Protein Alignment itk and Src42A

DIOPT Version :10

• Sequence 1: XP_073777810.1
• Gene: itk / 798906
• ZFINID: ZDB-GENE-990415-261
• Length: 630
• Species: Danio rerio
• Sequence 2: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 185/538 - (34%)
• Similarity: 282/538 - (52%)
• Gaps: 78/538 - (14%)

Zfish   131 LKYHPDFWGEGKWRCCQQTEKLATGCSEYYPNGAKPLPPTP--DPSRRSSEPEERIVVALRNFTP 193
            ||.|         ||.||.::..........|..:.:..|.  .|.||.|           |.||
  Fly  1085 LKQH---------RCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWS-----------NQTP 1129

Zfish   194 KEHT------DLPLQKDEE--YFIVDCSEPNWWT---VKDKDGNVGSVPCIYVT------EKLSN 241
            .:.|      :|||...|:  .....||.....|   :...|.:..:..|...|      :..|.
  Fly  1130 LKCTCHPATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSR 1194

Zfish   242 NIEKF---------EWYNKDINRTEAE-DLLMQENKDGGFMVRN--SKHAGVYTVSIFTRVSGSN 294
            .:.:|         .||.:.|.|.||| .||:.||:.|.|::|:  |:| ..|::|:      .:
  Fly  1195 RLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRH-NDYSLSV------RD 1252

Zfish   295 GEKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELIRYHQHNPAGLITRL-RHCVSRN----- 353
            |:   .||||:|:...||.   :::|.:..|.|:.||:.::..:..||...| :.||..|
  Fly  1253 GD---TVKHYRIRQLDEGG---FFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQTNSFSGV 1311

Zfish   354 ----VPNSARIKELSSDKWEIHPDEVKLSVELGSGQFGLVWKGSWQD-MEVAVKTVREGFMSEEE 413
                .|.:..:...:.|:|||....:|...:|||||||.||:|.|.: ..||:||::.|.|..::
  Fly  1312 FEIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKD 1376

Zfish   414 FKEEAQVMMKLSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLRAKKGK---LSQKALLEMCL 475
            |..|||:|.||.|.:|:|||.|.|...|||::.|.|::|.|.|:|:|..||   |..:.|::|..
  Fly  1377 FLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAA 1441

Zfish   476 DVSEGMAYLESSNFIHRDLAARNCLVSENSVVKIADFGMTRFVLDDQYTSSHGSKFPVRWSSPEV 540
            .::.|||||||.|:|||||||||.||.:.::|||||||:.|.:.:|:|.:..|::||::|::||.
  Fly  1442 QIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEA 1506

Zfish   541 IKFGKYSSKSDVWSFGVFMWEVYSEGRTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWS 605
            ..:.|:|.||||||||:.:.|:.:.||.||...:|:||:..:..|:|:.:|..|...:||:|...
  Fly  1507 ANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLEC 1571

Zfish   606 WKEKPEDRPSFALLLHEL 623
            |.:.|..||:|..|..:|
  Fly  1572 WHKDPMRRPTFETLQWKL 1589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
itk	XP_073777810.1	None
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	34/103 (33%)
		PTKc_Frk_like	1328..1596	CDD:270653	118/262 (45%)