DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF212 and CG11695

DIOPT Version :9

Sequence 1:	NP_036388.2	Gene:	ZNF212 / 7988	HGNCID:	13004	Length:	495	Species:	Homo sapiens
Sequence 2:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	249	Identity:	56/249 - (22%)
Similarity:	86/249 - (34%)	Gaps:	73/249 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   274 VGSRVPSSSRTVGCPKQKSHRQVQLDQECGQGLKLKKDTSR-------PYECSECEITFRYKQQL 331
            :.|||....|...|.        ..|:.....:.|:....|       |:.|..|...|:.||.|
  Fly   314 IHSRVHQQERNEQCK--------HCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNL 370

Human   332 ATHLRSHSGWGSCTPE----------EPEESLRPRPRLKPQTKKAKLHQCDVCLRSFSCKVSLVT 386
            ..|.|:....||..||          ..|.|||         |...:|.....||.:.|
  Fly   371 LVHKRTVHREGSQLPEVQCQECQVWLSDENSLR---------KHMYMHLDAASLRQWKC------ 420

Human   387 HQRCHLQEGPSAGQHVQERFSPNSLVALPGHIPWRKSRSSLICGYCGKSFSHPSDLVRHQRIHTG 451
             ::|.|::|              |...|..||.:...:....|.:|.|.|.....|..|...|||
  Fly   421 -EQCGLEKG--------------SRAKLAAHIRYHHPKEYHKCTHCAKEFKSSRSLEEHTATHTG 470

Human   452 ERPYSCTECEKSFVQKQHLLQHQK-IH-----------------QRERGGLALE 487
            :..|.|..||::|....::.:|:: :|                 ::::|.|.|:
  Fly   471 QDLYECAFCERTFKNSGNMHKHRRQMHAAQVAALQQQKKVPPSKRKDKGDLLLD 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF212	NP_036388.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		KRAB_A-box	142..180	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..290		5/15 (33%)
		C2H2 Zn finger	318..338	CDD:275370	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..361		8/33 (24%)
		COG5048	<367..479	CDD:227381	27/129 (21%)
		C2H2 Zn finger	371..391	CDD:275368	3/19 (16%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		zf-C2H2	429..449	CDD:306579	6/19 (32%)
		zf-H2C2_2	441..466	CDD:316026	10/24 (42%)
		C2H2 Zn finger	457..477	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..495		4/29 (14%)
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071
		C2H2 Zn finger	268..289	CDD:275368
		C2H2 Zn finger	299..319	CDD:275368	2/4 (50%)
		C2H2 Zn finger	327..348	CDD:275368	4/28 (14%)
		C2H2 Zn finger	357..376	CDD:275368	7/18 (39%)
		C2H2 Zn finger	389..409	CDD:275368	5/28 (18%)
		C2H2 Zn finger	420..440	CDD:275368	8/40 (20%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..494	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100