Protein Alignment UBA5 and UBA3

DIOPT Version :10

• Sequence 1: NP_079094.1
• Gene: UBA5 / 79876
• HGNCID: 23230
• Length: 404
• Species: Homo sapiens
• Sequence 2: NP_015391.1
• Gene: UBA3 / 856179
• SGDID: S000006270
• Length: 299
• Species: Saccharomyces cerevisiae
• Alignment Length: 245
• Identity: 56/245 - (22%)
• Similarity: 89/245 - (36%)
• Gaps: 90/245 - (36%)

Human    76 VAIVGVGGVGSVTAEMLTRCGIGKLL-LFDYDKVELANMNRLF-FQPHQAGLSKVQAAEHTLRNI 138
            :.::|.||:|....:.||.....|.: :.|.|.:||.|:||.| |.....|..|.|.|...:...
Yeast     5 ILVLGAGGLGCEILKNLTMLSFVKQVHIVDIDTIELTNLNRQFLFCDKDIGKPKAQVAAQYVNTR 69

Human   139 NPDVLFEVHNYNITTV-----ENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNEL 198
            .|.:....|..::||:     ::||                  .::|.:|..|.|..||   ..|
Yeast    70 FPQLEVVAHVQDLTTLPPSFYKDFQ------------------FIISGLDAIEPRRFIN---ETL 113

Human   199 GQTWMES----------GVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAAS 253
            .:..:||          |.:| .:.||::.||||.:||:.|        :||            :
Yeast   114 VKLTLESNYEICIPFIDGGTE-GLKGHVKTIIPGITACWEC--------SID------------T 157

Human   254 LPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYNAMQDFFPTMSMKPNPQC 303
            ||                               :.||..|..::..||:|
Yeast   158 LP-------------------------------SQQDTVPMCTIANNPRC 176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBA5	NP_079094.1	ThiF_MoeB_HesA_family	52..297	CDD:238386	53/237 (22%)
		UFM1-interacting sequence (UIS). /evidence=ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27653677	334..346
		Linker. /evidence=ECO:0000269|PubMed:34588452	347..377
		UFC1-binding sequence (UFC). /evidence=ECO:0000269|PubMed:34588452	389..404
UBA3	NP_015391.1	Uba3_RUB	4..294	CDD:238765	56/245 (23%)