Protein Alignment RABEP2 and Rbpn-5

DIOPT Version :10

• Sequence 1: NP_079092.2
• Gene: RABEP2 / 79874
• HGNCID: 24817
• Length: 569
• Species: Homo sapiens
• Sequence 2: NP_611545.1
• Gene: Rbpn-5 / 37395
• FlyBaseID: FBgn0034585
• Length: 647
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 138/583 - (23%)
• Similarity: 246/583 - (42%)
• Gaps: 145/583 - (24%)

Human    34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSI---S 95
            |||..:..:.|.:|...|.|::|...||::....:.:   ....:.|||::|||.:::|:|   :
  Fly    58 EAEVSQSQQERRQLQAELDELKTHLMVADLKSQNELQ---LRDLKAQEEISSLQQLVQDTIEETA 119

Human    96 SYEAQITAL-----KQERQQQQQDCEEKERE---------LGRLKQLLS--RAYPLDSLEKQMEK 144
            .|:.::..|     |.::.|||...::.:.|         |.::|:.|.  |....|||....::
  Fly   120 HYKGEVERLRLELGKYQQIQQQTMAQQPQAESSGGIAPQVLNQVKKTLGSVRKLGTDSLNSSFQQ 184

Human   145 ---------------AHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGST 194
                           |.|::|.:..||..:::|::.||.||...:|.:|  .:......:||.||
  Fly   185 DEDTRASSKGNGKQYAPEEAEMMHSIVEQLQEEMKALKVKLREQDEQLQ--AKSASDESALHKST 247

Human   195 ELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPE 259
            .:                      ..||:...:| ..|...:..||..:...    |.:..|..:
  Fly   248 SM----------------------DVAESACESC-SLAEKKTEELGAHINKQ----QKQVDLLQK 285

Human   260 QEETASLV-STGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRS 323
            |     || |..|||.|.                        .|:||||...:|:.|..:
  Fly   286 Q-----LVESRETLVKEA------------------------ALRKDLEDQWQEKREAHK----- 316

Human   324 NEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLR 388
                 .::|.|..|.:.:||.|..:|....:.::.|..|:..:....:.::.:::.|..:|..|.
  Fly   317 -----SEVQSLRDQAKTNEQRLLDMQQKFLETKDEVIKQIQRVSDDRERVNKQLETLQADNDFLS 376

Human   389 AEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLC-------------------CTRQEAR---AR 431
            ...|.:     |::...:..:||::|.|||:|:.                   ||..|..   .|
  Fly   377 GRYLAT-----SEEIDNQYINLPNTVVELQELILRQQSELIQARVSSEYERQKCTSTEDEIQILR 436

Human   432 LQAQEHGAER------LRIEIVTLREALEEETVARASLE-GQLRVQREETEVLEASLCSLRTEME 489
            .|.:|...||      ::::|.:|::.:.|..|...:.| .:.:::|:|.| |...|...|.|:.
  Fly   437 AQLEESNNERRAYKRKMQLDIKSLQDRVTEHLVTVQAYETTKTQLERKEAE-LNKQLSECRVEII 500

Human   490 RVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVR 552
            .:|:...|....:  ::.:.|:..||.||.|.|.||:|||:|||.||:.||.:|.|:|  :||
  Fly   501 ELQEANEKYAKTN--ADYKTKIKTLQEELSTMETVQKDFVKLSQTLQMSLEELRHADT--EVR 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RABEP2	NP_079092.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		3/6 (50%)
		Rabaptin	21..>181	CDD:367545	44/180 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..265		13/84 (15%)
		Rab5-bind	291..546	CDD:462752	70/283 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..411		2/22 (9%)
Rbpn-5	NP_611545.1	Rabaptin	22..>374	CDD:367545	82/386 (21%)
		Rab5-bind	256..555	CDD:462752	84/350 (24%)
		FYVE_RABE_unchar	557..629	CDD:277278	2/3 (67%)