DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC11 and Patsas

DIOPT Version :9

Sequence 1:	XP_016865358.1	Gene:	ZDHHC11 / 79844	HGNCID:	19158	Length:	559	Species:	Homo sapiens
Sequence 2:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	254	Identity:	58/254 - (22%)
Similarity:	85/254 - (33%)	Gaps:	102/254 - (40%)

- Green bases have known domain annotations that are detailed below.

Human    26 PRISRVNGW----------SLPLHYFQVVTWAVFVGLSSATFGIFIPFLPHAW-----KYIAYVV 75
            |.:|...||          .|.|..|.|:.|...:.:..|        :|..|     .:..::.
  Fly   348 PSVSESWGWLFGGAGDSKGPLFLFLFSVLLWGYPMYMIRA--------IPITWNILRRSHYCFIY 404

Human    76 TGGIFSFHLVVHLIASCIDP------ADSNVRLMKNYSQPMPLFDRSKHAHVIQNQFCHLCKVTV 134
            ...:.   .:...||:..||      :|:..|.:|.    :|.||:.|..:|:..:.||.|:...
  Fly   405 WNAVM---WISWAIANRRDPGYIPLSSDAYYRAIKQ----IPYFDKLKKRNVMLTRLCHSCRCLR 462

Human   135 PQHPPPASHSLLDALSPGRTGLVPPRHLASSDGPLALPQPAHLGPDRRSPIHPSRNKKTKHCISC 199
            |                                                       .:.|||..|
  Fly   463 P-------------------------------------------------------LRAKHCRVC 472

Human   200 NKCVSGFDHHCKWINNCVGSRN-YWFFFSTVA-----SATAGMLCLIAI-----LLYVL 247
            |:|||.|||||.:|.||||.|| .|||...::     |.|....|...:     :||||
  Fly   473 NRCVSYFDHHCPFIYNCVGLRNRMWFFLFVLSVAVNCSFTIYFACYCVMIEGFTMLYVL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC11	XP_016865358.1	None
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738
		ANK repeat	148..181	CDD:293786
		ANK repeat	187..214	CDD:293786
		ANK repeat	216..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..314	CDD:293786
		Ank_4	283..336	CDD:316185
		DHHC	455..567	CDD:334580	34/132 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900