DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF212 and CG6654

DIOPT Version :9

Sequence 1:	NP_036388.2	Gene:	ZNF212 / 7988	HGNCID:	13004	Length:	495	Species:	Homo sapiens
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	124/551 - (22%)
Similarity:	187/551 - (33%)	Gaps:	138/551 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    18 LTSSTLPSQATEKSSYFQTTEISLWTVVAAIQAVEKKMESQAARLQSLEGRTGTAEKKLADCEKM 82
            |..:.||.:...|.|    ....:.|...|:|....:.:...|.:|: :..|.|..::.....|.
  Fly    79 LLPNALPEEPDSKVS----ISCPVATTDQAVQTTSWEPDRCTASVQT-DAVTTTDAEQNTSLIKS 138

Human    83 AVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVSRSLENDG 147
            .:......||:..|.     :|.|....:|...:|       ||::....|.|..
  Fly   139 TISVDLDYEGEGEVF-----DYELPDEPVEKTTSL-------ILQVQGNLKDEKE---------- 181

Human   148 VCFTEQEWENL--EDWQKELYRNVMESNYETLVSLKVLGQTEGEAELGTEMLGDLEEEGPGGAHP 210
            |.||:   .|:  |....||.:.:.|.|      |.:....:.|||:.|.....:.      ...
  Fly   182 VVFTQ---TNVIYEGDDHELEQQIRECN------LAIFEGVDNEAEIITVTAPQVT------TRK 231

Human   211 AGGVMIKQELQYTQEGPADLPGEFSCIAEEQAFLSPEQTELWGGQGSSVLLETGPGDS------- 268
            :...::.|:.....:.|.....|...:.:||...|.::|....|.....:..|.|.|:
  Fly   232 SAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQH 296

Human   269 ------TLEEPVGSRVPSSSRTVGC---PKQKSHRQVQLDQECGQGLKLKKD----------TSR 314
                  .|..|....|...|.|.|.   |:.|.|     ...|..|..::|.          .:|
  Fly   297 RLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYH-----CDRCNAGFAVEKSLMIHRRQKGCINR 356

Human   315 PYECSECEITFRYKQQLATHLRSHSGWGSCTPE-----EPEE----------------------- 351
            .|:|:|||..|.....||.|..|| |..:| ||     :.:|
  Fly   357 NYKCNECEKVFVSPDHLAEHQASH-GAHNC-PECGIRCDSKEALSKHMVQGHKRNLRNQCNICQK 419

Human   352 ------SLRPRPRL-------------KPQTKKAKLHQ------------CDVCLRSFSCKVSLV 385
                  :||...|:             |..|:.|.|.|            |::|..||..|..|.
  Fly   420 VFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELT 484

Human   386 THQRCHLQEGPSAGQHVQERFSPNSLVALPGHIPWRKSRSSLICGYCGKSFSHPSDLVRHQRIHT 450
            :|.|.|..:.|...:....||:.:  .:|..|...........|..|...|:..:.|..|:|.||
  Fly   485 SHARTHTGDKPFECEVCLARFTTS--CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHT 547

Human   451 GERPYSCTECEKSFVQKQHLLQHQKIHQRER 481
            |||||.|..|.|:|.|:.....||:.||.||
  Fly   548 GERPYVCPFCSKTFTQRGDCQMHQRTHQGER 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF212	NP_036388.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		3/10 (30%)
		KRAB_A-box	142..180	CDD:143639	9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..290		9/41 (22%)
		C2H2 Zn finger	318..338	CDD:275370	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..361		10/70 (14%)
		COG5048	<367..479	CDD:227381	37/123 (30%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		zf-C2H2	429..449	CDD:306579	6/19 (32%)
		zf-H2C2_2	441..466	CDD:316026	14/24 (58%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..495		4/6 (67%)
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	124/551 (23%)
		C2H2 Zn finger	331..354	CDD:275368	3/22 (14%)
		COG5048	<357..570	CDD:227381	56/216 (26%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	4/21 (19%)
		C2H2 Zn finger	414..434	CDD:275368	3/19 (16%)
		zf-H2C2_2	427..451	CDD:290200	4/23 (17%)
		C2H2 Zn finger	442..490	CDD:275368	13/47 (28%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	7/24 (29%)
		C2H2 Zn finger	498..518	CDD:275368	4/21 (19%)
		zf-H2C2_2	510..534	CDD:290200	4/23 (17%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100