Protein Alignment ZC3H14 and sut-2

DIOPT Version :10

• Sequence 1: NP_079100.2
• Gene: ZC3H14 / 79882
• HGNCID: 20509
• Length: 736
• Species: Homo sapiens
• Sequence 2: NP_001360618.1
• Gene: sut-2 / 178847
• WormBaseID: WBGene00022019
• Length: 742
• Species: Caenorhabditis elegans
• Alignment Length: 849
• Identity: 197/849 - (23%)
• Similarity: 324/849 - (38%)
• Gaps: 271/849 - (31%)

Human     5 TEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGV 69
            :|:|:|:::||:.||:|||.|||:|||||||||:||||.:.||.:||:||:|.:|.:|..||..:
 Worm    10 SEVSKKLKAAIRAKLEELGVYVDDELPDYIMVMIANKKEKVQMKDDLNLFIGKSTAKFVDWLFDL 74

Human    70 LDKLRSVTTEPSSLKSSDTNIFDSNVPSNKSNFSRGDERRH-EAAVPPLAIPSARPEKRDSRVST 133
            .|:|::     :|.|..:|        |.|..    |:|:. ||..........|.::::.....
 Worm    75 FDRLQN-----ASNKQGET--------SKKEE----DKRKELEATAAAKEHEEKRRKEKEEHEKE 122

Human   134 SSQESKTTNVRQTYDDGAATRLMSTVKPLREPAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKK 198
            ..:|.:....||...|             ||.         :.|.:...:|....:|.   |:::
 Worm   123 LQKEKEREKERQRERD-------------REK---------RAEEEKRREEKRKEIQR---SKRR 162

Human   199 PTVTLTYGSSRPSIEIYRPPASRNADSGVHLNRLQFQQQQNSIHAAKQLDMQSSWVYETGRLCEP 263
            .|               |..::..:|...|   ::.:.:::..|..|.        :..||..|
 Worm   163 RT---------------RSRSNTYSDEEEH---VRARGEKHDRHHHKD--------HRRGRSHE- 200

Human   264 EVLNSLEETYSPFFRNNSEKMSMEDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSI 328
                                          ||: :.|::|:....:.|.:              :
 Worm   201 ------------------------------RKI-ITSTIVRQASASPDKK--------------L 220

Human   329 SSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESV--------TKTTNYSTVPQKQTLPVAP 385
            .|:|:|  |...||:...:.:....:.|:|::||..|.        ::|.:...:...:.||..|
 Worm   221 HSTVTV--KRNIRPTGDQNIKGRGTMFLRAMNEASVSAGYGSSSKRSETHHEDDMSDVEALPSKP 283

Human   386 RTRTSQEELLAEVVQGQSRTPRISPPIKEE---------ETKG--DSVEKNQGTQQRQLLSRLQI 439
            .:..|.::.:.:.:...|:|.  .|||:|:         :|.|  ..:.|..|.::....:|:|.
 Worm   284 ASTKSPKKSIRDRMSRISKTS--EPPIEEDDAVVLEDFAQTGGGPQMILKLSGGREAIKKTRIQD 346

Human   440 DPVMAETLQMSQDYYDMESMVHADTRSFILKKPKLSEEVV---VAPNQESGMKTADS--LRVLSG 499
            ..|:.:.|:.......:|:...|...:...::||...:.:   :.|:::| ..|.||  ::..:|
 Worm   347 RIVVDDGLRRGLLKRKIETASGASAGAATSEEPKSKHDRIIFDITPSRDS-TPTDDSPTMQKWNG 410

Human   500 HLM---QTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMCFEGMKPVNQ-----------T 550
            .:.   .:.:....::.....|:....|:.....:..:::|      :.|.:|           |
 Worm   411 QIEIGDDSEESEDDEEAEIDAFVAEARGIARRESFRDEEDE------LPPTHQLSGGPYAYHHST 469

Human   551 AASNKGLRGLLHPQQLHLLSRQLEDPNGSFSNAEMSELSVAQKPEKLLERCKYWPACKNGDECAY 615
            ||..      ..|..|.:||.|.....|          ..|::...:.|||.:||.|..||.||:
 Worm   470 AAPT------YIPTPLSVLSEQQNQMGG----------GAAKEDHHVKERCIFWPKCTKGDTCAF 518

Human   616 HHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTH----------------------VS 658
            .||.:.||.||||.|..:|||:||.|::|..|||..|||||                      .|
 Worm   519 MHPTTNCKNFPNCTFGIRCLFIHPPCRFDRFCTKKHCPFTHHGTGGQQPGGAQLTSEFKNPLTSS 583

Human   659 RRIPVLSP----------------------------------KPA-------------------- 669
            |.:.|.||                                  |||
 Worm   584 RMLTVPSPFIAATAAAVEELPKPAARGALGSLAEKLAASIKKKPAPGAESEKKEEKSDENESKAE 648

Human   670 -----VAPP----------APPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTI 719
                 |||.          ||..|..||||..||:...|.|.|||.|||...|..|.|.|||...
 Worm   649 EPKAEVAPVQPKPLPDFSIAPLHSMVLCRYAGACRNPICHFKHPKECRFGANCRNPSCYFYHKPA 713

Human   720 NVPP 723
            ...|
 Worm   714 GAAP 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZC3H14	NP_079100.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..145		11/68 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..350		7/39 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..430		10/42 (24%)
		zf-CCCH_2	601..618	CDD:464217	8/16 (50%)
		zf-CCCH_2	621..639	CDD:464217	10/17 (59%)
		zf-CCCH_2	681..698	CDD:464217	8/16 (50%)
sut-2	NP_001360618.1	zf-CCCH_2	504..521	CDD:464217	8/16 (50%)
		zf-CCCH_2	525..542	CDD:464217	10/16 (63%)