DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARHGEF5 and Exn

DIOPT Version :9

Sequence 1:NP_005426.2 Gene:ARHGEF5 / 7984 HGNCID:13209 Length:1597 Species:Homo sapiens
Sequence 2:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster


Alignment Length:1961 Identity:444/1961 - (22%)
Similarity:708/1961 - (36%) Gaps:505/1961 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    28 MRSSQVSALGLEAQEDEDPSYKWREEHRLSATQQSELRDVCDYAI----ETMPSFPKEGSADVEP 88
            ::.||.....|..::|....||..|:    |..|::||...|.||    ||.   .|...:...|
  Fly   179 LQDSQAKHKQLHREKDNFYKYKNAEQ----AKMQAKLRSSADEAILNASETR---AKRDDSGCLP 236

Human    89 NQESLVAEACDTPEHWEAVPQSLAGRQARTLAP---------PELWACPIQSEH-----LDMAPF 139
            ..:|..::|....:....|.:..|..|.|...|         .|..|   :.||     |.::..
  Fly   237 GVKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEVEVEFRA---KREHNRLEGLSLSAA 298

Human   140 SSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSS-DNSGQTRYYS---------PCEEHPAETN 194
            |:..|...|.::     |:.|..|........||| ..||..|.||         ....||:...
  Fly   299 SAQSGGSSESLQ-----TTTTSSSTPTTHSSVTSSTGRSGGRRKYSFKTHAGKSYHQHHHPSRRT 358

Human   195 QNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGFRGEGT----LREDVCADGL 255
            .|..|.:|.|....:|..:..:..|     ::.::||:..:....:...||    :.|...::|.
  Fly   359 SNMDSSNGGISMVAKLTHQFNEIIQ-----KDAKLLEQVKRNNGVWISRGTHVYKIVEKPTSEGK 418

Human   256 ---LGEEQMIEQV--NDEKGEQKQ------KQEQVQ----DVMLG---RQGERM--------GLT 294
               ..::..|..|  |.:|.|:.:      |.||:.    ::|.|   .:|.|:        |..
  Fly   419 GLPNADDNRISTVQRNIKKFERLEKPSVPLKSEQLMRKHLELMRGSSLSRGPRIKRNLKLPPGSV 483

Human   295 GEPEGLNDGE-------WEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKS 352
            |.||.....|       .||....:..|.:..|...||..:....|.:.......|:     |..
  Fly   484 GIPELAIVSEELKTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDELDLIMGEE-----GDE 543

Human   353 EEVTGKQEDH---GIKEK--GVPVSGQEAKEPESWDGGRLGAVGRARSREE-------------- 398
            ||:..||..|   .|.||  .....|:::..|         :..:|:.|||              
  Fly   544 EELRQKQRKHKYASIYEKLRFTFAKGRKSASP---------SPTKAQIREEVSIDEESIKDSTSE 599

Human   399 ----ENEHHGPSMPALIAP-----EDSPHCDL----FPGASYLMTQIPGTQTESRAEELSPAALS 450
                ..|.....:|..:.|     |||.|..|    |...:.::..:       .|.:|....|:
  Fly   600 DMVTRKEDFTLDLPKEVIPRAEDLEDSSHALLVSPCFEADAKILDAL-------EAVDLKLKVLN 657

Human   451 PSLEPIRCSHQPISLL-------------GSFLTEESPDKEIDQN-------------------- 482
            | |..:..:.....||             .|....::.:|:...|                    
  Fly   658 P-LNDVTTADGERELLLAANDDFEQRILPNSSFVYQAANKQYSNNQILLNQAVNVTLVNAIEGEQ 721

Human   483 ---SQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITP--------ASVSAR 536
               .|::..::|...::.:..:.....|..:|.:.....|.|..|  ||||        |..|:.
  Fly   722 MIMEQKQLMKVRDLELTERDIDQPLKRAEKSPEKDDTLEPESLYE--PITPVMDETKTEAQTSSL 784

Human   537 PPVAFPRRE--TSCAARAPETASAPLSMDD-----PSPCGTSEMCPAALYGFPSTG-----TSPP 589
            ..:...:.|  ........|.::..:..::     .|..|:.|.||....|:.|..     |:|.
  Fly   785 FKIYTKKSELVEDIYQTVEEASTVEVKPNNWLEGYESIAGSQEACPLTYDGYESFAPEEVVTTPT 849

Human   590 RPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQR--PPKPA---------IYSS 643
            .|.|  |||:         |.:..::.|:|.......:.|.:|.|  ||||.         ||.:
  Fly   850 TPSA--TGTL---------GRNTRDELPELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDT 903

Human   644 VTPRRDRRSGRDYSTVSASPTALST----LKQDSQESISNLERP-------------------SS 685
            :....:....:..|:.|:....|:|    |..:..||||::.|.                   ||
  Fly   904 IKGCYESMHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSS 968

Human   686 PPSIQPWVSPHNPAFATESP-------AYGS---------------------------------- 709
            ..|.....|.|......||.       .|||                                  
  Fly   969 SGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKRSSIAGSSDN 1033

