DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment itk and Src42A

DIOPT Version :9

Sequence 1:	NP_571179.1	Gene:	itk / 798906	ZFINID:	ZDB-GENE-990415-261	Length:	616	Species:	Danio rerio
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	398	Identity:	157/398 - (39%)
Similarity:	243/398 - (61%)	Gaps:	29/398 - (7%)

- Green bases have known domain annotations that are detailed below.

Zfish   220 YVTEKLSNNIEKFEWYNKDINRTEAE-DLLMQENKDGGFMVRN--SKHAGVYTVSIFTRVSGSNG 281
            ::.||        .||.:.|.|.||| .||:.||:.|.|::|:  |:| ..|::|:      .:|
  Fly  1204 FLNEK--------SWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRH-NDYSLSV------RDG 1253

Zfish   282 EKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELIRYHQHNPAGLITRL-RHCVSRNVPNSAR 345
            :   .||||:|:...||.   :::|.:..|.|:.||:.::..:..||...| :.||....|.:..
  Fly  1254 D---TVKHYRIRQLDEGG---FFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEG 1312

Zfish   346 IKELSSDKWEIHPDEVKLSVELGSGQFGLVWKGSWQD-REVAVKTVREGFMSEEEFKEEAQVMMK 409
            :...:.|:|||....:|...:|||||||.||:|.|.: ..||:||::.|.|..::|..|||:|.|
  Fly  1313 LSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKK 1377

Zfish   410 LSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLRAKKGK---LSQKALLEMCLDVSEGMAYLE 471
            |.|.:|:|||.|.|...|||::.|.|::|.|.|:|:|..||   |..:.|::|...::.||||||
  Fly  1378 LRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLE 1442

Zfish   472 SSNFIHRDLAARNCLVSENSVVKIADFGMTRFVLDDQYTSSHGSKFPVRWSSPEVIKFGKYSSKS 536
            |.|:|||||||||.||.:.::|||||||:.|.:.:|:|.:..|::||::|::||...:.|:|.||
  Fly  1443 SQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKS 1507

Zfish   537 DVWSFGVFMWEVYSEGRTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSWKEKPEDRPS 601
            ||||||:.:.|:.:.||.||...:|:||:..:..|:|:.:|..|...:||:|...|.:.|..||:
  Fly  1508 DVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPT 1572

Zfish   602 FALLLHEL 609
            |..|..:|
  Fly  1573 FETLQWKL 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
itk	NP_571179.1	PH	5..110	CDD:278594
		PH_Btk	7..147	CDD:269944
		SH3_Tec_like	170..223	CDD:212702	0/2 (0%)
		SH2_Tec_family	227..338	CDD:198188	36/114 (32%)
		PKc_like	356..610	CDD:304357	115/258 (45%)
		Pkinase_Tyr	361..609	CDD:285015	113/251 (45%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	34/103 (33%)
		PTKc_Frk_like	1319..1587	CDD:270653	118/262 (45%)
		Pkinase_Tyr	1328..1580	CDD:285015	113/251 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910