQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQL 670

Human   505 SQADREFQFFDHHLMESIKMGDPKVHEFLRLLALCHTVM-------------------------- 543
            :|.    .:...|..        ::.|||.:||:|:||:
  Fly   671 TQG----TYLTPHAQ--------RIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPA 723

Human   544 ----------------------------------------------------------------- 543

  Fly   724 NLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPA 788

Human   544 -------------------SEENSA---------------------------------------- 549
                               ||..|.
  Fly   789 QSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQG 853

Human   550 ------------------GELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIE--ELGTLVTY 594
                              |..:|:.:||||.|||.||.::.....:|:|..|.:.  ..|....|
  Fly   854 KRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREY 918

Human   595 QLLAFLDFNNTRKRMSVIVRNPEGQ-IKLYSKGADTILFEKLHPSNE-----VLLSLTSDHLSEF 653
            ::|..|.|:::||.||::||....| |.||:||||:.:...|.|.:.     :|...|...|..:
  Fly   919 EILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRY 983

Human   654 AGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGATAVEDKLQ 718
            |.||||.|.:|.|.|:...:.:|....::...:.|.|:.|:...:.::|.:|.|||||.:||:||
  Fly   984 AREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQ 1048

Human   719 EGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIA-GNNAVEVR------- 775
            :||.||:.||..|.|.:|||||||.||||||.|:..:.|..|..:.:.| ..:|.|..
  Fly  1049 DGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTD 1113

Human   776 EELRKAKQNL-FGQNRNFSNGHVVCEKKQQLELDSIVEETITGDYALIINGHSLAHALESDVKND 839
            .|..|....| :||:         ..|||:               ||:::|.:|...|  |.|:.
  Fly  1114 MENDKTTSTLGYGQS---------LRKKQR---------------ALVVDGKTLTFIL--DPKSK 1152

Human   840 L----LELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQ 900
            |    |.|:..|.:|:|||.||||||.:|::||:..|..||||||||||||||:.|.:|||||||
  Fly  1153 LILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQ 1217

Human   901 EGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQT 965
            ||:|||:|:|::..:||||:||||.||.|.|.|:.:.:.||||||.||..:.||:..:||||.|.
  Fly  1218 EGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQV 1282

Human   966 VYDQWFITLFNIVYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYT 1030
            :.||.::.|:|:::||||.||:|::|:.|::...:..|.|||.|:|.:.:....|::.:|..:|.
  Fly  1283 MMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQ 1347

Human  1031 SLVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIA 1095
            |||:||:...|:   |..|    .....|..|:..|.:....|..|::...||.::.:.|..|:.
  Fly  1348 SLVIFFVALCAY---AESD----VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLG 1405

Human  1096 IY--FSILFTMHSNGIFGIFPNQ---FPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKV 1155
            .:  |:|::.......||:..:.   |....:|.|       ||||:|:||.:|:|.:....:::
  Fly  1406 SFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH-------WLVIMLSTVVAVLPRLLLTTVRI 1463

Human  1156 DLYPTLSDQIRRWQKAQKKARPPSSRRPRTR---------RSSSRRSGYAFAHQEGYGELITS 1209
            .|.|..|.::..           .|:|.|:|         ||:|..|.|.........::||:
  Fly  1464 SLCPDDSTKVIL-----------QSKRERSRGEALLVTWSRSTSASSIYRITDYGSKNQIITT 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B4	XP_011520348.1	PhoLip_ATPase_N	51..116	CDD:292826	25/51 (49%)
		ATPase-Plipid	65..1167	CDD:273734	397/1309 (30%)
		Cation_ATPase	538..634	CDD:289987	39/266 (15%)
		HAD_like	<875..906	CDD:304363	25/30 (83%)
		PhoLip_ATPase_C	906..1160	CDD:292829	87/258 (34%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	25/49 (51%)
		ATPase-Plipid	250..1473	CDD:273734	397/1307 (30%)
		E1-E2_ATPase	302..>394	CDD:278548	38/119 (32%)
		Cation_ATPase	<880..965	CDD:289987	33/84 (39%)
		HAD_like	<1177..1240	CDD:304363	40/62 (65%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	87/258 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830