Human   710 SPSFVSMEDVRI-----------------------HEPLPPPPPQR-RDTH------PSVVETDG 744
            |.::|.:.|..|                       |....|...:| ||..      .|.:|.|.
  Fly  1034 SDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDS 1098

Human   745 -HARVVVPTLKQHSHPPPLALGS-------GLHAPHKGPLPQASDPAVARQHRPLPS-----TPD 796
             |....:..|....|...|...|       |:.:.|:.....::......:|..:..     ..|
  Fly  1099 DHYYETLSPLGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETD 1163

Human   797 SSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSR-- 859
            |..|....|..|.........|:....||                        :||  ||:::  
  Fly  1164 SDDHGDGEPDLRQRNYNDSGVDMRNHRLP------------------------KPP--PPQNQVY 1202

Human   860 ----------GRSRSTRGG----HMNSGGHAKTRPACQDWT-------------VPLPASAG--- 894
                      ...:|.:|.    :.|:.........|...|             :|.|.:.|   
  Fly  1203 EFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERIPAPETKGPVH 1267

Human   895 RTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCP------------SSPTTPWTPELQG 947
            :...|...|:.....:..||.:..:......:...:.|.|            |.|..|..||:.|
  Fly  1268 QEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHG 1332

Human   948 PTSKDEAGVSEH-----PEAP------------AREPLRRTT----PQQGASGP-----GRSPVG 986
            ....| :|.|:.     ||.|            |:...||||    |......|     .:||: 
  Fly  1333 SGELD-SGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPL- 1395

Human   987 QARQPEKPSHLHLEKASSW--------PHRRDSGRPPGDSSGQAVAPSEGANKHKG----WSRQG 1039
               .||:  .|..|:.:||        .....:..|.||   :.|.|:...  |.|    ::..|
  Fly  1396 ---DPER--ELDAEQTTSWYAECGVFKQATNGAVSPRGD---EPVTPTPSG--HGGVSSWYAESG 1450

Human  1040 LRRPS-ILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMGGFSRRCSKLINSSQLLYQEYSDV 1103
            |.:.| |....||.|.|.:.....|..|.:   ..:|..:.            |::.|||.||..
  Fly  1451 LYQTSGISVASSSGSSGVSTGNEAGLGDEL---SSEPHSLF------------SNEPLYQMYSAA 1500

Human  1104 VL---NKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQRLSMAS--SGSLWQEIPVVRNST 1163
            .|   .:::::....:...|. |..:..:|...:....:.||.:...:  |.:||.|||.|.:|.
  Fly  1501 KLESITRDLEAHGSSDGYEEI-GLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSC 1564

Human  1164 VLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQ-----LSTSLRATLSNQEHQWLFSRLQ 1223
            :|.::|..::.|||.|||:|.||||||:|||:...||.     |.:|:   ||.::.:.|||.:.
  Fly  1565 ILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSV---LSAKDRKALFSYIV 1626

Human  1224 DVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSN- 1287
            .|.:.|...|::||..:::||....:...:...|.....||:.:..:|...:||.:.|..|..: 
  Fly  1627 PVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESL 1691

Human  1288 -FREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHAL-EQ 1350
             |::.||:||:.|.|..|:|.|||:||.||||||.||:..:..:..|.:.||.|:.|...|| ::
  Fly  1692 AFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQK 1756

Human  1351 LIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLI----------SQSRWLVKSGELTALEF--- 1402
            ::..||.......:..||..:::::||...:..|.          ::.|:|||.||||.|.:   
  Fly  1757 VVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGE 1821

Human  1403 SASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSI---RGEKC------EMKLH 1458
            .|.....::|....::..||:|.|||.:.|..|.|.|||:.|.|.:   .|:..      ::| .
  Fly  1822 DAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLK-D 1885

Human  1459 GPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREEL---DLLECYNSPQVQCLRA 1520
            ...|||..:.|.:|......|.:....:.|::.||:.|:..|..|.   .|.|.::.|||....:
  Fly  1886 QAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHS 1950

Human  1521 YKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRV 1585
            |:..|.|.|.||..|||.|:::..|||.:|.|:.||..||||....|.:::..|||:|||:.||:
  Fly  1951 YESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRL 2015

Human  1586 KTAKLQLVEQQ 1596
            .|.....:|.|
  Fly  2016 LTFTATYLESQ 2026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARHGEF5NP_005426.2 ARHGEF5_35 1..478 CDD:292081 115/559 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..246 26/121 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 258..455 54/258 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..1072 154/848 (18%)
RhoGEF 1178..1356 CDD:279015 66/185 (36%)
PH_ephexin 1378..1504 CDD:269929 39/147 (27%)
PH 1391..1497 CDD:278594 35/117 (30%)
SH3_ARHGEF5_19 1514..1568 CDD:212873 23/53 (43%)
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 66/184 (36%)
PH_ephexin 1805..1931 CDD:269929 38/126 (30%)
SH3_ephexin1_like 1944..1998 CDD:212727 23/53 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 117 1.000 Domainoid score I5908
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41472
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12845
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.910

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